公开(公告)号：US5409935A

公开(公告)日：1995-04-25

申请号：US909389

申请日：1992-07-09

申请人： Hans-Peter Schubert ,  John J. Grome ,  Barbara Kittner ,  Karl Rudolphi ,  Ulrich Gebert

发明人： Hans-Peter Schubert ,  John J. Grome ,  Barbara Kittner ,  Karl Rudolphi ,  Ulrich Gebert

IPC分类号： A61K31/522 ,  A61K20060101 ,  A61K31/52 ,  A61P25/00 ,  A61P25/02 ,  A61P25/28 ,  A61P39/06 ,  C07D20060101 ,  C07D473/04 ,  C07D473/06

CPC分类号： A61K31/52 ,  C07D473/06 ,  Y02P20/55

摘要： The use of xanthine derivatives for the treatment of secondary nerve cell damage and functional disorders after cranio-cerebral traumas (CCT)The use of xanthine derivatives of the formula I ##STR1## and of their physiologically tolerable salts, in which R.sup.1 is oxoalkyl, hydroxyalkyl or alkyl, R.sup.2 is hydrogen or alkyl and R.sup.3 is hydrogen, alkyl, oxoalkyl or an alkyl having up to 6 carbon atoms, whose carbon chain is interrupted by an oxygen atom, for the production of pharmaceuticals for the treatment of disorders which can occur after cranio-cerebral traumas is described.

摘要翻译： 使用黄嘌呤衍生物治疗二次神经细胞损伤和颅脑创伤后的功能障碍（CCT）使用式I（I）的黄嘌呤衍生物及其生理上可耐受的盐，其中R1是 氧代烷基，羟基烷基或烷基，R 2是氢或烷基，R 3是氢，烷基，氧代烷基或具有至多6个碳原子的烷基，其碳链被氧原子间隔，用于制备用于治疗疾病的药物 可以在描述颅脑外伤后发生。