公开(公告)号：US08217028B2

公开(公告)日：2012-07-10

申请号：US12999091

申请日：2009-06-18

Applicant: Jose Luis Castro Pineiro ,  Xichen Lin ,  Qian Liu ,  Kevin Meng ,  Feng Ren ,  David R Vesey ,  Baowei Zhao

Inventor： Jose Luis Castro Pineiro ,  Xichen Lin ,  Qian Liu ,  Kevin Meng ,  Feng Ren ,  David R Vesey ,  Baowei Zhao

IPC: A61K31/4245 ,  A61K31/454 ,  A61K31/4545 ,  A61K31/4439 ,  A61P25/00 ,  C07D413/14 ,  C07D413/10

CPC classification number: C07D413/04 ,  C07D413/14

Abstract: The present invention relates to novel oxadiazole derivatives having pharmacological activity, processes for their preparation, pharmaceutical compositions containing them and their use in the treatment of various disorders.

Abstract translation: 本发明涉及具有药理活性的新型恶二唑衍生物，其制备方法，含有它们的药物组合物及其在治疗各种病症中的用途。

公开(公告)号：US08389508B2

公开(公告)日：2013-03-05

申请号：US13096641

申请日：2011-04-28

Applicant: Guanghui Deng ,  Xichen Lin ,  Feng Ren ,  Baowei Zhao

Inventor： Guanghui Deng ,  Xichen Lin ,  Feng Ren ,  Baowei Zhao

IPC: A61K31/433 ,  A61K31/454 ,  C07D417/04 ,  C07D413/04

CPC classification number: C07D417/10

Abstract: The present invention relates to novel compounds having pharmacological activity, processes for their preparation, pharmaceutical compositions containing them and their use in the treatment of various disorders.

Abstract translation: 本发明涉及具有药理活性的新化合物，其制备方法，含有它们的药物组合物及其在治疗各种疾病中的用途。

公开(公告)号：US20120101134A1

公开(公告)日：2012-04-26

申请号：US13379431

申请日：2010-06-24

Applicant: Guanghui Deng ,  Xichen Lin ,  Qinghua Meng ,  Feng Ren ,  Jia-Ning Xiang ,  Heng Xu ,  Haibo Zhang ,  Baowei Zhao

Inventor： Guanghui Deng ,  Xichen Lin ,  Qinghua Meng ,  Feng Ren ,  Jia-Ning Xiang ,  Heng Xu ,  Haibo Zhang ,  Baowei Zhao

IPC: A61K31/4439 ,  C07D413/04 ,  C07D271/107 ,  C07D285/12 ,  C07D285/08 ,  C07D277/30 ,  C07D417/04 ,  A61K31/4245 ,  A61K31/433 ,  A61K31/426 ,  A61P25/00 ,  A61P29/00 ,  A61P11/06 ,  A61P19/02 ,  A61P17/06 ,  A61P35/00 ,  A61P35/04 ,  A61P9/00 ,  A61P31/12 ,  A61P3/10 ,  C07D271/06

CPC classification number: C07D263/32 ,  A61K31/422 ,  A61K31/4245 ,  A61K31/427 ,  A61K31/433 ,  C07D271/06 ,  C07D271/10 ,  C07D271/107 ,  C07D277/22 ,  C07D277/28 ,  C07D277/30 ,  C07D285/08 ,  C07D285/12 ,  C07D413/04 ,  C07D413/14 ,  C07D417/04 ,  C07D417/14

Abstract: 5-membered heteroaryl derivatives of formula (I) or salts thereof, processes for their preparation, pharmaceutical compositions containing them and their uses in the treatment of various disorders mediated by S1P1 receptors are disclosed.

Abstract translation: 公开了式（I）的5元杂芳基衍生物或其盐，其制备方法，含有它们的药物组合物及其在治疗由S1P1受体介导的各种疾病中的用途。

公开(公告)号：US20110269738A1

公开(公告)日：2011-11-03

申请号：US13096641

申请日：2011-04-28

Applicant: Guanghui Deng ,  Xichen Lin ,  Feng Ren ,  Baowei Zhao

Inventor： Guanghui Deng ,  Xichen Lin ,  Feng Ren ,  Baowei Zhao

IPC: A61K31/433 ,  A61K31/454 ,  A61P25/00 ,  A61P29/00 ,  A61P11/06 ,  A61P9/00 ,  A61P17/06 ,  A61P35/00 ,  A61P35/04 ,  A61P31/12 ,  A61P3/10 ,  C07D417/10 ,  A61P19/02

CPC classification number: C07D417/10

Abstract: The present invention relates to novel compounds having pharmacological activity, processes for their preparation, pharmaceutical compositions containing them and their use in the treatment of various disorders.

Abstract translation: 本发明涉及具有药理活性的新化合物，其制备方法，含有它们的药物组合物及其在治疗各种疾病中的用途。

公开(公告)号：US20110086839A1

公开(公告)日：2011-04-14

申请号：US12999091

申请日：2009-06-18

Applicant: Jose Luis Castro Pineiro ,  Xichen Lin ,  Quan Liu ,  Kevin Meng ,  Feng Ren ,  David R. Vesey ,  Baowei Zhao

Inventor： Jose Luis Castro Pineiro ,  Xichen Lin ,  Quan Liu ,  Kevin Meng ,  Feng Ren ,  David R. Vesey ,  Baowei Zhao

IPC: A61K31/4245 ,  C07D413/10 ,  C07D413/14 ,  A61K31/454 ,  A61K31/4545 ,  A61K31/4439 ,  A61P25/00

CPC classification number: C07D413/04 ,  C07D413/14

Abstract: The present invention relates to novel oxadiazole derivatives having pharmacological activity, processes for their preparation, pharmaceutical compositions containing them and their use in the treatment of various disorders.

公开(公告)号：US20100010053A1

公开(公告)日：2010-01-14

申请号：US12486853

申请日：2009-06-18

Applicant: Jose Luis Castro Pineiro ,  Xichen Lin ,  Qian Liu ,  Kevin Meng ,  Feng Ren ,  David R. Vesey ,  Baowei Zhao

Inventor： Jose Luis Castro Pineiro ,  Xichen Lin ,  Qian Liu ,  Kevin Meng ,  Feng Ren ,  David R. Vesey ,  Baowei Zhao

IPC: A61K31/4245 ,  C07D271/06 ,  A61P37/06 ,  A61P29/00 ,  A61P35/00 ,  A61P1/00

CPC classification number: C07D413/04 ,  C07D413/14

Abstract: The present invention relates to novel oxadiazole derivatives having pharmacological activity, processes for their preparation, pharmaceutical compositions containing them and their use in the treatment of various disorders.

Abstract translation: 本发明涉及具有药理活性的新型恶二唑衍生物，其制备方法，含有它们的药物组合物及其在治疗各种病症中的用途。

公开(公告)号：US20100029729A1

公开(公告)日：2010-02-04

申请号：US12486859

申请日：2009-06-18

Applicant: Jose Luis Castro Pineiro ,  Xichen Lin ,  Qian Liu ,  Kevin Meng ,  Feng Ren ,  David R. Vesey ,  Baowei Zhao

Inventor： Jose Luis Castro Pineiro ,  Xichen Lin ,  Qian Liu ,  Kevin Meng ,  Feng Ren ,  David R. Vesey ,  Baowei Zhao

IPC: A61K31/4245 ,  C07D413/02 ,  A61P25/00

CPC classification number: C07D413/04 ,  C07D413/14

Abstract: The present invention relates to novel oxadiazole derivatives having pharmacological activity, processes for their preparation, pharmaceutical compositions containing them and their use in the treatment of various disorders.