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138 条记录 (耗时 0.035 秒)

    Treatment of disorders secondary to organic impairments
    2.
    发明授权
    Treatment of disorders secondary to organic impairments 失效
    治疗继发于有机损伤的疾病

    公开(公告)号：US06696495B2

    公开(公告)日：2004-02-24

    申请号：US10092144

    申请日：2002-03-06

    申请人： Peter Sterling Mueller

    发明人： Peter Sterling Mueller

    IPC分类号： A61K31135

    CPC分类号： A61K31/135 ,  A61K31/00

    摘要： A method for treatment of neuropsychiatric symptoms or disorders emanating from primary brain or systemic impairments includes administration of an effective dose of a dopamine, serotonin, and norepinephrine reuptake inhibitor to a human in need of such treatment. The preferred reuptake inhibitor is sibutramine.

    摘要翻译： 用于治疗从原发性脑部或全身损伤引起的神经精神症状或障碍的方法包括向需要这种治疗的人施用有效剂量的多巴胺，5-羟色胺和去甲肾上腺素再摄取抑制剂。 优选的再摄取抑制剂是西布曲明。

    Soluble compositions of triphenylethylene antiestrogens
    4.
    发明授权
    Soluble compositions of triphenylethylene antiestrogens 有权
    三苯乙烯抗雌激素的可溶组合物

    公开(公告)号：US06632841B1

    公开(公告)日：2003-10-14

    申请号：US09868179

    申请日：2001-10-02

    申请人： Kaija Af Ursin ,  Jukka Salmia ,  Heikki Niskanen ,  Pirjo Kortesuo ,  Mikko Kananen ,  Gunilla Örn ,  Juha Kiesvaara

    发明人： Kaija Af Ursin ,  Jukka Salmia ,  Heikki Niskanen ,  Pirjo Kortesuo ,  Mikko Kananen ,  Gunilla Örn ,  Juha Kiesvaara

    IPC分类号： A61K31135

    CPC分类号： A61K47/12 ,  A61K47/20

    摘要： Aqueous compositions of nonsteroidal triphenylethylene antiestrogens for pharmaceutical use comprising as a solubility enhancing agent a pharmaceutically acceptable mono- or dicarboxylic acid having 1-5 carbon atoms, wherein the carbon chain may further contain 1-4 hydroxyl, 1-3 oxo, or one or several halogen a substituents, or a corresponding anion thereof, or methanesulfonic acid or its corresponding anion, in molar excess with respect to the triphenylethylene antiestrogen, optionally together with an organic water miscible co-solvent such as polyethylene glycol (PEG), propylene glycol, ethanol or isopropanol.

    摘要翻译： 用于药物用途的非甾体三苯乙烯抗雌激素的水性组合物，其包含具有1-5个碳原子的药学上可接受的单羧酸或二羧酸作为溶解度增强剂，其中所述碳链还可含有1-4个羟基，1-3个氧代或一个或 几个卤素相对于三苯乙烯抗雌激素以摩尔过量的取代基或其相应的阴离子或甲磺酸或其相应的阴离子，任选与有机水混溶性共溶剂如聚乙二醇（PEG），丙二醇， 乙醇或异丙醇

    Method for preventing and treating peripheral neuropathy by administering selegiline
    5.
    发明授权
    Method for preventing and treating peripheral neuropathy by administering selegiline 失效
    通过施用司来吉兰预防和治疗周围神经病变的方法

    公开(公告)号：US06538036B2

    公开(公告)日：2003-03-25

    申请号：US10225522

    申请日：2002-08-21

    申请人： George Bobotas

    发明人： George Bobotas

    IPC分类号： A61K31135

    CPC分类号： A61K31/337 ,  A61K31/137 ,  A61K31/475 ,  A61K33/24 ,  Y02A50/401 ,  A61K2300/00

    摘要： The present invention is directed to methods for alleviating the symptoms associated with peripheral neuropathy. The neuropathy may be the result of a genetically inherited condition, systemic disease or exposure to a toxic agent. A reduction or elimination of symptoms is obtained by administering the drug selegiline. The invention is also directed to a method for treating patients with cancer by administering a chemotherapeutic agent known to have a toxic affect on peripheral nerves together with selegiline.

    摘要翻译： 本发明涉及减轻与周围神经病变相关的症状的方法。 神经病可能是遗传性遗传病，全身性疾病或暴露于毒性剂的结果。 通过施用药物司来吉兰获得症状的减轻或消除。 本发明还涉及一种治疗癌症患者的方法，该治疗剂与司来吉兰一起施用已知对周围神经具有毒性作用的化学治疗剂。

    (−)-Pseudoephedrine as a sympathomimetic drug
    6.
    发明授权
    (−)-Pseudoephedrine as a sympathomimetic drug 有权
    （ - ） - 伪麻黄素作为拟交感神经药物

    公开(公告)号：US06495529B1

    公开(公告)日：2002-12-17

    申请号：US09743052

    申请日：2001-04-16

    申请人： Anthony Booth ,  William T. Sherman ,  Peter Raven ,  James L. Caffrey ,  Thomas Yorio ,  Michael Forster ,  Patricia Gwirtz

    发明人： Anthony Booth ,  William T. Sherman ,  Peter Raven ,  James L. Caffrey ,  Thomas Yorio ,  Michael Forster ,  Patricia Gwirtz

    IPC分类号： A61K31135

    CPC分类号： A61K31/137 ,  Y10S514/912

    摘要： The present invention provides pharmaceutical compositions which include (−)-pseudoephedrine and a pharmaceutically acceptable carrier, wherein the (−)-pseudoephedrine is substantially-free of (+)-pseudoephedrine. In another embodiment, the present invention provides methods of relieving nasal and bronchial congestion and of inducing pupil dilation which include administering a pharmaceutically effective amount of (−)-pseudoephedrine to a mammal. The (−)-pseudoephedrine used in the present methods is substantially free of (+)-pseudoephedrine and also substantially free of side effects caused by administration of (+)-pseudoephedrine.

    摘要翻译： 本发明提供包含（ - ） - 伪麻黄碱和药学上可接受的载体的药物组合物，其中（ - ） - 伪麻黄碱基本上不含（+） - 伪麻黄碱。 在另一个实施方案中，本发明提供减轻鼻和支气管充血并诱导瞳孔扩张的方法，其包括向哺乳动物施用药学有效量的（ - ） - 伪麻黄碱。 本方法中使用的（ - ） - 伪麻黄素基本上不含（+） - 伪麻黄碱，并且基本上没有由（+） - 伪麻黄碱施用引起的副作用。

    Treatments using venlafaxine
    7.
    发明授权
    Treatments using venlafaxine 失效
    使用文拉法辛治疗

    公开(公告)号：US06465524B2

    公开(公告)日：2002-10-15

    申请号：US09892363

    申请日：2001-06-27

    申请人： Richard L. Rudolph ,  Albert T. Derivan ,  Eric A. Muth ,  G. Virginia Upton

    发明人： Richard L. Rudolph ,  Albert T. Derivan ,  Eric A. Muth ,  G. Virginia Upton

    IPC分类号： A61K31135

    CPC分类号： A61K31/137 ,  A61K31/135

    摘要： This invention provides a method of treating obesity, generalized anxiety disorder, post-traumatic stress disorder, late luteal phase disphoric disorder (premenstrual syndrome), attention deficit disorder, with and without hyperactivity, Gilles de la Tourette syndrome, bulimia nervosa or Shy Drager Syndrome in a mammal by administering to the mammal an effective amount of a hydroxycycloalkanephenethyl amine of the following structural formula: in which A is a moiety of the formula where the dotted line represents optional unsaturation; R1 is hydrogen or alkyl; R2 is alkyl; R4 is hydrogen, alkyl, formyl, or alkanol; R5 and R6 are, independently, hydrogen, hydroxyl, alkyl, alkoxy, alkanoyloxy, cyano, nitro, alkylmercapto, amino, alkylamino, dialkylamino, alkanamido, halo, trifluoromethyl, or taken together, methylene dioxy; R7 is hydrogen or alkyl; and n is 0, 1, 2, 3, or 4; or a pharmaceutically acceptable salt thereof.

    摘要翻译： 本发明提供一种治疗肥胖症，广泛性焦虑症，创伤后应激障碍，晚黄体期无症状（经前期综合征），注意缺陷障碍，伴有和不伴有多动症的方法，Gilles de la Tourette综合征，神经性贪食症或Shy Drager综合征 在哺乳动物中通过向哺乳动物施用有效量的以下结构式的羟基环烷基苯乙胺：其中A是缬氨酸的部分，虚线代表任选的不饱和基团; R 1是氢或烷基; R 2是烷基; R 4是氢， 烷基，烷基或链烷醇; R 5和R 6独立地是氢，羟基，烷基，烷氧基，烷酰氧基，氰基，硝基，烷基巯基，氨基，烷基氨基，二烷基氨基，烷酰氨基，卤素，三氟甲基， 是氢或烷基; 和n为0,1,2,3或4;或其药学上可接受的盐。

    Deprenyl compounds for treatment of glaucoma
    9.
    发明授权
    Deprenyl compounds for treatment of glaucoma 失效
    用于治疗青光眼的Dep yl yl啶化合物

    公开(公告)号：US06455590B1

    公开(公告)日：2002-09-24

    申请号：US09374455

    申请日：1999-08-13

    申请人： William G. Tatton

    发明人： William G. Tatton

    IPC分类号： A61K31135

    CPC分类号： A61K31/137 ,  A61K31/135 ,  Y10S514/913

    摘要： Methods and kits for treament of glaucoma are disclosed. In general, the methods of the invention include administering a therapeutically effective amount of a deprenyl compound to a subject such that the subject is treated for glaucoma.

    摘要翻译： 公开了治疗青光眼的方法和试剂盒。 通常，本发明的方法包括向受试者施用治疗有效量的去肾上腺素化合物，使得受试者被治疗青光眼。

    Surgical irrigation solution and method for inhibition of pain and inflammation
    10.
    发明授权
    Surgical irrigation solution and method for inhibition of pain and inflammation 有权
    手术灌注液和抑制疼痛和炎症的方法

    公开(公告)号：US06420432B2

    公开(公告)日：2002-07-16

    申请号：US09837141

    申请日：2001-04-17

    申请人： Gregory A. Demopulos ,  Pamela A. Pierce ,  Jeffrey M. Herz

    发明人： Gregory A. Demopulos ,  Pamela A. Pierce ,  Jeffrey M. Herz

    IPC分类号： A61K31135

    CPC分类号： A61K31/439 ,  A61K31/00 ,  A61K31/352 ,  A61K31/40 ,  A61K31/4045 ,  A61K31/4164 ,  A61K31/4168 ,  A61K31/4174 ,  A61K31/435 ,  A61K31/4406 ,  A61K31/4427 ,  A61K31/4439 ,  A61K31/444 ,  A61K31/48 ,  A61K31/498 ,  A61K31/505 ,  A61K31/506 ,  A61K31/538 ,  A61K45/06 ,  Y10S977/738 ,  Y10S977/904 ,  Y10S977/916 ,  Y10S977/919

    摘要： A method and solution for perioperatively inhibiting a variety of pain and inflammation processes at wounds from general surgical procedures including oral/dental procedures. The solution preferably includes multiple pain and inflammation inhibitory at dilute concentration in a physiologic carrier, such as saline or lactated Ringer's solution. The solution is applied by continuous irrigation of a wound during a surgical procedure for preemptive inhibition of pain and while avoiding undesirable side effects associated with oral, intramuscular, subcutaneous or intravenous application of larger doses of the agents. One preferred solution to inhibit pain and inflammation includes a serotonin2 antagonist, a serotonin3 antagonist, a histamine antagonist, a serotonin agonist, a cyclooxygenase inhibitor, a neurokinin1 antagonist, a neurokinin2 antagonist, a purinoceptor antagonist, an ATP-sensitive potassium channel opener, a calcium channel antagonist, a bradykinin1 antagonist, a bradykinin2 antagonist and a &mgr;-opioid agonist.

    摘要翻译： 一种围手术期抑制来自一般外科手术（包括口腔/牙科手术）的伤口的各种疼痛和炎症过程的方法和解决方案。 该溶液优选包括在生理载体例如盐水或乳酸林格氏溶液中以稀释浓度抑制的多种疼痛和炎症。 在外科手术过程中连续冲洗伤口以解决疼痛的预防性作用，同时避免与口服，肌肉内，皮下或静脉内施用较大剂量的药剂相关的不良副作用。 抑制疼痛和炎症的一个优选的解决方案包括5-羟色胺2拮抗剂，5-羟色胺3拮抗剂，组胺拮抗剂，5-羟色胺激动剂，环加氧酶抑制剂，神经激肽1拮抗剂，神经激肽2拮抗剂，嘌呤受体拮抗剂，ATP-敏感钾通道开放剂， 钙通道拮抗剂，缓激肽1拮抗剂，缓激肽2拮抗剂和μ-阿片样物质激动剂。