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    Methods for detecting epigenetic modifications
    1.
    发明授权
    Methods for detecting epigenetic modifications 有权
    检测表观遗传修饰的方法

    公开(公告)号：US08969046B2

    公开(公告)日：2015-03-03

    申请号：US12522648

    申请日：2008-01-09

    申请人： Manon Van Engeland ,  Manon Adriaan De Bruine ,  Arjan Griffioen ,  Joost Louwagie ,  Katja Bierau ,  Gontran Brichard ,  Gaëtan Otto ,  Maarten Penning

    发明人： Manon Van Engeland ,  Manon Adriaan De Bruine ,  Arjan Griffioen ,  Joost Louwagie ,  Katja Bierau ,  Gontran Brichard ,  Gaëtan Otto ,  Maarten Penning

    IPC分类号： C12Q1/68 ,  C12P19/34 ,  C07H21/02

    CPC分类号： C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/112 ,  C12Q2600/118 ,  C12Q2600/154 ,  C12Q2600/158 ,  C12Q2600/16

    摘要： A method of detecting a predisposition to, or the incidence of, cancer in a sample comprises detecting an epigenetic change in at least one gene selected from an NDRG4/NDRG2 subfamily gene, GATA4, OSMR, GATA5, SFRP1, ADAM23, JPH3, SFRP2, APC, MGMT, TFPI2, BNIP3, FOXE1, SYNE1, S0X17, PHACTR3 and JAM3, wherein detection of the epigenetic change is indicative of a predisposition to, or the incidence of, cancer. Also described are pharmacogenetic methods for determining suitable treatment regimens for cancer and methods for treating cancer patients, based around selection of the patients according to the methods of the invention. The present invention is also concerned with improved methods of collecting, processing and analyzing samples, in particular body fluid samples. These methods may be useful in diagnosing, staging or otherwise characterizing various diseases. The invention also relates to methods for identifying, diagnosing, staging or otherwise characterizing cancers, in particular gastrointestinal cancers such as colorectal cancers, gastric cancers and oesophageal cancers. The methods of the invention relate, inter alia, to isolating and analyzing the human DNA component from faecal samples and blood-based samples.

    摘要翻译： 检测样品中的癌症的倾向或发生率的方法包括检测选自NDRG4 / NDRG2亚家族基因，GATA4，OSMR，GATA5，SFRP1，ADAM23，JPH3，SFRP2中的至少一种基因的表观遗传学变化， APC，MGMT，TFPI2，BNIP3，FOXE1，SYNE1，S0X17，PHACTR3和JAM3，其中表观遗传改变的检测指示癌症的倾向或发生率。 还描述了基于根据本发明的方法选择患者的用于确定癌症的合适治疗方案的药物遗传学方法和用于治疗癌症患者的方法。 本发明还涉及采集，加工和分析样品，特别是体液样品的改进方法。 这些方法可用于诊断，分期或以其他方式表征各种疾病。 本发明还涉及鉴定，诊断，分期或以其他方式表征癌症，特别是胃肠癌如结肠直肠癌，胃癌和食管癌的方法。 本发明的方法尤其涉及从粪便样品和血液样品中分离和分析人类DNA组分。

    Methods for Detecting Epigenetic Modifications
    2.
    发明申请
    Methods for Detecting Epigenetic Modifications 有权
    检测表观遗传修饰的方法

    公开(公告)号：US20100144836A1

    公开(公告)日：2010-06-10

    申请号：US12522648

    申请日：2008-01-09

    申请人： Manon Van Engeland ,  Manon Adriaan De Bruine ,  Arjan Griffioen ,  Joost Louwagie ,  Katja Bierau ,  Gontran Brichard ,  Gaëtan Otto ,  Maarten Penning

    发明人： Manon Van Engeland ,  Manon Adriaan De Bruine ,  Arjan Griffioen ,  Joost Louwagie ,  Katja Bierau ,  Gontran Brichard ,  Gaëtan Otto ,  Maarten Penning

    IPC分类号： A61K31/7088 ,  C12Q1/68 ,  A61P35/04 ,  C07H21/04

    CPC分类号： C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/112 ,  C12Q2600/118 ,  C12Q2600/154 ,  C12Q2600/158 ,  C12Q2600/16

    摘要： A method of detecting a predisposition to, or the incidence of, cancer in a sample comprises detecting an epigenetic change in at least one gene selected from an NDRG4/NDRG2 subfamily gene, GATA4, OSMR, GATA5, SFRP1, ADAM23, JPH3, SFRP2, APC, MGMT, 11112, BNIP3, FOXE1, SYNE1, S0X17, PHACTR3 and JAM3, wherein detection of the epigenetic change is indicative of a predisposition to, or the incidence of, cancer. Also described are pharmacogenetic methods for determining suitable treatment regimens for cancer and methods for treating cancer patients, based around selection of the patients according to the methods of the invention. The present invention is also concerned with improved methods of collecting, processing and analyzing samples, in particular body fluid samples. These methods may be useful in diagnosing, staging or otherwise characterizing various diseases. The invention also relates to methods for identifying, diagnosing, staging or otherwise characterizing cancers, in particular gastrointestinal cancers such as colorectal cancers, gastric cancers and oesophageal cancers. The methods of the invention relate, inter alia, to isolating and analyzing the human DNA component from faecal samples and blood-based samples.

    摘要翻译： 检测样品中的癌症倾向或发病率的方法包括检测选自NDRG4 / NDRG2亚家族基因，GATA4，OSMR，GATA5，SFRP1，ADAM23，JPH3，SFRP2中的至少一种基因的表观遗传学变化， APC，MGMT，11112，BNIP3，FOXE1，SYNE1，S0X17，PHACTR3和JAM3，其中表观遗传改变的检测指示癌症的倾向或发生率。 还描述了基于根据本发明的方法选择患者的用于确定癌症的合适治疗方案的药物遗传学方法和用于治疗癌症患者的方法。 本发明还涉及采集，加工和分析样品，特别是体液样品的改进方法。 这些方法可用于诊断，分期或以其他方式表征各种疾病。 本发明还涉及鉴定，诊断，分期或以其他方式表征癌症，特别是胃肠癌如结肠直肠癌，胃癌和食管癌的方法。 本发明的方法尤其涉及从粪便样品和血液样品中分离和分析人类DNA组分。