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1.发明授权公开(公告)号：US08871731B2
公开(公告)日：2014-10-28
申请号：US13422932
申请日：2012-03-16
IPC分类号： C12N15/11 , A61K31/7125 , C12N15/113 , A61K31/712
CPC分类号： A61K31/712 , A61K31/7125 , C12N15/113 , C12N2310/113
摘要： The present invention relates to treating or preventing age-related cardiomyopathy by modulating the expression or activity of a miR-34 family member and/or PNUTS. Methods of treating or preventing age-related cardiomyopathy include administering an inhibitor of miR-34 expression or activity or an agonist of PNUTS expression or activity. Also provided herein are methods of treating or preventing cardiac fibrosis and myocardial infarction by administering an inhibitor of miR-34 expression or activity or an agonist of PNUTS expression or activity.
摘要翻译： 本发明涉及通过调节miR-34家族成员和/或PNUTS的表达或活性来治疗或预防年龄相关性心肌病。 治疗或预防年龄相关性心肌病的方法包括施用miR-34表达或活性的抑制剂或PNUTS表达或活性的激动剂。 本文还提供了通过施用miR-34表达或活性的抑制剂或PNUTS表达或活性的激动剂来治疗或预防心脏纤维化和心肌梗死的方法。
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2.发明申请公开(公告)号：US20120238619A1
公开(公告)日：2012-09-20
申请号：US13422932
申请日：2012-03-16
IPC分类号： A61K31/7088 , A61P9/10 , A61P9/00
CPC分类号： A61K31/712 , A61K31/7125 , C12N15/113 , C12N2310/113
摘要： The present invention relates to treating or preventing age-related cardiomyopathy by modulating the expression or activity of a miR-34 family member and/or PNUTS. Methods of treating or preventing age-related cardiomyopathy include administering an inhibitor of miR-34 expression or activity or an agonist of PNUTS expression or activity. Also provided herein are methods of treating or preventing cardiac fibrosis and myocardial infarction by administering an inhibitor of miR-34 expression or activity or an agonist of PNUTS expression or activity.
摘要翻译： 本发明涉及通过调节miR-34家族成员和/或PNUTS的表达或活性来治疗或预防年龄相关性心肌病。 治疗或预防年龄相关性心肌病的方法包括施用miR-34表达或活性的抑制剂或PNUTS表达或活性的激动剂。 本文还提供了通过施用miR-34表达或活性的抑制剂或PNUTS表达或活性的激动剂来治疗或预防心脏纤维化和心肌梗死的方法。
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