公开(公告)号：US07122019B1

公开(公告)日：2006-10-17

申请号：US09724691

申请日：2000-11-28

申请人： Randy J. Kesten ,  Michael H. Rosenthal ,  Sam G. Payne ,  Andrew K. Kramer ,  Sophia Pesotchinsky

发明人： Randy J. Kesten ,  Michael H. Rosenthal ,  Sam G. Payne ,  Andrew K. Kramer ,  Sophia Pesotchinsky

IPC分类号： A61M31/00 ,  A61M29/00 ,  A61M37/00 ,  A61N1/362

CPC分类号： A61M25/10 ,  A61M2025/0037

摘要： A catheter for delivering a therapeutic or diagnostic agent to a branch blood vessel of a major blood vessel, generally comprising an elongated shaft having at least one lumen in fluid communication with an agent delivery port in a distal section of the shaft, an expandable tubular member on the distal section of the shaft, and a radially expandable member on the tubular member. The tubular member is configured to extend within the blood vessel up-stream and down-stream of a branch vessel, and has an interior passageway which is radially expandable within the blood vessel to separate blood flow through the blood vessel into an outer blood flow stream exterior to the tubular member and an inner blood flow stream within the interior passageway of the tubular member. The radially expandable member is located down-stream of the shaft agent delivery port, and has an expanded configuration with an outer diameter larger than an outer diameter of the tubular member. The expanded radially expandable member is configured to decrease the blood flow in the outer blood flow stream down-stream of the branch vessel. The catheter provides for delivery of an agent to a branch vessel of a major vessel, and continuous perfusion of the major blood vessel. Another aspect of the invention is directed to methods of delivering a therapeutic or diagnostic agent to one or both kidney's of a patient.

摘要翻译： 一种用于将治疗剂或诊断剂递送到主要血管的分支血管的导管，通常包括细长轴，所述细长轴具有与所述轴的远端部分中的药剂输送端口流体连通的至少一个内腔， 在所述轴的远侧部分上，以及在所述管状构件上的径向可扩张构件。 管状构件构造成在分支容器的上游和下游的血管内延伸，并且具有在血管内可径向扩张的内部通道，以将通过血管的血液分离成外部血流 管状构件的外部和管状构件的内部通道内的内部血流。 径向可膨胀构件位于轴剂输送口的下游，并且具有外径大于管状构件的外径的膨胀构型。 扩张的可径向扩张的构件被配置为减小分支容器下游的外部血液流中的血流。 导管提供将药剂递送到主血管的分支血管，并连续灌注主血管。 本发明的另一方面涉及将治疗剂或诊断剂递送到患者的一种或两种肾脏的方法。

公开(公告)号：US08012121B2

公开(公告)日：2011-09-06

申请号：US11768390

申请日：2007-06-26

申请人： Harry B. Goodson, IV ,  Jeffrey M. Elkins ,  Samir R. Patel ,  Aurelio Valencia ,  Ricardo Aboytes ,  Craig A. Ball ,  Randy J. Kesten ,  Andrew K. Kramer ,  Sam G. Payne ,  Sophia Pesotchinsky ,  Michael H. Rosenthal

发明人： Harry B. Goodson, IV ,  Jeffrey M. Elkins ,  Samir R. Patel ,  Aurelio Valencia ,  Ricardo Aboytes ,  Craig A. Ball ,  Randy J. Kesten ,  Andrew K. Kramer ,  Sam G. Payne ,  Sophia Pesotchinsky ,  Michael H. Rosenthal

IPC分类号： A61M31/00 ,  A61F2/06

CPC分类号： A61M25/04 ,  A61M25/0029 ,  A61M25/0054 ,  A61M25/0147 ,  A61M25/0152 ,  A61M29/02 ,  A61M39/06 ,  A61M2025/0008 ,  A61M2025/0034 ,  A61M2025/0037 ,  A61M2025/0161 ,  A61M2025/0188 ,  A61M2025/1004 ,  A61M2025/1047 ,  A61M2025/1052

摘要： Two renal delivery members have two distal ports that are adapted to be positioned within two renal arteries via their corresponding renal ostia at unique locations along an abdominal aortic wall. A proximal coupler assembly is outside the body and is coupled to deliver material to the two distal ports for bi-lateral renal therapy. One or both of the delivery members may be self-cannulating into the corresponding renal ostium, or may be controllably steered into the respective ostium. Non-occlusive anchors may be coupled with one or both of the delivery members at anchoring positions in the renal artery or abdominal aorta to secure the renal delivery member within the renal artery. Renal-active fluid agents are coupled to the bi-lateral delivery system. Another renal therapy system cannulates a renal vein from the vena cava and controls a retrograde delivery of agents to the respective kidney.

公开(公告)号：US07481803B2

公开(公告)日：2009-01-27

申请号：US10422624

申请日：2003-04-23

申请人： Randy J. Kesten ,  Michael H. Rosenthal ,  Sam G. Payne ,  Andrew K. Kramer ,  Sophia Pesotchinsky

发明人： Randy J. Kesten ,  Michael H. Rosenthal ,  Sam G. Payne ,  Andrew K. Kramer ,  Sophia Pesotchinsky

IPC分类号： A61M31/00

CPC分类号： A61M25/10 ,  A61K31/55 ,  A61M25/005 ,  A61M25/1002 ,  A61M25/1011 ,  A61M29/02 ,  A61M2025/0034 ,  A61M2025/0035 ,  A61M2025/0036 ,  A61M2025/0037 ,  A61M2025/0039 ,  A61M2025/004 ,  A61M2025/105 ,  A61M2025/1052 ,  A61M2025/1072 ,  A61M2025/1095 ,  A61M2025/1097

摘要： A catheter for delivering a therapeutic or diagnostic agent to a branch blood vessel of a major blood vessel, generally comprising an elongated shaft having at least one lumen in fluid communication with an agent delivery port in a distal section of the shaft, an expandable tubular member on the distal section of the shaft, and a radially expandable member on the tubular member. The tubular member is configured to extend within the blood vessel up-stream and down-stream of a branch vessel, and has an interior passageway which is radially expandable within the blood vessel to separate blood flow through the blood vessel into an outer blood flow stream exterior to the tubular member and an inner blood flow stream within the interior passageway of the tubular member.

摘要翻译： 一种用于将治疗剂或诊断剂递送到主要血管的分支血管的导管，通常包括细长轴，所述细长轴具有与所述轴的远端部分中的药剂输送端口流体连通的至少一个内腔， 在所述轴的远侧部分上，以及在所述管状构件上的径向可扩张构件。 管状构件构造成在分支容器的上游和下游的血管内延伸，并且具有在血管内可径向扩张的内部通道，以将通过血管的血液分离成外部血流 管状构件的外部和管状构件的内部通道内的内部血流。