公开(公告)号：US10307493B2

公开(公告)日：2019-06-04

申请号：US14777168

申请日：2014-03-14

申请人： Biocompatibles UK Limited ,  Matthew R. Dreher ,  Bradford J. Wood ,  Ayele H. Negussie ,  Andrew Leonard Lewis ,  Yiqing Tang

发明人： Matthew R. Dreher ,  Bradford J. Wood ,  Ayele H. Negussie ,  Andrew Leonard Lewis ,  Yiqing Tang

IPC分类号： A61K9/00 ,  A61K49/04 ,  C08F116/06 ,  C08L29/04 ,  B82Y5/00

摘要： This invention concerns imageable, radiopaque embolic beads, which are particularly useful for monitoring embolization procedures. The beads comprise iodine containing compounds which are covalently incorporated into the polymer network of a preformed hydrogel bead. The beads are prepared by activating pre-formed hydrogel beads towards nucleophilic attack and then covalently attaching iodinated compounds into the polymer network. The radiopaque beads may be loaded with chemotherapeutic agents and used in methods of embolizing hyperplastic tissue or solid tumors.

公开(公告)号：US09765213B2

公开(公告)日：2017-09-19

申请号：US13355910

申请日：2012-01-23

申请人： Andrew Leonard Lewis ,  Steven Peter Armes ,  Andrew W. Lloyd ,  Jonathan P. Salvage

发明人： Andrew Leonard Lewis ,  Steven Peter Armes ,  Andrew W. Lloyd ,  Jonathan P. Salvage

IPC分类号： A61K47/30 ,  A61P35/00 ,  C08L53/00 ,  A61K9/107 ,  C08F293/00

CPC分类号： C08L53/00 ,  A61K9/1075 ,  C08F293/005 ,  C08L2666/02

摘要： An aqueous composition comprises an amphiphilic block copolymer, having a hydrophilic block comprising pendant zwitterionic groups and a hydrophobic block, and a biologically active compound associated with the polymer. The polymer is preferably in the form of micelles, and preferably the biological active is a hydrophobic drug. The hydrophilic block is preferably formed from acrylic monomer including phosphorylcholine groups. The hydrophobic group is suitably formed from monomer which has groups which can be ionised at useful pH's, especially tertiary amine groups. Micelles may be formed by dissolving the block copolymer in aqueous solvent at a pH at which the amine groups are protonated then raising the pH to a value at which the amine groups are substantially deprotonated, whereupon micelles spontaneously form. The preformed micelles are then contacted with active, under conditions such that solubilisation of the active occurs. The active may be for tumour treatment.

公开(公告)号：US20160030602A1

公开(公告)日：2016-02-04

申请号：US14777168

申请日：2014-03-14

申请人： Matthew R. DREHER ,  Bradford J. WOOD ,  Ayele H. NEGUSSIE ,  Andrew Leonard LEWIS ,  Yiqing TANG ,  Biocompatibles UK Limited

发明人： Matthew J. DREHER ,  Bradford J. WOOD ,  Ayele H. NEGUSSIE ,  Andrew Leonard LEWIS ,  Yiqing TANG

IPC分类号： A61K49/04 ,  C08L29/04 ,  C08F116/06

CPC分类号： A61K49/0442 ,  A61K49/0438 ,  A61K49/0476 ,  A61K49/0485 ,  B82Y5/00 ,  C08F116/06 ,  C08L29/04

摘要： This invention concerns imageable, radiopaque embolic beads, which are particularly useful for monitoring embolization procedures. The beads comprise iodine containing compounds which are covalently incorporated into the polymer network of a preformed hydrogel bead. The beads are prepared by activating pre-formed hydrogel beads towards nucleophilic attack and then covalently attaching iodinated compounds into the polymer network. The radiopaque beads may be loaded with chemotherapeutic agents and used in methods of embolizing hyperplastic tissue or solid tumors.

摘要翻译： 本发明涉及可成像的不透射线的栓塞珠，其特别适用于监测栓塞过程。 珠粒包含共价掺入到预先形成的水凝胶珠的聚合物网络中的含碘化合物。 通过将预形成的水凝胶珠活化以进行亲核攻击然后将碘化化合物共价连接到聚合物网络中来制备珠粒。 不透射线珠可以装载化学治疗剂并用于栓塞增生组织或实体瘤的方法。