-
公开(公告)号：US20220153745A1
公开(公告)日：2022-05-19
申请号：US17516542
申请日：2021-11-01
发明人： Dirk BROHM , Melanie HEROULT , Marie-Pierre COLLIN , Walter HÜBSCH , Mario LOBELL , Klemens LUSTIG , Sylvia GRÜNEWALD , Ulf BÖMER , Verena VÖHRINGER
IPC分类号： C07D487/04 , C07D409/14 , C07D409/04 , A61P35/00 , A61K31/53 , A61K31/5355 , A61K31/5377 , A61K31/541
摘要： This invention relates to novel substituted 5-(1-benzothiophen-2-yl) pyrrolo[2,1-f][1,2,4]triazin-4-amine derivatives of formula (I) wherein R1 is hydrogen, chloro, methyl or methoxy, R2 is hydrogen or methoxy, with the proviso that at least one of R1 and R2 is other than hydrogen, G1 represents chloro, (C1-C4)-alkyl, (C1-C4)-alkoxycarbonyl, 5-membered aza-heteroaryl, or the group —CH2—OR3, —CH2—NR4R5 or —C(=0)-NR4R6, and G2 represents chloro, cyano, (C1-C4)-alkyl, or the group —CR8AR8B—OH, —CH2—NR9R10, —C(=0)—NR11R12 or —CH2—OR15, having protein tyrosine kinase inhibitory activities, to processes for the preparation of such compounds, to pharmaceutical compositions containing such compounds, and to the use of such compounds or compositions for treating proliferative disorders, in particular cancer and tumor diseases.
-
公开(公告)号：US20190016724A1
公开(公告)日：2019-01-17
申请号：US15900725
申请日：2018-02-20
发明人： Dirk BROHM , Melanie HEROULT , Marie-Pierre COLLIN , Walter HÜBSCH , Mario LOBELL , Klemens LUSTIG , Sylvia GRÜNEWALD , Ulf BÖMER , Verena VÖHRINGER
IPC分类号： C07D487/04 , A61K31/541 , A61K31/5377 , A61K31/53 , A61K31/5355
摘要： This invention relates to novel substituted 5-(1-benzothiophen-2-yl) pyrrolo[2,1-f][1,2,4]triazin-4-amine derivatives of formula (I) wherein R1 is hydrogen, chloro, methyl or methoxy, R2 is hydrogen or methoxy, with the proviso that at least one of R1 and R2 is other than hydrogen, G1 represents chloro, (C1-C4)-alkyl, (C1-C4)-alkoxycarbonyl, 5-membered aza-heteroaryl, or the group —CH2—OR3, —CH2—NR4R5 or —C(═O)-NR4R6, and G2 represents chloro, cyano, (C1-C4)-alkyl, or the group —CR8AR8B—OH, —CH2—NR9R10, —C(═O)—NR11R12 or —CH2—OR15, having protein tyrosine kinase inhibitory activities, to processes for the preparation of such compounds, to pharmaceutical compositions containing such compounds, and to the use of such compounds or compositions for treating proliferative disorders, in particular cancer and tumor diseases.
-
公开(公告)号：US20150274754A1
公开(公告)日：2015-10-01
申请号：US14738148
申请日：2015-06-12
发明人： Markus FOLLMANN , Johannes-Peter STASCH , Gorden REDLICH , Nils GRIEBENOW , Dieter LANG , Frank WUNDER , Walter HÜBSCH , Alexandros VAKALOPOULOS , Adrian TERSTEEGEN
IPC分类号： C07D519/00 , A61K31/53 , A61K45/06 , A61K31/519
CPC分类号： C07D519/00 , A61K31/519 , A61K31/53 , A61K45/06 , C07D471/04
摘要： The present application relates to novel substituted fused pyrimidines and triazines, to processes for their preparation, to their use alone or in combinations for the treatment and/or prophylaxis of diseases, and to their use for producing medicaments for the treatment and/or prophylaxis of diseases, in particular for the treatment and/or prophylaxis of cardiovascular disorders.
摘要翻译： 本申请涉及新颖的取代的稠合嘧啶和三嗪，其制备方法，单独使用或组合用于治疗和/或预防疾病及其用于生产药物用于治疗和/或预防 疾病，特别是用于治疗和/或预防心血管疾病。
-
公开(公告)号：US20140162981A1
公开(公告)日：2014-06-12
申请号：US13893344
申请日：2013-05-14
发明人： Peter NELL , Walter HÜBSCH , Barbara ALBRECHT-KÜPPER , Jorg KELDENICH , Alexandros VAKALOPOULOS , Frank SÜSSMEIER , Katja ZIMMERMANN , Dieter LANG , Daniel MEIBOM
IPC分类号： C07D413/14 , C07D413/12 , C07F7/10 , A61K31/695 , A61K31/4439 , A61K45/06
CPC分类号： A61K31/4439 , A61K31/695 , A61K45/06 , C07D413/12 , C07D413/14 , C07D419/14 , C07F7/10
摘要： The present application relates to novel substituted aryloxazole derivatives, to processes for their preparation, to their use for the treatment and/or prophylaxis of diseases and to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, preferably for the treatment and/or prevention of cardiovascular and metabolic disorders.
摘要翻译： 本申请涉及新型取代的芳氧唑衍生物，其制备方法，其用于治疗和/或预防疾病的用途及其用于制备用于治疗和/或预防疾病的药物的用途，优选用于治疗和/ /或预防心血管和代谢紊乱。
-
公开(公告)号：US20150105374A1
公开(公告)日：2015-04-16
申请号：US14491558
申请日：2014-09-19
发明人： Markus FOLLMANN , Johannes-Peter STASCH , Gorden REDLICH , Nils GRIEBENOW , Dieter LANG , Frank WUNDER , Walter HÜBSCH , Niels LINDNER , Alexandros VAKALOPOULOS , Adrian TERSTEEGEN
IPC分类号： A61K31/519 , A61K45/06 , A61K31/527 , A61K31/5377 , A61K31/5386 , A61K31/541 , C07D519/00 , C07D487/04
CPC分类号： A61K31/519 , A61K31/527 , A61K31/5377 , A61K31/5383 , A61K31/5386 , A61K31/541 , A61K45/06 , C07D471/04 , C07D487/04 , C07D491/20 , C07D498/08 , C07D519/00
摘要： The present application relates to novel substituted annellated pyrimidines, methods for production thereof, use thereof alone or in combinations for treating and/or preventing diseases and use thereof for the production of medicinal products for treating and/or preventing diseases, in particular for treating and/or preventing cardiovascular diseases.
摘要翻译： 本申请涉及新颖的取代的环状嘧啶，其制备方法，单独使用或组合用于治疗和/或预防疾病及其用于生产用于治疗和/或预防疾病的药物的用途，特别是用于治疗和/ /或预防心血管疾病。
-
公开(公告)号：US20140296295A1
公开(公告)日：2014-10-02
申请号：US14304801
申请日：2014-06-13
发明人： Walter HÜBSCH , Daniel MEIBOM , Alexandros VAKALOPOULOS , Barbara ALBRECHT-KÜPPER , Peter NELL , Katja ZIMMERMANN , Frank SÜßMEIER , Joerg KELDENICH
IPC分类号： C07D417/14 , A61K31/4439 , A61K31/44 , A61K45/06 , C07D413/12 , C07D401/12 , C07D213/85 , A61K31/444 , C07D417/12
CPC分类号： A61K31/44 , A61K31/4439 , A61K31/444 , A61K45/06 , C07D213/70 , C07D213/85 , C07D401/12 , C07D413/12 , C07D417/12 , C07D417/14
摘要： The present application relates to novel 2-alkoxy-substituted dicyanopyridines, to processes for their preparation, to their use for the treatment and/or prophylaxis of diseases and to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, preferably for the treatment and/or prevention of cardiovascular disorders.
摘要翻译： 本申请涉及新的2-烷氧基取代的二氰基吡啶，其制备方法，其用于治疗和/或预防疾病的用途及其用于制备用于治疗和/或预防疾病的药物的用途，优选用于 治疗和/或预防心血管疾病。
-
公开(公告)号：US20130158000A1
公开(公告)日：2013-06-20
申请号：US13715553
申请日：2012-12-14
发明人： Dirk BROHM , Melanie HEROULT , Marie-Pierre COLLIN , Walter HÜBSCH , Mario LOBELL , Klemens LUSTIG , Sylvia GRÜNEWALD , Ulf BÖMER
IPC分类号： C07D487/04
CPC分类号： C07D487/04 , A61K31/53 , A61K31/5355 , A61K31/5377 , A61K31/541
摘要： This invention relates to novel substituted 5-(1-benzothiophen-2-yl)pyrrolo[2,1-f][1,2,4]triazin-4-amine derivatives having protein tyrosine kinase inhibitory activities, to processes for the preparation of such compounds, to pharmaceutical compositions containing such compounds, and to the use of such compounds or compositions for treating proliferative disorders, in particular cancer and tumor diseases.
-
公开(公告)号：US20170233413A1
公开(公告)日：2017-08-17
申请号：US15503448
申请日：2015-08-25
发明人： Walter HÜBSCH , Alexandros VAKALOPOULOS , Markus FOLLMANN , Gaelle VALOT , Johannes-Peter STASCH , Damian BROCKSCHNIEDER , Tobias MARQUARDT , Frank WUNDER , Adrian TERSTEEGEN , Lisa DIETZ , Dieter LANG , Niels LINDNER
IPC分类号： C07D519/00 , C07D487/04 , A61K9/08 , A61K31/519 , A61K9/20 , A61K9/00
CPC分类号： C07D519/00 , A61K9/0053 , A61K9/08 , A61K9/20 , A61K31/519 , C07D471/04 , C07D487/04
摘要： The present application relates to novel substituted fused pyrimidines, to processes for their preparation, to their use alone or in combinations for the treatment and/or prophylaxis of diseases, and to their use for producing medicaments for the treatment and/or prophylaxis of diseases, in particular for the treatment and/or prophylaxis of cardiovascular disorders.
-
公开(公告)号：US20140031391A1
公开(公告)日：2014-01-30
申请号：US13945675
申请日：2013-07-18
发明人： Michael HAHN , Markus FOLLMANN , Walter HÜBSCH , Eva-Maria BECKER , Johannes-Peter STASCH , Joerg KELDENICH , Martina DELBECK , Hanna TINEL , Frank WUNDER , Joachim MITTENDORF , Ildiko TEREBESI , Dieter LANG , René MARTIN
IPC分类号： C07D215/48 , C07D401/12 , A61K45/06 , A61K31/4706 , A61K31/4709 , C07D413/12
CPC分类号： C07D215/48 , A61K31/47 , A61K31/4706 , A61K31/4709 , A61K45/06 , C07D217/26 , C07D401/12 , C07D413/12
摘要： The present application relates to novel 5-amino-5,6,7,8-tetrahydroquinoline-2-carboxylic acids, to processes for their preparation, to their use for the treatment and/or prevention of diseases, and to their use for producing medicaments for the treatment and/or prevention of diseases, especially for the treatment and/or prevention of cardiovascular and cardiopulmonary disorders.
摘要翻译： 本申请涉及新的5-氨基-5,6,7,8-四氢喹啉-2-羧酸，其制备方法，其用于治疗和/或预防疾病的用途及其用于生产 用于治疗和/或预防疾病的药物，特别是用于治疗和/或预防心血管和心肺疾病的药物。
-
-
-
-
-
-
-
-
搜索结果
9 条记录 (耗时 0.035 秒)
