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公开(公告)号:US09522188B2
公开(公告)日:2016-12-20
申请号:US11639408
申请日:2006-12-13
申请人: Andrew Finn , Niraj Vasisht
发明人: Andrew Finn , Niraj Vasisht
IPC分类号: A61K31/485 , A61K45/06 , A61K9/00 , A61K9/70 , A61K31/4468
CPC分类号: A61K31/485 , A61K9/0014 , A61K9/006 , A61K9/7007 , A61K9/7038 , A61K9/7092 , A61K31/4468 , A61K45/06 , A61K2300/00
摘要: The present invention relates to a solid pharmaceutical dosage form for abusable drug delivery with reduced illicit abuse potential. The dosage form is presented as a bioerodable transmucosal delivery device that includes an abusable drug and an antagonist to the abusable drug associated with an abuse-resistant matrix. The devices of the invention may be in the form of a layered film or a tablet. Upon application in a non-abusive manner, the device adheres to the mucosal surface, providing transmucosal drug delivery of the drug with minimal absorption of the antagonist into systemic circulation.
摘要翻译: 本发明涉及具有减少的非法滥用潜力的可滥用药物递送的固体药物剂型。 该剂型表示为生物侵蚀性经粘膜递送装置,其包括与耐滥用基质相关的可滥用药物的可滥用药物和拮抗剂。 本发明的装置可以是分层膜或片剂的形式。 当以非侮辱性方式施用时,该装置粘附于粘膜表面,以最小程度的吸收拮抗剂进入全身循环,提供药物的经粘膜药物递送。
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公开(公告)号:US20120164191A1
公开(公告)日:2012-06-28
申请号:US13413112
申请日:2012-03-06
申请人: Andrew Finn , Niraj Vasisht
发明人: Andrew Finn , Niraj Vasisht
IPC分类号: A61K9/00 , A61P25/04 , A61K31/485
CPC分类号: A61K31/485 , A61K9/0056 , A61K9/006 , A61K9/7007 , A61K31/4468
摘要: The present invention provides methods for enhancing transmucosal uptake of a medicament, e.g., fentanyl or buprenorphine, to a subject and related devices. The method includes administering to a subject a transmucosal drug delivery device comprising the medicament. Also provided are devices suitable for transmucosal administration of a medicament to a subject and methods of their administration and use. The devices include a medicament disposed in a mucoadhesive polymeric diffusion environment and a barrier environment.
摘要翻译: 本发明提供了用于增强药物(例如芬太尼或丁丙诺啡)对受试者和相关装置的经粘膜摄取的方法。 该方法包括对受试者施用包含药物的经粘膜药物递送装置。 还提供了适用于药物对受试者的经粘膜给药的装置及其施用和使用方法。 这些装置包括设置在粘膜粘附聚合物扩散环境和屏障环境中的药物。
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公开(公告)号:US20110262522A1
公开(公告)日:2011-10-27
申请号:US13184306
申请日:2011-07-15
申请人: Andrew Finn , Niraj Vasisht
发明人: Andrew Finn , Niraj Vasisht
IPC分类号: A61K9/70 , A61P25/04 , A61P25/30 , A61K31/485
CPC分类号: A61K31/485 , A61K9/0056 , A61K9/006 , A61K9/7007 , A61K31/4468
摘要: The present invention provides methods for enhancing transmucosal uptake of a medicament, e.g., fentanyl or buprenorphine, to a subject and related devices. The method includes administering to a subject a transmucosal drug delivery device comprising the medicament. Also provided are devices suitable for transmucosal administration of a medicament to a subject and methods of their administration and use. The devices include a medicament disposed in a mucoadhesive polymeric diffusion environment and a barrier environment.
摘要翻译: 本发明提供了用于增强药物(例如芬太尼或丁丙诺啡)对受试者和相关装置的经粘膜摄取的方法。 该方法包括对受试者施用包含药物的经粘膜药物递送装置。 还提供了适用于药物对受试者的经粘膜给药的装置及其施用和使用方法。 这些装置包括设置在粘膜粘附聚合物扩散环境和屏障环境中的药物。
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公开(公告)号:US20090074941A1
公开(公告)日:2009-03-19
申请号:US12207481
申请日:2008-09-09
申请人: Andrew Finn , Alan Gabelman
发明人: Andrew Finn , Alan Gabelman
IPC分类号: C11B9/02
摘要: A method of dewaxing a citrus oil by subjecting the oil to a filtration process, in which the oil is caused to flow parallel to a porous membrane during which process it is maintained at a temperature of less than about 11° C., said membrane having an average pore size of from about 0.05-5 micrometres. The method produces citrus oils that are dewaxed to an unusually high extent.
摘要翻译: 一种通过对油进行过滤处理来使柑橘油脱蜡的方法,其中使油平行于多孔膜流动,在该过程中,将其保持在小于约11℃的温度,所述膜具有 平均孔径为约0.05-5微米。 该方法生产的柑橘油脱蜡至非常高的程度。
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公开(公告)号:USD650034S1
公开(公告)日:2011-12-06
申请号:US29290772
申请日:2008-01-11
申请人: Timothy Lindsay , Andrew Finn , Charles Kushell , David Kucy , Quan Le , Jeremy Wilkens , Francisco Hernandez
设计人: Timothy Lindsay , Andrew Finn , Charles Kushell , David Kucy , Quan Le , Jeremy Wilkens , Francisco Hernandez
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公开(公告)号:US20100015183A1
公开(公告)日:2010-01-21
申请号:US11817915
申请日:2007-07-23
申请人: Andrew Finn , Niraj Vasisht
发明人: Andrew Finn , Niraj Vasisht
IPC分类号: A61K31/4468 , A61P25/00 , A61K9/00 , A61K31/485
CPC分类号: A61K31/485 , A61K9/0056 , A61K9/006 , A61K9/7007 , A61K31/4468
摘要: The present invention provides methods for enhancing transmucosal uptake of a medicament, e.g., fentanyl or buprenorphine, to a subject and related devices. The method includes administering to a subject a transmucosal drug delivery device comprising the medicament. Also provided are devices suitable for transmucosal administration of a medicament to a subject and methods of their administration and use. The devices include a medicament disposed in a mucoadhesive polymeric diffusion environment and a barrier environment.
摘要翻译: 本发明提供了用于增强药物(例如芬太尼或丁丙诺啡)对受试者和相关装置的经粘膜摄取的方法。 该方法包括对受试者施用包含药物的经粘膜药物递送装置。 还提供了适用于药物对受试者的经粘膜给药的装置及其施用和使用方法。 这些装置包括设置在粘膜粘附聚合物扩散环境和屏障环境中的药物。
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7.
公开(公告)号:US20170035688A9
公开(公告)日:2017-02-09
申请号:US13724959
申请日:2012-12-21
申请人: Andrew Finn , Niraj Vasisht
发明人: Andrew Finn , Niraj Vasisht
IPC分类号: A61K9/00
CPC分类号: A61K9/00 , A61K9/006 , A61K31/485
摘要: Provided herein are methods for treating chronic pain by administering low doses of buprenorphine twice daily (or once daily) via a transmucosal drug delivery device. The methods and devices efficiently treat chronic pain without significant side effects.
摘要翻译: 本文提供了通过经由经粘膜药物递送装置每天两次(或每天一次)施用低剂量丁丙诺啡来治疗慢性疼痛的方法。 方法和装置有效地治疗慢性疼痛,没有显着的副作用。
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公开(公告)号:US09422506B2
公开(公告)日:2016-08-23
申请号:US12207481
申请日:2008-09-09
申请人: Andrew Finn , Alan Gabelman
发明人: Andrew Finn , Alan Gabelman
摘要: A method of dewaxing a citrus oil by subjecting the oil to a filtration process, in which the oil is caused to flow parallel to a porous membrane during which process it is maintained at a temperature of less than about 11° C., said membrane having an average pore size of from about 0.05-5 micrometers. The method produces citrus oils that are dewaxed to an unusually high extent.
摘要翻译: 一种通过对油进行过滤处理来使柑橘油脱蜡的方法,其中使油平行于多孔膜流动,在该过程中,将其保持在小于约11℃的温度,所述膜具有 平均孔径为约0.05-5微米。 该方法生产的柑橘油脱蜡至非常高的程度。
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9.
公开(公告)号:US20140178440A1
公开(公告)日:2014-06-26
申请号:US13724959
申请日:2012-12-21
申请人: Andrew Finn , Niraj Vasisht
发明人: Andrew Finn , Niraj Vasisht
IPC分类号: A61K9/00
CPC分类号: A61K9/00 , A61K9/006 , A61K31/485
摘要: Provided herein are methods for treating chronic pain by administering low doses of buprenorphine twice daily (or once daily) via a transmucosal drug delivery device. The methods and devices efficiently treat chronic pain without significant side effects.
摘要翻译: 本文提供了通过经由经粘膜药物递送装置每天两次(或每天一次)施用低剂量丁丙诺啡来治疗慢性疼痛的方法。 方法和装置有效地治疗慢性疼痛,没有显着的副作用。
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公开(公告)号:US08147866B2
公开(公告)日:2012-04-03
申请号:US13184306
申请日:2011-07-15
申请人: Andrew Finn , Niraj Vasisht
发明人: Andrew Finn , Niraj Vasisht
CPC分类号: A61K31/485 , A61K9/0056 , A61K9/006 , A61K9/7007 , A61K31/4468
摘要: The present invention provides methods for enhancing transmucosal uptake of a medicament, e.g., fentanyl or buprenorphine, to a subject and related devices. The method includes administering to a subject a transmucosal drug delivery device comprising the medicament. Also provided are devices suitable for transmucosal administration of a medicament to a subject and methods of their administration and use. The devices include a medicament disposed in a mucoadhesive polymeric diffusion environment and a barrier environment.
摘要翻译: 本发明提供了用于增强药物(例如芬太尼或丁丙诺啡)对受试者和相关装置的经粘膜摄取的方法。 该方法包括对受试者施用包含药物的经粘膜药物递送装置。 还提供了适用于药物对受试者的经粘膜给药的装置及其施用和使用方法。 这些装置包括设置在粘膜粘附聚合物扩散环境和屏障环境中的药物。
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