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公开(公告)号：US06653444B1
公开(公告)日：2003-11-25
申请号：US08453386
申请日：1995-05-30
IPC分类号： C07K14705
CPC分类号： C07K14/70532 , A01K2217/075
摘要： Isolated nucleic acid molecules encoding a B cell activation antigen, B7, are provided. In one embodiment, the nucleic acid molecules are DNA sequences. The DNA sequences of the invention can be integrated into various expression vectors, which in turn can direct the synthesis of the corresponding proteins or peptides in a variety of hosts, particularly eukaryotic cells, such as mammalian and insect cell culture. Also provided are host cells transformed to produce proteins or peptides encoded by the DNA molecules of the present invention and purified proteins and peptides which comprise at least a portion of the B cell activation antigen. The proteins and peptides comprise at least a portion of the mature form of the B7 activation antigen and preferably comprise a soluble form of the B7 protein.
摘要翻译： 提供编码B细胞活化抗原B7的分离的核酸分子。 在一个实施方案中，核酸分子是DNA序列。 本发明的DNA序列可以整合到各种表达载体中，这又可以引导各种宿主，特别是真核细胞如哺乳动物和昆虫细胞培养物中相应的蛋白质或肽的合成。 还提供了转化以产生由本发明的DNA分子编码的蛋白质或肽的宿主细胞和包含至少一部分B细胞活化抗原的纯化的蛋白质和肽。 蛋白质和肽包含至少一部分成熟形式的B7活化抗原，并且优选包含可溶形式的B7蛋白。
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2.发明授权DNA encoding, B7, a new member of the IG superfamily with unique expression on activated and neoplastic B cells 失效DNA编码，B7，在活化和肿瘤B细胞上具有独特表达的IG超家族的新成员
公开(公告)号：US6071716A
公开(公告)日：2000-06-06
申请号：US153262
申请日：1993-11-15
IPC分类号： C07K14/705 , C12N15/12 , C12N15/00
CPC分类号： C07K14/70532 , A01K2217/075
摘要： Isolated nucleic acid molecules encoding a B cell activation antigen, B7, are provided. In one embodiment, the nucleic acid molecules are DNA sequences. The DNA sequences of the invention can be integrated into various expression vectors, which in turn can direct the synthesis of the corresponding proteins or peptides in a variety of hosts, particularly eukaryotic cells, such as mammalian and insect cell culture. Also provided are host cells transformed to produce proteins or peptides encoded by the DNA molecules of the present invention and purified proteins and peptides which comprise at least a portion of the B cell activation antigen. The proteins and peptides comprise at least a portion of the mature form of the B7 activation antigen and preferably comprise a soluble form of the B7 protein.
摘要翻译： 提供编码B细胞活化抗原B7的分离的核酸分子。 在一个实施方案中，核酸分子是DNA序列。 本发明的DNA序列可以整合到各种表达载体中，这又可以引导各种宿主，特别是真核细胞如哺乳动物和昆虫细胞培养物中相应的蛋白质或肽的合成。 还提供了转化以产生由本发明的DNA分子编码的蛋白质或肽的宿主细胞和包含至少一部分B细胞活化抗原的纯化的蛋白质和肽。 蛋白质和肽包含至少一部分成熟形式的B7活化抗原，并且优选包含可溶形式的B7蛋白。
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