公开(公告)号：US4572914A

公开(公告)日：1986-02-25

申请号：US163767

申请日：1980-06-27

申请人： Roelof van Hes ,  Arnoldus C. Grosscurt

发明人： Roelof van Hes ,  Arnoldus C. Grosscurt

IPC分类号： A01N43/56 ,  A01N47/38 ,  C07D231/06 ,  C07D231/08

CPC分类号： C07D231/06 ,  A01N47/38

摘要： The invention relates to new pyrazoline derivatives and to insecticidal compositions on the basis of the compounds.The compositions can be used for controlling insects in a dosage from 0.01 to 1 kg of active substance per hectare.

摘要翻译： 本发明涉及新的吡唑啉衍生物和基于该化合物的杀虫组合物。 该组合物可用于以每公顷0.01至1kg活性物质的剂量控制昆虫。

公开(公告)号：US5164396A

公开(公告)日：1992-11-17

申请号：US693863

申请日：1991-05-01

申请人： Arnoldus C. Grosscurt ,  Jan W. Terpstra

发明人： Arnoldus C. Grosscurt ,  Jan W. Terpstra

IPC分类号： A01N43/54 ,  C07D239/62 ,  C07D401/04 ,  C07D403/04 ,  C07D409/04 ,  C07D413/04 ,  C07D417/04

CPC分类号： C07D239/62 ,  A01N43/54

摘要： The invention relates to new barbituric acid derivatives of the general formula ##STR1## wherein R is a substituted or unsubstituted phenyl group or heteroaryl group having 5 or 6 ring atoms, the heteroaryl group comprising one or more hetero atoms selected from the group consisting of N, O and S, and the substituents being selected from the group consisting of halogen, cyano, nitro, formyl, acetyl, C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 haloalkyl, C.sub.1 -C.sub.4 alkoxy, C.sub.1 -C.sub.4 haloalkoxy and optionally substituted phenoxy;R.sub.1 is a C.sub.3 -C.sub.5 alkyl group, a C.sub.3 -C.sub.5 alkenyl group, a C.sub.3 -C.sub.5 alkynyl group, a cyclopropyl group or a cyclopropyl(C.sub.1 -C.sub.4)alkyl group, andR.sub.2 is a C.sub.1 -C.sub.4 alkyl group or an amino group;as well as salts and metal complexes of the said compounds.These compounds may be used in compositions for the control of insects, in particular aphids, in agriculture, horticulture and silviculture.

公开(公告)号：US4656193A

公开(公告)日：1987-04-07

申请号：US778433

申请日：1985-09-20

申请人： Marius S. Brouwer ,  Arnoldus C. Grosscurt ,  Roelof van Hes

发明人： Marius S. Brouwer ,  Arnoldus C. Grosscurt ,  Roelof van Hes

IPC分类号： A01N47/34 ,  A01P7/04 ,  C07C273/18 ,  C07C275/54 ,  C07C127/22

CPC分类号： A01N47/34

摘要： The invention relates to new benzoylurea compounds of the general formula ##STR1## wherein R.sub.1 is a hydrogen atom or represents 1 or 2 substituents which are selected from the group consisting of halogen and alkyl and haloalkyl having 1-4 carbon atoms,R.sub.2 is a hydrogen atom or represents 1 or 2 substituents which are selected from the group consisting of chlorine, methyl and trifluoromethyl, andR.sub.3 is a hydrogen atom or represents 1-3 alkyl and/or alkenyl groups each having 1-6 and/or 2-6 carbon atoms respectively,or wherein R.sub.3 together with the cyclohexyl ring to which it is attached forms a bi- or polycyclic hydrocarbyl group having 8-14 carbon atoms and, if desired, substituted with 1-3 alkyl groups each having 1-4 carbon atoms.The compounds have an insecticidal and acaricidal activity. After having been processed to compositions, the compounds may be used for the control of insects and/or mites in a dosage from 1 to 5000 g of active substance per hectare.

摘要翻译： 本发明涉及通式为“IMAGE”的新的苯甲酰脲化合物，其中R 1是氢原子或代表1或2个选自卤素和具有1-4个碳原子的烷基和卤代烷基的取代基，R 2是氢 原子或表示1或2个选自氯，甲基和三氟甲基的取代基，R3为氢原子或表示1-3个分别具有1-6个碳原子和/或2-6个碳原子的烷基和/或烯基基团 或其中R 3与其所连接的环己基环一起形成具有8-14个碳原子的双或多环烃基，如果需要，由1-3个分别具有1-4个碳原子的烷基取代。 这些化合物具有杀虫和杀螨活性。 经处理成组合物后，化合物可用于以每公顷1至5000克活性物质的剂量控制昆虫和/或螨虫。

公开(公告)号：US4609676A

公开(公告)日：1986-09-02

申请号：US759321

申请日：1985-07-26

申请人： Marius S. Brouwer ,  Arnoldus C. Grosscurt

发明人： Marius S. Brouwer ,  Arnoldus C. Grosscurt

IPC分类号： A61K31/17 ,  A01N47/34 ,  A01P7/02 ,  C07C67/00 ,  C07C239/00 ,  C07C251/50 ,  C07C275/54 ,  C07C325/00 ,  C07C335/26 ,  C07D213/53 ,  A01N43/40 ,  A01N47/28

CPC分类号： C07D213/53 ,  A01N47/34 ,  C07C275/54

摘要： The invention relates to new benzoylurea compounds of the general formula ##STR1## wherein R.sub.1 is a halogen atom,R.sub.2 is a hydrogen atom or a halogen atom,R.sub.3 is a hydrogen atom or represents 1 or 2 substituents which are selected from the group consisting of chlorine, methyl and trifluoromethyl,R.sub.4 is a hydrogen atom, an alkyl group having 1-6 carbon atoms or a cycloalkyl group having 3-6 carbon atoms,R.sub.5 is a hydrogen atom or an alkyl group having 1-4 carbon atoms, andA is a phenyl group or a heteroaryl group having 1 or 2 nitrogen atoms, which groups may be substituted with 1-3 substituents which are selected from the group consisting of halogen, and alkyl, alkoxy, haloalkyl and haloalkoxy having 1-4 carbon atoms.The compounds have an insecticidal and acaricidal activity. After having been processed to compositions, the compounds may be used for control of insects and/or mites in a dosage from 1 to 5000 g of active substance per hectare. In addition the compounds have an anti-tumor activity and may be used in pharmaceutical compositions.

公开(公告)号：US4783485A

公开(公告)日：1988-11-08

申请号：US912169

申请日：1986-09-26

申请人： Marius S. Brouwer ,  Arnoldus C. Grosscurt ,  Roelof Van Hes

发明人： Marius S. Brouwer ,  Arnoldus C. Grosscurt ,  Roelof Van Hes

IPC分类号： A01N47/34 ,  A01N47/36 ,  C07D213/75 ,  C07C127/22

CPC分类号： C07D213/75 ,  A01N47/34 ,  A01N47/36

摘要： The invention relates to new benzoylurea compounds having insecticidal and acaricidal activity, of the general formula ##STR1## wherein R.sub.1 is a hydrogen atom or represents 1 or 2 halogen atoms;Ar is a para-phenylene group or a para-pyridylene group, which groups may be substituted with 1 or 2 substituents selected from the group consisting of chlorine, methyl and trifluoromethyl;B is an oxygen atom or represents a group having the formula ##STR2## wherein R.sub.2 is a hydrogen atom or an alkyl group having 1-4 carbon atoms; andR is a cycloalkyl group or a cycloalkenyl group having 6-12 carbon atoms, which groups may be substituted with 1-3 substituents selected from the group consisting of alkyl and alkenyl having 1-6 carbon atoms, or whereinR is a bi- or polycyclic, saturated or unsaturated, hydrocarbyl group, having 8-14 carbon atoms and, if desired, substituted with 1-3 substituents selected from the group consisting of alkyl and alkenyl having 1-6 carbon atoms;with the proviso, that,if Ar is a whether or not substituted para-phenylene group, andR is a whether or not substituted cyclohexyl-group, or a saturated bi- or polycyclic hydrocarbyl group having 8-14 carbon atoms, then B does not represent an oxygen atom.

摘要翻译： 本发明涉及具有杀虫和杀螨活性的新的苯甲酰脲化合物，通式为其中R 1为氢原子或表示1或2个卤原子的通式（Ⅰ） Ar是对亚苯基或对 - 亚吡啶基，该基团可以被1或2个选自氯，甲基和三氟甲基的取代基取代; B是氧原子，或表示具有式“IMAGE”的基团，其中R2是氢原子或具有1-4个碳原子的烷基; 并且R是具有6-12个碳原子的环烷基或环烯基，该基团可以被选自具有1-6个碳原子的烷基和烯基的1-3个取代基取代，或其中R是双 - 或具有8-14个碳原子的多环，饱和或不饱和的烃基，如果需要，被1-3个选自具有1-6个碳原子的烷基和烯基的取代基取代; 条件是，如果Ar是否为取代的对亚苯基，R为无取代的环己基，还是具有8-14个碳原子的饱和双环或多环烃基，则B为 不代表氧原子。

公开(公告)号：US4710516A

公开(公告)日：1987-12-01

申请号：US932296

申请日：1986-11-19

申请人： Marius S. Brouwer ,  Arnoldus C. Grosscurt

发明人： Marius S. Brouwer ,  Arnoldus C. Grosscurt

IPC分类号： A61K31/17 ,  A01N47/34 ,  A01P7/02 ,  A61P35/00 ,  C07C275/54 ,  A01N47/28

CPC分类号： C07C275/54 ,  A01N47/34

摘要： The invention relates to an insecticidal and acaricidal composition comprising a benzoylurea compound of the general formula ##STR1## wherein R.sub.1 is a halogen atom,R.sub.2 is a hydrogen atom, a methoxy group or a halogen atom,R.sub.3 is a hydrogen atom or represents 1 or 2 substituents which are selected from the group consisting of halogen, methyl and trifluoromethyl,R.sub.4 is a hydrogen atom or represents 1-3 substituents which are selected from the group consisting of halogen, C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 alkoxy, C.sub.1 -C.sub.4 haloalkyl and C.sub.1 -C.sub.4 haloalkoxy,X is an oxygen atom or a sulphur atom,n is 0 or 1, andR.sub.5 is a hydrogen atom, a C.sub.1 -C.sub.6 alkyl group, a C.sub.2 -C.sub.6 alkenyl group or a C.sub.3 -C.sub.6 cycloalkyl group,with the proviso, that, if n is 0 and R.sub.5 is a hydrogen atom, R.sub.3 is a hydrogen atom.The composition may be used for the control of insects and/or mites in a dosage of 1 to 5,000 grams of active substance per hectare.

公开(公告)号：US4665235A

公开(公告)日：1987-05-12

申请号：US572143

申请日：1984-01-19

申请人： Marius S. Brouwer ,  Arnoldus C. Grosscurt

发明人： Marius S. Brouwer ,  Arnoldus C. Grosscurt

IPC分类号： A61K31/17 ,  A01N47/34 ,  A01P7/02 ,  A61P35/00 ,  C07C275/54 ,  C07C127/22

CPC分类号： C07C275/54 ,  A01N47/34

摘要： The invention relates to new benzoylurea compounds of the general formula ##STR1## wherein R.sub.1 is a halogen atom,R.sub.2 is a hydrogen atom or a halogen atom,R.sub.3 is a hydrogen atom or represents 1 or 2 substituents which are selected from the group consisting of chlorine, methyl and trifluormethyl,R.sub.4 is a hydrogen atom or represents 1-3 substituents which are selected from the group consisting of halogen, and alkyl, alkoxy, haloalkyl and haloalkoxy, having 1-4 carbon atoms,X is N or CH,n is 0 or 1, andR.sub.5 is a hydrogen atom, an alkyl group having 1-6 carbon atoms, an alkenyl group having 2-6 carbon atoms, or a cycloalkyl group having 3-6 carbon atoms, with the proviso, that, if n is 0 and R.sub.5 is a hydrogen atom, R.sub.3 is a hydrogen atom.The compounds have an insecticidal and acaricidal activity. After having been processed to compositions, the compounds may be used for the control of insects and/or mites in a dosage of 1 to 5000 grams of active substance per hectare. In addition the compounds have an antitumor activity and may be used in pharmaceutical compositions.

摘要翻译： 本发明涉及通式为“IMAGE”的新的苯甲酰脲化合物，其中R 1为卤素原子，R 2为氢原子或卤素原子，R 3为氢原子或表示1或2个选自以下的取代基： 氯，甲基和三氟甲基，R4是氢原子或表示1-3个选自卤素和具有1-4个碳原子的烷基，烷氧基，卤代烷基和卤代烷氧基的取代基，X是N或CH，n 是0或1，R5是氢原子，具有1-6个碳原子的烷基，具有2-6个碳原子的烯基或具有3-6个碳原子的环烷基，条件是如果 n为0，R5为氢原子，R3为氢原子。 这些化合物具有杀虫和杀螨活性。 经处理成组合物后，化合物可用于以每公顷1至5000克活性物质的剂量控制昆虫和/或螨虫。 此外，化合物具有抗肿瘤活性并可用于药物组合物。

公开(公告)号：US4379157A

公开(公告)日：1983-04-05

申请号：US226533

申请日：1981-01-19

申请人： Roelof van Hes ,  Arnoldus C. Grosscurt ,  Wouter Balk

发明人： Roelof van Hes ,  Arnoldus C. Grosscurt ,  Wouter Balk

IPC分类号： C07D275/04 ,  A01N41/06 ,  A01N43/36 ,  A01N43/40 ,  A01N43/80 ,  C07C67/00 ,  C07C301/00 ,  C07C303/38 ,  C07C303/40 ,  C07C311/16 ,  C07D275/06

CPC分类号： C07D275/06 ,  A01N41/06 ,  A01N43/80

摘要： The invention relates to new sulphonyl compounds of the general formula ##STR1## wherein X is a halogen atom, a phenoxy group, or an alkyl group or alkoxy group having 1-4 carbon atoms and substituted, if desired, with halogen;R.sub.1 is a cyano group, andR.sub.2 is an amino group which, if desired, may be substituted with halogen, with one or two alkenyl groups or alkynyl groups having 2-6 carbon atoms or with one or two alkyl groups having 1-6 carbon atoms, which alkyl groups, together with the nitrogen atom to which they are bound, may form a saturated heterocyclic ring, which ring may also contain a second hetero atom selected from the group consisting of nitrogen, oxygen and sulphur, or which alkyl groups may be substituted with an alkoxy group, having 1-4 carbon atoms, or with a dialkylamino group having 2-6 carbon atoms the alkyl groups of which, together with the nitrogen atom to which they are bound, may form a saturated heterocyclic ring;or whereinR.sub.1 and R.sub.2 together form a S,S-dialkylsulphoximido group the alkyl groups of which comprise 1-4 carbon atoms, or a 1-amino-2-azavinylene group, of which the amino group is substituted, if desired, with a cycloalkylcarbamoyl group having 4-8 carbon atoms, an alkylcarbamoyl group having 2-5 carbon atoms, a dialkylamino group the alkyl group of which comprise 1-4 carbon atoms, or an alkyl group having 1-4 carbon atoms which alkyl group may be substituted with a hydroxy group or one or more halogen atoms;or whereinR.sub.1 and R.sub.2 together form a 1-imino-2-azaethylene group of which the ring nitrogen is substituted with an alkyl group or alkenyl group having 1-4 carbon atoms, and of which the imino group may be substituted with a substituted or non-substituted phenylcarbamoyl group,having aphicidal activity. After having been processed to compositions, the compounds may be used for the control of aphids in agriculture, horticulture and forestry in a dosage from 20 to 5,000 g of active substance per hectare.

公开(公告)号：US4567295A

公开(公告)日：1986-01-28

申请号：US572144

申请日：1984-01-19

申请人： Marius S. Brouwer ,  Arnoldus C. Grosscurt

发明人： Marius S. Brouwer ,  Arnoldus C. Grosscurt

IPC分类号： A61K31/17 ,  A01N47/34 ,  A61P35/00 ,  C07C275/54 ,  C07C323/44

CPC分类号： A01N47/34 ,  C07C275/54 ,  C07C323/44

摘要： The invention relates to a composition active against mites, whitefly and thrips, which comprises, in addition to a liquid or solid inert carrier material, a benzoylurea compound of the general formula ##STR1## wherein R.sub.1 is hydrogen atom or represents 1 or 2 substituents which are selected from the group consisting of chlorine, methyl and trifluoromethyl,R.sub.2 is an alkyl group having 2-4 carbon atoms or a cycloalkyl group having 3 or 4 carbon atoms,R.sub.3 is a hydrogen atom or represents 1-3 substituents which are selected from the group consisting of halogen, and alkyl, alkoxy, haloalkyl and haloalkoxy having 1-4 carbon atoms,R.sub.4 and R.sub.5 are both fluorine atoms, or whereinR.sub.4 is a chlorine atom and R.sub.5 is a hydrogen atom, andX is an oxygen or sulphur atom.The composition may be used in a dosage of 10 to 5000 g of active substance per hectare.The invention further relates to pharmaceutical compositions comprising the above compounds. Finally the invention relates to new benzoylurea compounds and to the preparation thereof.

摘要翻译： 本发明涉及对螨虫，粉虱和蓟马有活性的组合物，其除液体或固体惰性载体材料之外还包含通式为“IMAGE”的苯甲酰脲化合物，其中R 1是氢原子或表示1或2个取代基， 选自氯，甲基和三氟甲基，R2是具有2-4个碳原子的烷基或具有3或4个碳原子的环烷基，R3是氢原子或表示1-3个选自 卤素和具有1-4个碳原子的烷基，烷氧基，卤代烷基和卤代烷氧基，R4和R5都是氟原子，或者其中R4是氯原子，R5是氢原子，X是氧或硫 原子。 组合物可以以每公顷10-5000克活性物质的剂量使用。 本发明还涉及包含上述化合物的药物组合物。 最后，本发明涉及新的苯甲酰脲化合物及其制备方法。

公开(公告)号：US4550202A

公开(公告)日：1985-10-29

申请号：US572145

申请日：1984-01-19

申请人： Marius S. Brouwer ,  Arnoldus C. Grosscurt

发明人： Marius S. Brouwer ,  Arnoldus C. Grosscurt

IPC分类号： A61K31/17 ,  A01N47/34 ,  A01P7/02 ,  C07C67/00 ,  C07C239/00 ,  C07C251/50 ,  C07C275/54 ,  C07C325/00 ,  C07C335/26 ,  C07D213/53 ,  C07C157/12 ,  C07C127/22

CPC分类号： C07D213/53 ,  A01N47/34 ,  C07C275/54

摘要： The invention relates to new benzoylurea compounds of the general formula ##STR1## wherein R.sub.1 is a halogen atom,R.sub.2 is a hydrogen atom or a halogen atom,R.sub.3 is a hydrogen atom or represents 1 or 2 substituents which are selected from the group consisting of chlorine, methyl and trifluoromethyl,R.sub.4 is a hydrogen atom, an alkyl group having 1-6 carbon atoms or a cycloalkyl group having 3-6 carbon atoms,R.sub.5 is a hydrogen atom or an alkyl group having 1-4 carbon atoms, andA is a phenyl group or a heteroaryl group having 1 or 2 nitrogen atoms, which groups may be substituted with 1-3 substituents which are selected from the group consisting of halogen, and alkyl, alkoxy, haloalkyl and haloalkoxy having 1-4 carbon atoms.The compounds have an insecticidal and acaricidal activity. After having been processed to compositions, the compounds may be used for control of insects and/or mites in a dosage from 1 to 5000 g of active substance per hectare. In addition the compounds have an anti-tumor activity and may be used in pharmaceutical compositions.

摘要翻译： 本发明涉及通式为“IMAGE”的新的苯甲酰脲化合物，其中R 1为卤素原子，R 2为氢原子或卤素原子，R 3为氢原子或表示1或2个选自以下的取代基： 氯，甲基和三氟甲基，R4是氢原子，具有1-6个碳原子的烷基或具有3-6个碳原子的环烷基，R5是氢原子或具有1-4个碳原子的烷基，A 是具有1或2个氮原子的苯基或杂芳基，该基团可以被选自卤素和具有1-4个碳原子的烷基，烷氧基，卤代烷基和卤代烷氧基的1-3个取代基取代。 这些化合物具有杀虫和杀螨活性。 经处理成组合物后，化合物可用于以每公顷1至5000克活性物质的剂量控制昆虫和/或螨虫。 此外，化合物具有抗肿瘤活性并可用于药物组合物。