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公开(公告)号:US08106169B2
公开(公告)日:2012-01-31
申请号:US10536875
申请日:2003-11-28
申请人: Kristen Briggs , Todd Glancy , Mich B. Hein , Andrew C. Hiatt , Anton S. Karnoup , W. H. Kerr Anderson , Dayakar Pareddy , Joseph Petolino , Beth Rubin-Wilson , Doug Taylor , Jean L. Roberts
发明人: Kristen Briggs , Todd Glancy , Mich B. Hein , Andrew C. Hiatt , Anton S. Karnoup , W. H. Kerr Anderson , Dayakar Pareddy , Joseph Petolino , Beth Rubin-Wilson , Doug Taylor , Jean L. Roberts
CPC分类号: C12N15/8258 , A61K2039/505 , C07K16/00 , C07K16/087 , C07K16/2839 , C07K2317/13 , C07K2317/41
摘要: This invention provides for the plant production of immunoglobulins, wherein at least a portion of the glycans attached to the immunoglobulins lack fucose. The invention also provides the constructs; plasmids; vectors; transformed plant cells, transformed plant calli; transformed plant tissues (e.g., leaves, seeds, tubers, etc.); transformed whole plants used to produce such immunoglobulins; methods of producing the immunoglobulins; the immunoglobulins produced by the disclosed methods; and the use of such immunoglobulins.
摘要翻译: 本发明提供免疫球蛋白的植物生产,其中与免疫球蛋白连接的至少一部分聚糖缺乏岩藻糖。 本发明还提供了构建体; 质粒 向量 转化的植物细胞,转化植物愈伤组织; 转化的植物组织(例如叶,种子,块茎等); 转化用于产生这种免疫球蛋白的整个植物; 生产免疫球蛋白的方法; 通过公开的方法产生的免疫球蛋白; 以及使用这种免疫球蛋白。