摘要:
The present invention provides an agent for preventing or treating organ functional disorders, an agent for preventing or treating organ dysfunction and an agent for preventing or treating obesity and deuteropathy thereof, each of which comprises a compound having an effect of increasing ubiquinone or a salt thereof or a prodrug thereof; as well as a ubiquinone increasing agent comprising a compound having a squalene synthase inhibitory effect or a salt thereof or a prodrug thereof.
摘要:
1,3-Azole derivatives, pharmaceutical compositions thereof and methods for regulating the function of retinoid-related receptors with 1,3-azole derivatives are disclosed. Such regulation may be useful for preventing or treating diabetes, preventing or treating hyperlipidemia, preventing or treating impaired glucose tolerance (IGT) or for preventing transition from impaired glucose tolerance to diabetes.
摘要:
This invention provides new benzoxazepine compounds represented by the formula: ##STR1## [wherein R stands for a lower alkyl group optionally substituted with a hydroxyl group, X stands for an optionally substituted carbamoyl group or an optionally substituted heterocyclic group having a deprotonatable hydrogen atom, R.sub.1 stands for a lower alkyl group and W stands for a halogen atom] having activities of lowering chlesterol-level and lowering trigluceride-level, and being useful for prophylaxis and therapy of hyperlipidemia.
摘要:
An electric heating unit comprises a heat-insulating main body consisting primarily of a heat-insulating material and formed with a groove in a surface thereof, and a heating element provided in the groove and shaped in the form of waves with an amplitude greater than the width of the groove, the heating element having at widthwise opposite sides thereof bent portions extending into the main body from groove-defining opposite side walls thereof and thereby integrally supported by the main body. A bottom-forming member of refractory material made separately from the main body covers the bottom of the groove and is supported by the main body integrally therewith so that the surface of the member toward the opening of the groove is exposed from the main body. The heating element is disposed closer to the groove opening than the bottom-forming member and integrally supported by the main body so as to be in contact with portions of the surface of the member. The heating element is positioned within the groove and exposed outside the main body.
摘要:
A vertical spindle duplex head for a grinder includes an annular pressure wheel and a receiver wheel arranged to rotate and revolve workpieces between the annular surfaces of the pressure wheel and the receiver wheel and a grindstone for one end portion of the workpieces driven in the opposite directions of rotation of the pressure wheel and receiver wheel and at their different rotational ratios. The workpieces rotate and revolve between these wheels, thereby grinding their end face by means of a grindstone arranged around the external periphery of a rotary carrier.The pressure wheel and receiver wheel are rotatably driven in opposite directions and at their different rotational speeds by distributing driving force from one source to each of them and a variable driving means is provided on one of the transmittance routes of the driving force extending from the place of distributing the driving force to both of the pressure wheel and the receiver wheel, whereby the rotational ratio of each of them can be optionally changed.
摘要:
This invention provides new benzoxazepine compounds represented by the formula: [wherein R stands for a lower alkyl group optionally substituted with a hydroxyl group, X stands for an optionally substituted carbamoyl group or an optionally substituted heterocyclic group having a deprotonatable hydrogen atom, R1 stands for a lower alkyl group and W stands for a halogen atom] having activities of lowering cholesterol-level and lowering triglyceride-level, and being useful for prophylaxis and therapy of hyperlipidemia.
摘要:
The present invention provides a non-human mammal, or a part of its living body, which stably retains a DNA encoding a heterologous PPARα in an expressible state, and has one or more different genetic modifications resulting in a pathological condition identical or similar to a disease associated with the regulation of PPARα activity or a foreign DNA under the control of a promoter having PPRE, as well as a method of screening for agonists/antagonists for the heterologous PPARα using the animal.
摘要:
This invention provides new condensed furan compounds which exhibit excellent 2,3-oxidosqualene cyclase inhibition and high-density lipoprotein-cholesterol elevating activities.This invention also provides a therapeutic and prophylactic agent for hyperlipidemia, hypercholesterolemia and atherosclerosis.
摘要:
N-containing, condensed heterocyclic compounds and salts thereof are disclosed which are useful for inhibiting squalene synthetase and fungal growth, and which are useful for treating or preventing hyperlipidemia. Also disclosed is a method for producing these compounds.
摘要:
A decoder for decoding a code C which is two-stage encoded by a C.sub.1 code ((N, K, D) Q dimensional code) and a C.sub.2 code ((n, k, d) q dimensional code), which includes: a C.sub.1 decoder including an error correction means for conducting an error correction of the errors below the number [(D-1)/2] to output the decoded word, and a weight generator which generates wj (j=1, 2, . . . , n) when i (i=0 to [(D-1)/2 ]) errors are corrected and an error detection (correction disability) is judged; a C.sub.2 decoder for decoding the C.sub.2 code including a forfeiture error correction means for judging the position j of the wj among the weight vector w in the received word r which is obtained in accordance with the decoded word output from the C.sub.1 decoder, and conducting a forfeiture error decoding. A weighted distance calculating means for calculating the weighted distance .rho..sup.(k) between the decoded word r.sup.(k) and the received word r when a decoded word in each of K=0, 1, . . . , [(D-1)/2] is obtained; the C.sub.2 decoder also including a comparator for comparing the weighted distance .rho..sup.(k) and the integer .tau., outputs the decoded word r.sup.(k) as a correct decoded word when the .rho..sup.(k) is smaller than or equal to .tau., and the correction disability signal when the .rho..sup.(k) is larger than .tau. or no decoded word is obtained by the forfeiture error correction means.