公开(公告)号：US06534062B2

公开(公告)日：2003-03-18

申请号：US09820484

申请日：2001-03-28

申请人： Eyal Raz ,  Hearn Jay Cho ,  Douglas Richman ,  Anthony A. Horner

发明人： Eyal Raz ,  Hearn Jay Cho ,  Douglas Richman ,  Anthony A. Horner

IPC分类号： A61K39385

CPC分类号： A61K39/39 ,  A61K39/0011 ,  A61K39/12 ,  A61K39/21 ,  A61K39/385 ,  A61K2039/53 ,  A61K2039/54 ,  A61K2039/543 ,  A61K2039/545 ,  A61K2039/55 ,  A61K2039/55561 ,  A61K2039/57 ,  A61K2039/585 ,  A61K2039/6025 ,  C12N2740/16134 ,  C12Q1/703

摘要： The invention provides methods for T helper-independent activation of an antigen-specific cytotoxic T lymphocyte response in an individual. The methods generally involve administering to an individual an immunostimulatory nucleic acid molecule in an amount effective to increase an antigen-specific CTL response in the individual. The invention further provides methods for increasing chemokine secretion, which can block HIV infection.