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公开(公告)号:US20070122486A1
公开(公告)日:2007-05-31
申请号:US11698151
申请日:2007-01-26
摘要: Nanoparticulate insulin compositions having effective an average particle size of less than about 5 microns are described. The compositions exhibit retention of insulin bioactivity, increased bioavailability, and increased consistency of bioavailability as compared to prior macro-sized insulin compositions. Methods of making nanoparticulate insulin compositions, dosage forms containing them, and the use of such formulations in insulin therapy are also described.
摘要翻译: 描述了有效平均粒度小于约5微米的纳米微粒胰岛素组合物。 与现有的大尺寸胰岛素组合物相比,组合物表现出胰岛素生物活性的保留,生物利用度的提高和生物利用度的一致性的增加。 还描述了制备纳米微粒胰岛素组合物,含有它们的剂型以及在胰岛素治疗中使用这些制剂的方法。
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公开(公告)号:US20070004668A1
公开(公告)日:2007-01-04
申请号:US11509529
申请日:2006-08-23
申请人: Araz Raoof , Mangaraju Gudipati , David Bibby , Susan Reingold
发明人: Araz Raoof , Mangaraju Gudipati , David Bibby , Susan Reingold
CPC分类号: A61K9/0024 , A61K9/2013 , A61K9/4858 , A61K31/20 , A61K31/7088 , A61K38/00 , A61K47/12 , C12N15/113 , C12N15/1136 , C12N2310/315 , C12N2310/321 , A61K2300/00 , C12N2310/3525
摘要: A pharmaceutical composition comprising an antisense oligonucleotide and a permeation enhancer that comprises a multi-carbon backbone having a functional group and also one or more side chains which have one or more carbon atoms and, optionally, one or more functional groups.
摘要翻译: 包含反义寡核苷酸和渗透促进剂的药物组合物,其包含具有官能团的多碳骨架以及具有一个或多个碳原子的一个或多个侧链和任选的一个或多个官能团。
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