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公开(公告)号：US10338060B2
公开(公告)日：2019-07-02
申请号：US16180666
申请日：2018-11-05
Applicant: BioCrine AB
Inventor： Per-Olof Berggren
Abstract: The present invention provides method for monitoring physiological status of an organ in a subject by monitoring morphological changes over time in transplanted tissue on an eye of the subject.
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公开(公告)号：US20190072542A1
公开(公告)日：2019-03-07
申请号：US16180666
申请日：2018-11-05
Applicant: BioCrine AB
Inventor： Per-Olof Berggren
CPC classification number: G01N33/5026 , A61B3/10 , A61B3/13 , A61B5/0068 , A61B5/0071 , A61B5/4227 , A61B5/425 , A61B5/4842 , A61B5/4848 , A61K49/0004 , A61K49/0008 , A61K49/0041 , A61K49/0054 , A61K49/0097 , G01N33/5088 , G01N2800/042
Abstract: The present invention provides method for monitoring physiological status of an organ in a subject by monitoring morphological changes over time in transplanted tissue on an eye of the subject.
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公开(公告)号：US09462973B2
公开(公告)日：2016-10-11
申请号：US13950710
申请日：2013-07-25
Applicant: BioCrine AB
Inventor： Per-Olof Berggren
CPC classification number: G01N33/5026 , A61B3/10 , A61B3/13 , A61B5/0068 , A61B5/0071 , A61B5/4227 , A61B5/425 , A61B5/4842 , A61B5/4848 , A61K49/0004 , A61K49/0008 , A61K49/0041 , A61K49/0054 , A61K49/0097 , G01N33/5088 , G01N2800/042
Abstract: The present invention provides method for monitoring physiological status of an organ in a subject by monitoring morphological changes over time in transplanted tissue on an eye of the subject.
Abstract translation: 本发明提供了通过监测受试者的眼睛上的移植组织中随时间的形态学变化来监测受试者的器官的生理状态的方法。
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公开(公告)号：US20140004102A1
公开(公告)日：2014-01-02
申请号：US14026145
申请日：2013-09-13
Applicant: BIOCRINE AB
Inventor： Per Olof Berggren , Shao-Nian Yang
IPC: G01N33/50
CPC classification number: A61K39/395 , A61K31/472 , A61K31/496 , A61K31/7076 , A61K31/713 , C07K16/2842 , C12N15/113 , C12N15/1138 , C12N15/115 , C12N2310/14 , C12N2320/30 , G01N33/5041 , G01N33/507
Abstract: The present invention provides methods for identifying candidate compounds for limiting development of and/or treating diabetes, and methods for limiting development of and/or treating diabetes.
Abstract translation: 本发明提供用于鉴定用于限制糖尿病发展和/或治疗糖尿病的候选化合物的方法，以及限制糖尿病发展和/或治疗糖尿病的方法。
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公开(公告)号：US20170333555A1
公开(公告)日：2017-11-23
申请号：US15660340
申请日：2017-07-26
Applicant: Biocrine AB
Inventor： Per-Olof Berggren , Shao-Nian Yang
IPC: A61K39/395 , C12N15/113 , A61K31/496 , A61K31/7076 , A61K31/472 , C07K16/28 , A61K31/713 , G01N33/50 , C12N15/115
CPC classification number: A61K39/395 , A61K31/472 , A61K31/496 , A61K31/7076 , A61K31/713 , C07K16/2842 , C12N15/113 , C12N15/1138 , C12N15/115 , C12N2310/14 , C12N2320/30 , G01N33/5041 , G01N33/507
Abstract: The present invention provides methods for identifying candidate compounds for limiting development of and/or treating diabetes, and methods for limiting development of and/or treating diabetes.
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Patent Agency Ranking
公开(公告)号：US20170037118A1
公开(公告)日：2017-02-09
申请号：US15299540
申请日：2016-10-21
Applicant: Biocrine AB
Inventor： Per-Olof BERGGREN , Lisa JUNTTI-BERGGREN
IPC: C07K16/18 , C12N15/113 , A61K47/48
CPC classification number: C07K16/18 , A61K47/549 , A61K47/64 , C07K2319/00 , C12N15/113 , C12N2310/11 , C12N2310/14 , C12N2310/141
Abstract: Provided herein are methods and compositions for limiting development of and/or treating diabetes, involving compounds of formula A-B, wherein A is a pancreatic β cell targeting moiety, and B is an inhibitor of expression and/or activity of Apolipoprotein CIII (apoCIII), protein kinase A (PKA), Src kinase, and/or β1 integrin.
Abstract translation: 本文提供了限制糖尿病发展和/或治疗糖尿病的方法和组合物，其涉及式AB化合物，其中A是胰腺β细胞靶向部分，B是载脂蛋白CIII（apoCIII）的表达和/或活性的抑制剂， 蛋白激酶A（PKA），Src激酶和/或β1整联蛋白。
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公开(公告)号：US20170016883A1
公开(公告)日：2017-01-19
申请号：US15278933
申请日：2016-09-28
Applicant: BioCrine AB
Inventor： Per-Olof Berggren
CPC classification number: G01N33/5026 , A61B3/10 , A61B3/13 , A61B5/0068 , A61B5/0071 , A61B5/4227 , A61B5/425 , A61B5/4842 , A61B5/4848 , A61K49/0004 , A61K49/0008 , A61K49/0041 , A61K49/0054 , A61K49/0097 , G01N33/5088 , G01N2800/042
Abstract: The present invention provides method for monitoring physiological status of an organ in a subject by monitoring morphological changes over time in transplanted tissue on an eye of the subject.
Abstract translation: 本发明提供了通过监测受试者的眼睛上的移植组织中随时间的形态学变化来监测受试者的器官的生理状态的方法。
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公开(公告)号：US20160194634A1
公开(公告)日：2016-07-07
申请号：US14995645
申请日：2016-01-14
Applicant: Biocrine AB
Inventor： Per Olof Berggren , Shao-Nian Yang
IPC: C12N15/113
CPC classification number: A61K39/395 , A61K31/472 , A61K31/496 , A61K31/7076 , A61K31/713 , C07K16/2842 , C12N15/113 , C12N15/1138 , C12N15/115 , C12N2310/14 , C12N2320/30 , G01N33/5041 , G01N33/507
Abstract: The present invention provides methods for identifying candidate compounds for limiting development of and/or treating diabetes, and methods for limiting development of and/or treating diabetes.
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公开(公告)号：US20160193331A1
公开(公告)日：2016-07-07
申请号：US14995341
申请日：2016-01-14
Applicant: Biocrine AB
Inventor： Per Olof Berggren , Shao-Nian Yang
IPC: A61K39/395 , A61K31/713 , A61K31/7076
CPC classification number: A61K39/395 , A61K31/472 , A61K31/496 , A61K31/7076 , A61K31/713 , C07K16/2842 , C12N15/113 , C12N15/1138 , C12N15/115 , C12N2310/14 , C12N2320/30 , G01N33/5041 , G01N33/507
Abstract: The present invention provides methods for identifying candidate compounds for limiting development of and/or treating diabetes, and methods for limiting development of and/or treating diabetes.
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公开(公告)号：US09353183B2
公开(公告)日：2016-05-31
申请号：US14717903
申请日：2015-05-20
Applicant: Biocrine AB
Inventor： Per Olof Berggren , Shao-Nian Yang
IPC: A61K38/00 , A61K31/47 , A61K39/395 , C07K16/28 , G01N33/50 , A61K31/472 , A61K31/496 , A61K31/7076 , A61K31/713 , C12N15/113 , C12N15/115
CPC classification number: A61K39/395 , A61K31/472 , A61K31/496 , A61K31/7076 , A61K31/713 , C07K16/2842 , C12N15/113 , C12N15/1138 , C12N15/115 , C12N2310/14 , C12N2320/30 , G01N33/5041 , G01N33/507
Abstract: The present invention provides methods for identifying candidate compounds for limiting development of and/or treating diabetes, and methods for limiting development of and/or treating diabetes.
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