公开(公告)号：US07560479B2

公开(公告)日：2009-07-14

申请号：US10552502

申请日：2003-04-10

申请人： Anita Mehta ,  Bruhaspathy Miriyala ,  Arundutt Viswanatham Silamkoti ,  Jang Bahadar Gupta

发明人： Anita Mehta ,  Bruhaspathy Miriyala ,  Arundutt Viswanatham Silamkoti ,  Jang Bahadar Gupta

IPC分类号： A61K31/403 ,  C07D209/52

CPC分类号： C07D209/52

摘要： This invention relates to derivatives of 3,6-disubstituted azabicyclo hexanes. The compounds of this invention can function as muscarinic receptor antagonists and can be used for the treatment of various diseases of the respiratory, urinary and gastrointestinal systems mediated through muscarinic receptors.

摘要翻译： 本发明涉及3,6-二取代的氮杂双环己烷的衍生物。 本发明的化合物可用作毒蕈碱受体拮抗剂，可用于治疗通过毒蕈碱受体介导的呼吸，泌尿和胃肠系统的各种疾病。

公开(公告)号：US07592359B2

公开(公告)日：2009-09-22

申请号：US10552617

申请日：2003-04-10

申请人： Anita Mehta ,  Arundutt Viswanatham Silamkoti ,  Jang Bahadur Gupta

发明人： Anita Mehta ,  Arundutt Viswanatham Silamkoti ,  Jang Bahadur Gupta

IPC分类号： A61K31/445 ,  A61P11/00 ,  A61P13/00 ,  C07D211/22

CPC分类号： C07D209/52 ,  C07D405/06

摘要： This invention generally relates to derivatives of substituted azabicyclo hexanes. The compounds of this invention can function as muscarinic receptor antagonists, and can be used for the treatment of various diseases of the respiratory, urinary and gastrointestinal systems mediated through muscarinic receptors. The invention also relates to a process for the preparation of the compounds of the present invention, pharmaceutical compositions containing the compounds of the present invention and the methods of treating the diseases mediated through muscarinic receptors.

摘要翻译： 本发明一般涉及取代的氮杂双环己烷的衍生物。 本发明化合物可用作毒蕈碱受体拮抗剂，可用于治疗通过毒蕈碱受体介导的呼吸道，尿路和胃肠道系统的各种疾病。 本发明还涉及制备本发明化合物的方法，含有本发明化合物的药物组合物和通过毒蕈碱受体介导的疾病的治疗方法。

公开(公告)号：US07232835B2

公开(公告)日：2007-06-19

申请号：US10537851

申请日：2002-12-10

申请人： Anita Mehta ,  Arundutt Viswanatham Silamkoti ,  Bruhaspathy Miriyala ,  Sudershan Kumar Arora ,  Boju Srinivasulu ,  Bireshwar Mukherjee ,  Jang Bahadur Gupta

发明人： Anita Mehta ,  Arundutt Viswanatham Silamkoti ,  Bruhaspathy Miriyala ,  Sudershan Kumar Arora ,  Boju Srinivasulu ,  Bireshwar Mukherjee ,  Jang Bahadur Gupta

IPC分类号： A01N43/40 ,  A01N43/00 ,  A61K31/445 ,  A61K31/55 ,  C07D221/02

CPC分类号： C07D401/06 ,  C07D209/52 ,  C07D405/06 ,  C07D405/12 ,  C07D405/14 ,  C07D409/14

摘要： This invention relates to derivatives of 3,6-disubstituted azabicyclo compounds. The compounds of this invention can function as muscarinic receptor antagonists, and can be used for the treatment of various diseases of the respiratory, urinary and gastrointestinal systems mediated through muscarinic receptors. The invention also relates to pharmaceutical compositions containing the compounds of the present invention and the methods for treating the diseases mediated through muscarinic receptors.

摘要翻译： 本发明涉及3,6-二取代的氮杂二环化合物的衍生物。 本发明化合物可用作毒蕈碱受体拮抗剂，可用于治疗通过毒蕈碱受体介导的呼吸道，尿路和胃肠道系统的各种疾病。 本发明还涉及含有本发明化合物的药物组合物和通过毒蕈碱受体介导的疾病的治疗方法。