公开(公告)号：US20070071685A1

公开(公告)日：2007-03-29

申请号：US10584327

申请日：2004-12-21

申请人： Michel Schneider ,  Philippe Bussat ,  Feng Yan ,  Anne Senente

发明人： Michel Schneider ,  Philippe Bussat ,  Feng Yan ,  Anne Senente

IPC分类号： A61K49/22

CPC分类号： A61K47/6925 ,  A61K41/0028 ,  A61K49/225

摘要： Assembly comprising a gas-filled microvesicle and a structural entity which is capable to associate through an electrostatic interaction to the outer surface of said microvesicle (microvesicle associated component—MAC), thereby modifying the physico-chemical properties thereof. Said MAC may optionally comprise a targeting ligand, a bioactive agent, a diagnostic agent or any combination thereof. The assembly of the invention can be formed from gasfilled microbubbles or microballoons and a MAC having a diameter of less than 100 pm, in particular a micelle and is used as an active component in diagnostically and/or therapeutically active formulations, in particular for enhancing the imaging in the field of ultrasound contrast imaging, including targeted ultrasound imaging, ultrasound-mediated drug delivery and other imaging techniques such as molecular resonance imaging (MRI) or nuclear imaging.

摘要翻译： 组件包括充气微泡和结构实体，其能够通过静电相互作用与所述微囊体（微泡相关组分-MAC）的外表面缔合，从而改变其物理化学性质。 所述MAC可以任选地包含靶向配体，生物活性剂，诊断剂或其任何组合。 本发明的组件可以由气体填充的微泡或微球和直径小于100μm的MAC，特别是胶束形成，并且用作诊断和/或治疗活性制剂中的活性成分，特别是用于增强 在超声对比成像领域的成像，包括靶向超声成像，超声介导的药物递送和其他成像技术如分子共振成像（MRI）或核成像。

公开(公告)号：US09750821B2

公开(公告)日：2017-09-05

申请号：US10584327

申请日：2004-12-21

申请人： Michel Schneider ,  Philippe Bussat ,  Feng Yan ,  Anne Senente

发明人： Michel Schneider ,  Philippe Bussat ,  Feng Yan ,  Anne Senente

IPC分类号： A61K47/48 ,  A61K41/00 ,  A61K49/22

CPC分类号： A61K47/6925 ,  A61K41/0028 ,  A61K49/225

摘要： Assembly comprising a gas-filled microvesicle and a structural entity which is capable to associate through an electrostatic interaction to the outer surface of said microvesicle (microvesicle associated component—MAC), thereby modifying the physico-chemical properties thereof. Said MAC may optionally comprise a targeting ligand, a bioactive agent, a diagnostic agent or any combination thereof. The assembly of the invention can be formed from gasfilled microbubbles or microballoons and a MAC having a diameter of less than 100 pm, in particular a micelle and is used as an active component in diagnostically and/or therapeutically active formulations, in particular for enhancing the imaging in the field of ultrasound contrast imaging, including targeted ultrasound imaging, ultrasound-mediated drug delivery and other imaging techniques such as molecular resonance imaging (MRI) or nuclear imaging.

公开(公告)号：US20070081946A1

公开(公告)日：2007-04-12

申请号：US10584382

申请日：2004-12-21

申请人： Michel Schneider ,  Philippe Bussat ,  Feng Yan ,  Anne Senente

发明人： Michel Schneider ,  Philippe Bussat ,  Feng Yan ,  Anne Senente

IPC分类号： A61K49/22

CPC分类号： A61K41/0028 ,  A61K47/6925 ,  A61K49/225

摘要： Assembly comprising a gas-filled microvesicle and a structural entity which is capable to associate through an electrostatic interaction to the outer surface of said microvesicle (microvesicle associated component—MAC), thereby modifying the physico-chemical properties thereof. Said MAC comprises a targeting ligand a diagnostic agent or any combination thereof. Optionally a bioactive agent can further be associated to the MAC. The assembly of the invention can be formed from gas-filled microbubbles or microballoons and a MAC having preferably nanometric dimensions, e.g. a micelle, and is used as an active component in diagnostically and/or therapeutically active formulations, in particular for enhancing the imaging in the field of ultrasound contrast imaging, including targeted ultrasound imaging, ultrasound-mediated drug delivery and and other imaging techniques such as molecular resonance imaging (MRI) or nuclear imaging.

摘要翻译： 组件包括充气微泡和结构实体，其能够通过静电相互作用与所述微囊体（微泡相关组分-MAC）的外表面缔合，从而改变其物理化学性质。 所述MAC包含靶向配体，诊断剂或其任何组合。 可选地，生物活性剂可以进一步与MAC相关联。 本发明的组件可以由气体填充的微泡或微球和具有优选纳米尺度的MAC形成，例如， 胶束，并且用作诊断和/或治疗活性制剂中的活性成分，特别是用于增强超声对比成像领域的成像，包括靶向超声成像，超声介导的药物递送和其它成像技术，例如 分子共振成像（MRI）或核成像。

公开(公告)号：US20110150778A1

公开(公告)日：2011-06-23

申请号：US13018290

申请日：2011-01-31

申请人： Michel Schneider ,  Philippe Bussat ,  Feng Yan ,  Anne Senente

发明人： Michel Schneider ,  Philippe Bussat ,  Feng Yan ,  Anne Senente

IPC分类号： A61B5/055 ,  A61B8/00 ,  A61K39/395 ,  A61K9/00 ,  A61K38/00 ,  A61K38/14 ,  A61K31/70 ,  A61K31/715 ,  A61K31/56 ,  A61K38/22 ,  A61K31/7088 ,  A61P43/00

CPC分类号： A61K41/0028 ,  A61K47/6925 ,  A61K49/225

摘要： Assembly comprising a gas-filled microvesicle and a structural entity which is capable to associate through an electrostatic interaction to the outer surface of said microvesicle (microvesicle associated component—MAC), thereby modifying the physico-chemical properties thereof. Said MAC comprises a targeting ligand a diagnostic agent or any combination thereof. Optionally a bioactive agent can further be associated to the MAC. The assembly of the invention can be formed from gas-filled microbubbles or microballoons and a MAC having preferably nanometric dimensions, e.g. a micelle, and is used as an active component in diagnostically and/or therapeutically active formulations, in particular for enhancing the imaging in the field of ultrasound contrast imaging, including targeted ultrasound imaging, ultrasound-mediated drug delivery and other imaging techniques such as molecular resonance imaging (MRI) or nuclear imaging.

摘要翻译： 组件包括充气微泡和结构实体，其能够通过静电相互作用与所述微囊体（微泡相关组分-MAC）的外表面缔合，从而改变其物理化学性质。 所述MAC包含靶向配体，诊断剂或其任何组合。 可选地，生物活性剂可以进一步与MAC相关联。 本发明的组件可以由气体填充的微泡或微球和具有优选纳米尺度的MAC形成，例如， 胶束，并且用作诊断和/或治疗活性制剂中的活性成分，特别是用于增强超声造影成像领域的成像，包括靶向超声成像，超声介导的药物递送和其他成像技术如分子 共振成像（MRI）或核成像。