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11 条记录 (耗时 0.016 秒)

    Non-sedating acrivastine product
    2.
    发明授权
    Non-sedating acrivastine product 失效
    非镇静阿伐他汀产品

    公开(公告)号：US6077537A

    公开(公告)日：2000-06-20

    申请号：US82803

    申请日：1998-05-21

    申请人： Anthony Booth ,  Harvey Dickstein ,  Jeffrey R. Koup

    发明人： Anthony Booth ,  Harvey Dickstein ,  Jeffrey R. Koup

    IPC分类号： A61K9/20 ,  A61K9/22 ,  A61K9/52 ,  A61K31/4439

    CPC分类号： A61K9/2059 ,  A61K31/4439

    摘要： The present invention relates to methods of using and compositions containing acrivastine which provide antihistaminic therapeutic benefits while minimizing undesirable central nervous system side effects. According to the present invention, the plasma concentration-response curve for acrivastine's sedative side effects is steeper than that of the plasma concentration-response curve for its antihistamine activity. Accordingly, when the peak blood plasma level of acrivastine is maintained within the levels provided by the present invention composition, the central nervous side effects are minimized while the antihistaminic effects are optimized.

    摘要翻译： 本发明涉及使用含阿克斯他汀组合物的方法，其提供抗组胺治疗益处，同时最小化不期望的中枢神经系统副作用。 根据本发明，阿司匹伐他汀镇静剂副作用的血浆浓度 - 反应曲线比抗组织胺活性的血浆浓度 - 反应曲线更为陡峭。 因此，当阿司匹伐他汀的血浆血浆峰值维持在本发明组合物提供的水平之内时，中枢神经副作用最小化，同时优化抗组胺作用。

    Aircraft cargo container
    3.
    发明授权
    Aircraft cargo container 失效
    飞机货物集装箱

    公开(公告)号：US5645184A

    公开(公告)日：1997-07-08

    申请号：US220596

    申请日：1994-03-31

    申请人： David Paul Rowse ,  Debra Anne Sewell ,  Jan Anthony Booth ,  Rob William Ince

    发明人： David Paul Rowse ,  Debra Anne Sewell ,  Jan Anthony Booth ,  Rob William Ince

    IPC分类号： B65D88/12 ,  B65D88/14 ,  B65D88/22 ,  B65D90/32 ,  B65D90/36 ,  F42B39/14 ,  B65D90/02

    CPC分类号： F42B39/14 ,  B65D88/14 ,  B65D90/325

    摘要： An aircraft cargo container (10) is provided with one or more expandable regions for expansion under blast loading thereby to absorb a portion of the blast energy from a blast within the container (10). The absorbing means may comprise corrugated or concertina shaped sheets (20, 22, 34) which expand under blast loading and together with a blast absorbing material (24). The sheets (20, 22, 34) and material (24) may be provided in one or more panels (12, 14) and/or at one or more edged if required.

    摘要翻译： 飞机货物集装箱（10）设置有一个或多个可膨胀区域，用于在鼓风装载下膨胀，从而从容器（10）内的鼓风中吸收一部分爆炸能量。 吸收装置可以包括在鼓风装载下膨胀并与鼓风吸收材料（24）一起膨胀的波纹或三角形片状片材（20,22,34）。 如果需要，片材（20,22,34）和材料（24）可以设置在一个或多个面板（12,14）中和/或一个或多个边缘。

    (−)-Pseudoephedrine as a sympathomimetic drug
    6.
    发明授权
    (−)-Pseudoephedrine as a sympathomimetic drug 有权
    （ - ） - 伪麻黄素作为拟交感神经药物

    公开(公告)号：US06495529B1

    公开(公告)日：2002-12-17

    申请号：US09743052

    申请日：2001-04-16

    申请人： Anthony Booth ,  William T. Sherman ,  Peter Raven ,  James L. Caffrey ,  Thomas Yorio ,  Michael Forster ,  Patricia Gwirtz

    发明人： Anthony Booth ,  William T. Sherman ,  Peter Raven ,  James L. Caffrey ,  Thomas Yorio ,  Michael Forster ,  Patricia Gwirtz

    IPC分类号： A61K31135

    CPC分类号： A61K31/137 ,  Y10S514/912

    摘要： The present invention provides pharmaceutical compositions which include (−)-pseudoephedrine and a pharmaceutically acceptable carrier, wherein the (−)-pseudoephedrine is substantially-free of (+)-pseudoephedrine. In another embodiment, the present invention provides methods of relieving nasal and bronchial congestion and of inducing pupil dilation which include administering a pharmaceutically effective amount of (−)-pseudoephedrine to a mammal. The (−)-pseudoephedrine used in the present methods is substantially free of (+)-pseudoephedrine and also substantially free of side effects caused by administration of (+)-pseudoephedrine.

    摘要翻译： 本发明提供包含（ - ） - 伪麻黄碱和药学上可接受的载体的药物组合物，其中（ - ） - 伪麻黄碱基本上不含（+） - 伪麻黄碱。 在另一个实施方案中，本发明提供减轻鼻和支气管充血并诱导瞳孔扩张的方法，其包括向哺乳动物施用药学有效量的（ - ） - 伪麻黄碱。 本方法中使用的（ - ） - 伪麻黄素基本上不含（+） - 伪麻黄碱，并且基本上没有由（+） - 伪麻黄碱施用引起的副作用。

    (-)-Pseudoephedrine as a sympathomimetic drug
    9.
    发明申请
    (-)-Pseudoephedrine as a sympathomimetic drug 审中-公开
    （ - ） - 伪麻黄素作为拟交感神经药物

    公开(公告)号：US20080242733A1

    公开(公告)日：2008-10-02

    申请号：US11485928

    申请日：2006-07-13

    申请人： Anthony Booth ,  William T. Sherman ,  Peter Raven ,  James L. Caffrey ,  Thomas Yorio ,  Michael Forster ,  Patricia Gwirtz

    发明人： Anthony Booth ,  William T. Sherman ,  Peter Raven ,  James L. Caffrey ,  Thomas Yorio ,  Michael Forster ,  Patricia Gwirtz

    IPC分类号： A61K31/137 ,  A61P11/00

    CPC分类号： A61K31/137

    摘要： The present invention provides pharmaceutical compositions which include (−)-pseudoephedrine and a pharmaceutically acceptable carrier, wherein the (−)-pseudoephedrine is substantially-free of (+)-pseudoephedrine. In another embodiment, the present invention provides methods of relieving nasal and bronchial congestion and of inducing pupil dilation which include administering a pharmaceutically effective amount of (−)-pseudoephedrine to a mammal. The (−)-pseudoephedrine used in the present methods is substantially free of (+)-pseudoephedrine and also substantially free of side effects caused by administration of (+)-pseudoephedrine.

    摘要翻译： 本发明提供包含（ - ） - 伪麻黄碱和药学上可接受的载体的药物组合物，其中（ - ） - 伪麻黄碱基本上不含（+） - 伪麻黄碱。 在另一个实施方案中，本发明提供减轻鼻和支气管充血并诱导瞳孔扩张的方法，其包括向哺乳动物施用药学有效量的（ - ） - 伪麻黄碱。 本方法中使用的（ - ） - 伪麻黄素基本上不含（+） - 伪麻黄碱，并且基本上没有由（+） - 伪麻黄碱施用引起的副作用。

    Stereoisomers with high affinity for adrenergic receptors
    10.
    发明授权
    Stereoisomers with high affinity for adrenergic receptors 有权

    公开(公告)号：US07232837B2

    公开(公告)日：2007-06-19

    申请号：US10681915

    申请日：2003-10-09

    申请人： Anthony Booth ,  James L. Caffrey

    发明人： Anthony Booth ,  James L. Caffrey

    IPC分类号： A61K31/44 ,  C07D211/04

    CPC分类号： C07C215/60 ,  C07C215/30

    摘要： The present invention provides stereoscopically-pure diastereomers of Formula I: In a preferred embodiment, the stereoisomers of the present invention are of Formula II, depicted below: R2, R3 and R4 are independently H, OH, OCH3, CH2OH, NHCONH2, NH2, halogen or CF3, and R1 is pyridine, or an amine which may be substituted with hydrogen, lower alkyl, lower alkylenearyl, lower alkylenephenyl, lower alkylenehydroxyphenyl, lower alkyleneamine, lower alkyleneaminoaryl, lower alkylaminohydroxyphenyl, or a similar functional group. R5 is hydrogen, hydroxyl or methyl; R6 is hydrogen, lower alkyl, lower alkylenaryl, lower alkylenephenyl, lower alkylenehydroxyphenyl, lower alkyleneamine, lower alkyleneaminoaryl, lower alkylaminohydroxyphenyl, and the like. For both Formula I and Formual II, the first carbon on the side chain progressing from the ring is preferably in the R-configuration. The second carbon atom on the side chain of Formula II, which is attached to R5, may or may not be a chiral center. However, when the second carbon atom is a chiral center, it is preferably in the S-configuration. The present invention contemplates each stereoisomer of Formula I and II in substantially-pure form. The present invention also provides methods of relieving nasal, sinus and bronchial congestion and of treating attention deficit hyperactivity disorder and obesity. The present stereoisomers may also be used to induce pupil dilation. These methods include administering to a mammal a composition containing a therapeutically effective amount of a stereoscopically-pure stereoisomer of Formula I or II with a pharmaceutically acceptable excipient.