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公开(公告)号:US20070122486A1
公开(公告)日:2007-05-31
申请号:US11698151
申请日:2007-01-26
摘要: Nanoparticulate insulin compositions having effective an average particle size of less than about 5 microns are described. The compositions exhibit retention of insulin bioactivity, increased bioavailability, and increased consistency of bioavailability as compared to prior macro-sized insulin compositions. Methods of making nanoparticulate insulin compositions, dosage forms containing them, and the use of such formulations in insulin therapy are also described.
摘要翻译: 描述了有效平均粒度小于约5微米的纳米微粒胰岛素组合物。 与现有的大尺寸胰岛素组合物相比,组合物表现出胰岛素生物活性的保留,生物利用度的提高和生物利用度的一致性的增加。 还描述了制备纳米微粒胰岛素组合物,含有它们的剂型以及在胰岛素治疗中使用这些制剂的方法。