公开(公告)号：US07112324B1

公开(公告)日：2006-09-26

申请号：US09673735

申请日：1999-04-21

申请人： Bernd Dorken ,  Gert Riethmuller ,  Peter Kufer ,  Ralf Lutterbuse ,  Ralf Bargou ,  Anja Loffler

发明人： Bernd Dorken ,  Gert Riethmuller ,  Peter Kufer ,  Ralf Lutterbuse ,  Ralf Bargou ,  Anja Loffler

IPC分类号： C07K16/00

CPC分类号： C07K16/2809 ,  A61K38/00 ,  A61K48/00 ,  A61K2039/505 ,  C07K16/2803 ,  C07K2317/31 ,  C07K2317/34 ,  C07K2319/00

摘要： Described are novel single-chain multifunctional polypeptides comprising at least two binding sites specific for the CD19 and CD3 antigen, respectively. Further provided are polypeptides, wherein the above-described polypeptide comprises at least one further domain, preferably of pre-determined function. Furthermore, polynucleotides encoding said polypeptides as well as to vectors comprising said polynucleotides and host cells transformed therewith and their use in the production of said polypeptides are described, In addition, compositions, preferably pharmaceutical and diagnostic compositions are provided comprising any of the afore-described polypeptides, polynucleotides or vectors. Described is also the use of the afore-mentioned polypeptides, polynucleotides and vectors for the preparation of pharmaceutical compositions for immunotherapy, preferably against B-cell malignancies such as non-Hodgkin lymphoma.

摘要翻译： 描述了分别包含至少两个特异于CD19和CD3抗原的结合位点的新型单链多功能多肽。 还提供多肽，其中上述多肽包含至少一个其它结构域，优选预定义的功能。 此外，还描述了编码所述多肽的多核苷酸以及包含所述多核苷酸和由其转化的宿主细胞的载体及其在产生所述多肽中的用途。此外，提供组合物，优选药物和诊断组合物，包括任何上述 多肽，多核苷酸或载体。 还描述了上述多肽，多核苷酸和载体用于制备用于免疫治疗的药物组合物，优选抗B细胞恶性肿瘤例如非霍奇金淋巴瘤的用途。

公开(公告)号：US07575923B2

公开(公告)日：2009-08-18

申请号：US11418058

申请日：2006-05-05

申请人： Bernd Dorken ,  Gert Riethmuller ,  Peter Kufer ,  Ralf Lutterbuse ,  Ralf Bargou ,  Anja Loffler

发明人： Bernd Dorken ,  Gert Riethmuller ,  Peter Kufer ,  Ralf Lutterbuse ,  Ralf Bargou ,  Anja Loffler

IPC分类号： C12N5/10 ,  C07H21/02 ,  C07H21/04 ,  C12P21/08 ,  A61K39/395

CPC分类号： C07K16/2809 ,  A61K38/00 ,  A61K48/00 ,  A61K2039/505 ,  C07K16/2803 ,  C07K2317/31 ,  C07K2317/34 ,  C07K2319/00

摘要： Described are novel single-chain multifunctional polypeptides comprising at least two binding sites specific for the CD19 and CD3 antigen, respectively. Further provided are polypeptides, wherein the above-described polypeptide comprises at least one further domain, preferably of pre-determined function. Furthermore, polynucleotides encoding said polypeptides as well as to vectors comprising said polynucleotides and host cells transformed therewith and their use in the production of said polypeptides are described. In addition, compositions, preferably pharmaceutical and diagnostic compositions are provided comprising any of the afore-described polypeptides, polynucleotides or vectors. Described is also the use of the afore-mentioned polypeptides, polynucleotides and vectors for the preparation of pharmaceutical compositions for immunotherapy, preferably against B-cell malignancies such as non-Hodgkin lymphoma.

摘要翻译： 描述了分别包含至少两个特异于CD19和CD3抗原的结合位点的新型单链多功能多肽。 还提供多肽，其中上述多肽包含至少一个其它结构域，优选预定义的功能。 此外，描述了编码所述多肽的多核苷酸以及包含所述多核苷酸和由其转化的宿主细胞的载体及其在所述多肽的制备中的用途。 此外，提供组合物，优选药物和诊断组合物，其包含任何上述多肽，多核苷酸或载体。 还描述了上述多肽，多核苷酸和载体用于制备用于免疫治疗的药物组合物，优选抗B细胞恶性肿瘤例如非霍奇金淋巴瘤的用途。

公开(公告)号：US20060193852A1

公开(公告)日：2006-08-31

申请号：US11418058

申请日：2006-05-05

申请人： Bernd Dorken ,  Gert Riethmuller ,  Peter Kufer ,  Ralf Lutterbuse ,  Ralf Bargou ,  Anja Loffler

发明人： Bernd Dorken ,  Gert Riethmuller ,  Peter Kufer ,  Ralf Lutterbuse ,  Ralf Bargou ,  Anja Loffler

IPC分类号： A61K39/395 ,  C07K16/28

CPC分类号： C07K16/2809 ,  A61K38/00 ,  A61K48/00 ,  A61K2039/505 ,  C07K16/2803 ,  C07K2317/31 ,  C07K2317/34 ,  C07K2319/00

摘要： Described are novel single-chain multifunctional polypeptides comprising at least two binding sites specific for the CD19 and CD3 antigen, respectively. Further provided are polypeptides, wherein the above-described polypeptide comprises at least one further domain, preferably of pre-determined function. Furthermore, polynucleotides encoding said polypeptides as well as to vectors comprising said polynucleotides and host cells transformed therewith and their use in the production of said polypeptides are described. In addition, compositions, preferably pharmaceutical and diagnostic compositions are provided comprising any of the afore-described polypeptides, polynucleotides or vectors. Described is also the use of the afore-mentioned polypeptides, polynucleotides and vectors for the preparation of pharmaceutical compositions for immunotherapy, preferably against B-cell malignancies such as non-Hodgkin lymphoma.

摘要翻译： 描述了分别包含至少两个特异于CD19和CD3抗原的结合位点的新型单链多功能多肽。 还提供多肽，其中上述多肽包含至少一个其它结构域，优选预定义的功能。 此外，描述了编码所述多肽的多核苷酸以及包含所述多核苷酸和由其转化的宿主细胞的载体及其在所述多肽的制备中的用途。 此外，提供组合物，优选药物和诊断组合物，其包含任何上述多肽，多核苷酸或载体。 还描述了上述多肽，多核苷酸和载体用于制备用于免疫治疗的药物组合物，优选抗B细胞恶性肿瘤例如非霍奇金淋巴瘤的用途。