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公开(公告)号:US09518098B2
公开(公告)日:2016-12-13
申请号:US14128882
申请日:2012-06-25
申请人: Ariel Ruiz Altaba
发明人: Ariel Ruiz Altaba
IPC分类号: C07K19/00 , C07H21/02 , C07K14/435 , A61K31/7105 , A61K31/166 , A61K31/175 , A61K31/495 , A61K31/7088 , A61K38/12 , A61K38/17 , A61K39/395
CPC分类号: C07K14/435 , A61K31/166 , A61K31/175 , A61K31/495 , A61K31/7088 , A61K31/7105 , A61K38/12 , A61K38/17 , A61K39/39533
摘要: The present invention relates to substances and compositions thereof useful in the control of cancer stem cell persistence and concomitant tumor recurrence and/or control of tumor growth. In particular, the invention relates to substances and compositions useful in the treatment of cancers and/or tumors linked to cancer stem cells, preferably brain cancers and/or tumors, in a subject.
摘要翻译: 本发明涉及可用于控制癌症干细胞持久性和伴随的肿瘤复发和/或控制肿瘤生长的物质及其组合物。 特别地,本发明涉及可用于治疗与受试者中的癌症干细胞,优选脑癌和/或肿瘤连接的癌症和/或肿瘤的物质和组合物。
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公开(公告)号:US09351988B2
公开(公告)日:2016-05-31
申请号:US14115410
申请日:2012-05-01
申请人: Ariel Ruiz Altaba , Christophe Mas
发明人: Ariel Ruiz Altaba , Christophe Mas
IPC分类号: A61K31/7048 , A61K31/365 , A61K45/06
CPC分类号: A61K31/7048 , A61K31/365 , A61K45/06
摘要: The present invention is directed to the use of macrocyclic lactones, in particular avermectins, in the treatment of conditions whose formation, occurrence, development or growth is associated with aberrant Wnt signalling, in particular the treatment of colorectal cancer.
摘要翻译: 本发明涉及大环内酯,特别是阿维菌素在治疗其形成,发生,发展或生长与异常Wnt信号传导,特别是治疗结肠直肠癌相关的病症中的用途。
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公开(公告)号:US20140147440A1
公开(公告)日:2014-05-29
申请号:US14128882
申请日:2012-06-25
申请人: Ariel Ruiz Altaba
发明人: Ariel Ruiz Altaba
IPC分类号: C07K14/435 , A61K39/395 , A61K31/7088 , A61K31/166 , A61K31/175 , A61K38/12 , A61K38/17 , A61K31/495
CPC分类号: C07K14/435 , A61K31/166 , A61K31/175 , A61K31/495 , A61K31/7088 , A61K31/7105 , A61K38/12 , A61K38/17 , A61K39/39533
摘要: The present invention relates to substances and compositions thereof useful in the control of cancer stem cell persistence and concomitant tumor recurrence and/or control of tumor growth. In particular, the invention relates to substances and compositions useful in the treatment of cancers and/or tumors linked to cancer stem cells, preferably brain cancers and/or tumors, in a subject.
摘要翻译: 本发明涉及可用于控制癌症干细胞持久性和伴随的肿瘤复发和/或控制肿瘤生长的物质及其组合物。 特别地,本发明涉及可用于治疗与受试者中的癌症干细胞,优选脑癌和/或肿瘤连接的癌症和/或肿瘤的物质和组合物。
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公开(公告)号:US20140080779A1
公开(公告)日:2014-03-20
申请号:US14115410
申请日:2012-05-01
申请人: Ariel Ruiz Altaba , Christophe Mas
发明人: Ariel Ruiz Altaba , Christophe Mas
IPC分类号: A61K31/7048 , A61K31/365 , A61K45/06
CPC分类号: A61K31/7048 , A61K31/365 , A61K45/06
摘要: The present invention is directed to the use of macrocyclic lactones, in particular avermectins, in the treatment of conditions whose formation, occurrence, development or growth is associated with aberrant Wnt signalling in particular the treatment of colorectal cancer.
摘要翻译: 本发明涉及大环内酯,特别是阿维菌素在治疗其形成,发生,发展或生长与异常Wnt信号传导特别是结肠直肠癌治疗相关的病症中的用途。
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