公开(公告)号：US06190883B1

公开(公告)日：2001-02-20

申请号：US09392126

申请日：1999-09-08

申请人： Aradhana Srivastava ,  Jure Piskur ,  Jens Nielsen ,  Michi Egel-Mitani

发明人： Aradhana Srivastava ,  Jure Piskur ,  Jens Nielsen ,  Michi Egel-Mitani

IPC分类号： C12P2106

CPC分类号： C12N1/16 ,  C12P21/02

摘要： The invention describes industrial fermentation of a Saccharomyces yeast species for production of a heterologous product encoded by a plasmid or DNA contained in said Saccharomyces yeast species which method utilizes the substrate more efficiently and without fermentative metabolism resulting in formation of ethanol and other unwanted primary products of fermentative activity whereby high yields of the heterologous product are obtained. The Saccharomyces yeast species is preferably a Crabtree negative Saccharomyces species in particular Saccharomyces kluyveri.

摘要翻译： 本发明描述了酿酒酵母物种的工业发酵，用于生产由所述酵母属酵母菌种中含有的质粒或DNA编码的异源产物，该方法利用该底物更有效且无发酵代谢，从而形成乙醇和其它不需要的初级产物 发酵活性，从而获得高产量的异源产物。 酵母属酵母菌种优选是Crabtree阴性酵母菌种，特别是酵母菌（Saccharomyces kluyveri）。