公开(公告)号：US20110189680A1

公开(公告)日：2011-08-04

申请号：US12991922

申请日：2009-05-29

申请人： Paul Keown ,  Andreas Scherer ,  Oliver Gunther ,  Robert Balshaw ,  Raymond Ng ,  Alice Mui ,  Robert McMaster ,  Bruce McManus ,  Gabriela Cohen Freue ,  Anna Meredith

发明人： Paul Keown ,  Andreas Scherer ,  Oliver Gunther ,  Robert Balshaw ,  Raymond Ng ,  Alice Mui ,  Robert McMaster ,  Bruce McManus ,  Gabriela Cohen Freue ,  Anna Meredith

IPC分类号： C12Q1/68 ,  G01N33/53 ,  G01N33/68 ,  C12Q1/48 ,  C12Q1/00 ,  C12Q1/37 ,  G01N33/573 ,  H01J49/26

CPC分类号： G01N33/6842 ,  C12Q1/6883 ,  C12Q2600/112 ,  C12Q2600/158 ,  C12Q2600/178 ,  G01N2800/245 ,  G01N2800/60 ,  Y10T436/143333

摘要： A method of determining the acute allograft rejection status of a subject, the method comprising the steps of: determining the nucleic acid expression profile of one or more than one nucleic acid markers, or one or more than one proteomic markers in a biological sample from the subject; comparing the expression profile of the one or more than one nucleic acid markers to a control profile; and determining whether the expression level of the one or more than one nucleic acid markers is increased relative to the control profile, wherein the increase of the one or more than one nucleic acid markers is indicative of the acute rejection status of the subject.

摘要翻译： 确定受试者的急性同种异体移植排斥状态的方法，所述方法包括以下步骤：确定来自所述受试者的生物样品中一种或多于一种核酸标记或一种或多于一种蛋白质组标记的核酸表达谱 学科; 将一种或多于一种核酸标记的表达谱与对照图进行比较; 以及确定所述一种或多于一种核酸标志物的表达水平是否相对于所述对照谱增加，其中所述一种或多于一种核酸标志物的增加指示受试者的急性排斥状态。