公开(公告)号：US07498352B2

公开(公告)日：2009-03-03

申请号：US10480849

申请日：2002-06-25

申请人： Yasuo Sugiyama ,  Masatoshi Hazama ,  Asae Shintani

发明人： Yasuo Sugiyama ,  Masatoshi Hazama ,  Asae Shintani

IPC分类号： A61K31/42 ,  C07D263/30

CPC分类号： A61K31/422

摘要： The present invention provides a TGF-β superfamily production/secretion promoter comprising a compound represented by the formula wherein R1 is a halogen atom, an optionally substituted heterocyclic group, an optionally substituted hydroxy group, an optionally substituted thiol group or an optionally substituted amino group; A is an optionally substituted acyl group, an optionally substituted heterocyclic group, an optionally substituted hydroxy group or an optionally esterified or amidated carboxyl group; B is an optionally substituted aromatic group; X is an oxygen atom, a sulfur atom or an optionally substituted nitrogen atom; and Y is a divalent hydrocarbon group or heterocyclic group, or a salt thereof or a prodrug thereof, which is useful as an agent for the prophylaxis or treatment of dysautonomia, bladder dysfunction, hearing impairment, bone disease and the like.

摘要翻译： 本发明提供了包含下式表示的化合物的TGF-β超家族产生/分泌促进剂，其中R1是卤素原子，任选取代的杂环基，任选取代的羟基，任选取代的硫醇基或任选取代的氨基 ; A是任选取代的酰基，任选取代的杂环基，任选取代的羟基或任选酯化或酰胺化的羧基; B是任选取代的芳基; X是氧原子，硫原子或任选取代的氮原子; Y是二价烃基或杂环基，或其盐或其前药，其可用作预防或治疗自主神经功能障碍，膀胱功能障碍，听力障碍，骨病等。