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公开(公告)号：US12102087B2
公开(公告)日：2024-10-01
申请号：US17363334
申请日：2021-06-30
IPC分类号： A01N43/80 , A01N25/00 , A01N37/34 , A01N43/38 , A01N43/40 , A01N43/54 , A01N43/56 , A01N43/90 , A01N47/08 , A01N47/28 , A01N57/12
CPC分类号： A01N43/80 , A01N25/00 , A01N37/34 , A01N43/38 , A01N43/40 , A01N43/54 , A01N43/56 , A01N43/90 , A01N47/08 , A01N47/28 , A01N57/12 , A01N43/80 , A01N37/34 , A01N37/38 , A01N37/46 , A01N37/50 , A01N43/40 , A01N43/50 , A01N43/54 , A01N43/56 , A01N43/653 , A01N43/88 , A01N43/90 , A01N45/02 , A01N47/04 , A01N47/12 , A01N47/14 , A01N47/24 , A01N47/34 , A01N57/12 , A01N59/02 , A01N59/20 , A01N59/26 , A01N43/80 , A01N37/20 , A01N37/42 , A01N25/00 , A01N37/20 , A01N37/42 , A01N43/40 , A01N43/50 , A01N43/80 , A01N47/12
摘要： The present invention relates to active compound combinations, in particular within a fungicide composition, which comprises (A) a thiazolylisoxazoline of formula (I) and a further fungicidally active compound (B). Moreover, the invention relates to a method for curatively or preventively controlling the phytopathogenic fungi of plants or crops, to the use of a combination according to the invention for the treatment of seed, to a method for protecting a seed and not at least to the treated seed.
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公开(公告)号：US11371057B2
公开(公告)日：2022-06-28
申请号：US16704487
申请日：2019-12-05
发明人： Ruediger Hain , Gerhard Johann , Guenter Donn
IPC分类号： C12N15/82 , A01N25/00 , A01N43/50 , A01N43/54 , A01N43/653 , A01N43/66 , A01N43/88 , A01N43/90
摘要： Present invention relates to the use of the ALS inhibitor herbicides for controlling unwanted vegetation in ALS inhibitor herbicide tolerant Beta vulgaris plants, more especially, present invention relates to the use of ALS inhibitor herbicides for control of unwanted vegetation in Beta vulgaris, preferably in sugar beet growing areas in which the Beta vulgaris, preferably sugar beet comprise a mutation in codon 1705-1707 of an endogenous ALS gene encoding an ALS protein containing an amino acid that is different from tryptophan at position 569, preferably the tryptophan is substituted by leucine.
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公开(公告)号：US20220153745A1
公开(公告)日：2022-05-19
申请号：US17516542
申请日：2021-11-01
发明人： Dirk BROHM , Melanie HEROULT , Marie-Pierre COLLIN , Walter HÜBSCH , Mario LOBELL , Klemens LUSTIG , Sylvia GRÜNEWALD , Ulf BÖMER , Verena VÖHRINGER
IPC分类号： C07D487/04 , C07D409/14 , C07D409/04 , A61P35/00 , A61K31/53 , A61K31/5355 , A61K31/5377 , A61K31/541
摘要： This invention relates to novel substituted 5-(1-benzothiophen-2-yl) pyrrolo[2,1-f][1,2,4]triazin-4-amine derivatives of formula (I) wherein R1 is hydrogen, chloro, methyl or methoxy, R2 is hydrogen or methoxy, with the proviso that at least one of R1 and R2 is other than hydrogen, G1 represents chloro, (C1-C4)-alkyl, (C1-C4)-alkoxycarbonyl, 5-membered aza-heteroaryl, or the group —CH2—OR3, —CH2—NR4R5 or —C(=0)-NR4R6, and G2 represents chloro, cyano, (C1-C4)-alkyl, or the group —CR8AR8B—OH, —CH2—NR9R10, —C(=0)—NR11R12 or —CH2—OR15, having protein tyrosine kinase inhibitory activities, to processes for the preparation of such compounds, to pharmaceutical compositions containing such compounds, and to the use of such compounds or compositions for treating proliferative disorders, in particular cancer and tumor diseases.
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公开(公告)号：US11202447B2
公开(公告)日：2021-12-21
申请号：US13965855
申请日：2013-08-13
IPC分类号： A01N43/653 , A01N47/38 , A01N43/56
摘要： The invention relates to herbicidal compositions comprising an effective amount of an active ingredient combination composed of (a) at least one substituted thien-3-ylsulfonylamino(thio)carbonyl-triazolin(thi) one of the formula (I) in which R1, R2 and R3 are as defined in the description, —or salts of the compounds of the formula (I)— and (b) one or more compounds from a second group of herbicides which comprises selected 4-HPPD inhibitors, and, if desired, additionally (c) a crop plant tolerance promoter compound. The invention further relates to the use of the compositions for controlling unwanted plant growth and to a process for producing the compositions.
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公开(公告)号：US11147274B2
公开(公告)日：2021-10-19
申请号：US16369725
申请日：2019-03-29
IPC分类号： A01N43/80 , A01N47/12 , A01N59/26 , A01N25/00 , A01N37/34 , A01N43/38 , A01N43/40 , A01N43/54 , A01N43/56 , A01N43/90 , A01N47/08 , A01N47/28 , A01N57/12
摘要： The present invention relates to active compound combinations, in particular within a fungicide composition, which comprises (A) a thiazolylisoxazoline of formula (I) and a further fungicidally active compound (B). Moreover, the invention relates to a method for curatively or preventively controlling the phytopathogenic fungi of plants or crops, to the use of a combination according to the invention for the treatment of seed, to a method for protecting a seed and not at least to the treated seed.
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公开(公告)号：US10463666B2
公开(公告)日：2019-11-05
申请号：US14965173
申请日：2015-12-10
IPC分类号： A61K31/519 , A61K31/4415 , A61K31/525 , A61K31/56 , A61K31/565 , A61K31/57 , A61K31/585 , A61K45/06 , A61K31/567
摘要： The present invention relates to a pharmaceutical composition which comprises progestogens, preferably drospirenone, estrogens, preferably ethinylestradiol and 5-methyl-(6S)-tetrahydrofolate, can be employed as oral contraceptive and moreover prevents disorders caused by folate deficiency in the consumers, in particular cardiovascular disorders and, after conception of the embryo, congenital malformations caused by folate deficiency such as, for example, neural tube defects, ventricular valve defects, urogenital defects, and cleft lip, jaw and palate, without masking the symptoms of vitamin B12 deficiency, and at the same time even in the case of homozygous or heterozygous polymorphism of methylenetetrahydrofolate reductase facilitates unimpaired utilizability of the folate component 5-methyl-(6S)-tetrahydrofolate by the body and thus its biological activity for preventing the abovementioned congenital malformations caused by folate deficiency. In addition, a prolonged protective effect is maintained after discontinuation of the contraceptive.
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公开(公告)号：US10414762B2
公开(公告)日：2019-09-17
申请号：US15884159
申请日：2018-01-30
发明人： Joachim Luithle , Frank-Gerhard Böβ , Christina Erb , Katrin Schnizler , Timo Flessner , Marja van Kampen , Christoph Methfessel
IPC分类号： A61K31/439 , C07D453/02 , C07D453/04
摘要： The invention relates to novel amides of acetic and propionic acids, methods for production and use thereof for the production of medicaments for the treatment and/or prophylaxis of diseases and for improving perception, concentration, learning ability and memory.
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公开(公告)号：US20190233369A1
公开(公告)日：2019-08-01
申请号：US16378823
申请日：2019-04-09
发明人： Erwin HACKER , Georg BONFIG-PICARD , Stefan LEHR , Udo BICKERS , Martin HESS , Klaus TRABOLD , Mathias SCHMIDT , Frank ZIEMER , Juan Pedro RUIZ-SANTAELLA MORENO
IPC分类号： C07C311/38 , A01N43/653 , C07D405/06 , A01N25/00 , A01N39/04 , A01N41/06
CPC分类号： C07C311/38 , A01N25/00 , A01N39/04 , A01N41/06 , A01N43/653 , C07D405/06 , Y02A40/143 , A01N37/50 , A01N2300/00
摘要： Compounds (A) can be used for increasing the yield of useful plants or crop plants with respect to their harvested plant organs, wherein the Compound (A) is selected from compounds of the formula (I) or salts thereof, wherein the symbols are defined as in claim 1, preferably cyprosulfamide [Compound (A1)].
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公开(公告)号：US20190077765A1
公开(公告)日：2019-03-14
申请号：US16190688
申请日：2018-11-14
发明人： Erwin Hacker , Stefan Lehr , Georg Bonfig-Picard , Martin Hess , Frank Ziemer , Mathias Schmidt , Martin Jeffrey Hills , Udo Bickers , Juan Pedro Ruiz-Santaella Moreno
IPC分类号： C07D231/06 , A01N39/04 , A01N43/56 , A01N43/653
摘要： Compounds (A) can be used for increasing the yield of useful plants or crop plants with respect to their harvested plant organs, wherein the Compound (A) is selected from compounds of the formula (I) or salts thereof, in which (R1)n is n radicals R1 where the R1 are identical or different and are each halogen or (C1-C4)-haloalkyl, n is an integer from 1 to 3, R2 is hydrogen, (C1-C6)-alkyl, (C1-C4)-alkoxy-(C1-C4)-alkyl, (C3-C6)-cycloalkyl, tri-(C1-C4)-alkyl-silyl or tri-(C1-C4)-alkyl-silylmethyl, R3 is hydrogen, (C1-C6)-alkyl, (C1-C6)-haloalkyl, (C2-C6)-alkenyl, (C2-C6)-alkynyl or (C3-C6)-cycloalkyl, and R4 is hydrogen or (C1-C12)-alkyl, preferably mefepyr-diethyl (Compound (A1)]
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公开(公告)号：US20190040057A1
公开(公告)日：2019-02-07
申请号：US15907040
申请日：2018-02-27
发明人： Martin HENDRIX , Frank-Gerhard BÖß , Christina ERB , Joachim KRÜGER , Christoph METHFESSEL , Rudy SCHREIBER , Welf-Burkhard WIESE , Joachim LUITHLE
IPC分类号： C07D453/02
摘要： The invention relates to novel heteroaryl carboxamides, processes for their preparation, and their use for producing medicaments for the treatment and/or prophylaxis of diseases and for improving perception, concentration, learning and/or memory.
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