公开(公告)号：US5401492A

公开(公告)日：1995-03-28

申请号：US991893

申请日：1992-12-17

申请人： Kenneth E. Kellar ,  Piotr H. Karpinski ,  Elaine Liversidge ,  Wolfgang H. H. Gunther ,  Gregory L. McIntire ,  Barbara Van Orman

发明人： Kenneth E. Kellar ,  Piotr H. Karpinski ,  Elaine Liversidge ,  Wolfgang H. H. Gunther ,  Gregory L. McIntire ,  Barbara Van Orman

IPC分类号： A61K49/00 ,  A61K33/32 ,  A61K49/18 ,  A61N2/00 ,  C01G45/00 ,  A61B5/055 ,  A61K33/42

CPC分类号： A61K49/1821 ,  A61K33/32 ,  A61K49/1818 ,  Y10S514/836 ,  Y10T436/24

摘要： This invention is directed to a magnetic resonance imaging composition for imaging of an organ rich in mitochondria comprising particles of a substantially insoluble manganese compound. In a preferred embodiment, the organ rich in mitochondria is the liver. In a further preferred embodiment, the particles are substantially nonmagnetic. In another preferred embodiment, the particles have a particle size of less than about 10 microns.In a still further preferred embodiment, the insoluble manganese compound is a manganese salt. The manganese compound is preferably selected from the group consisting of manganese phosphate, manganese carbonate and manganese 8-hydroxy quinolate.In another preferred embodiment, the composition of the present invention further comprises a surfactant.The present invention is also directed to a method of diagnosis comprising administering to a mammal a contrast effective amount of particles of a substantially insoluble manganese compound suspended or dispersed in a physiologically tolerable carrier and generating an NMR image of said mammal.

摘要翻译： 本发明涉及一种磁共振成像组合物，用于对含有基本上不溶性锰化合物的颗粒的富含线粒体的器官进行成像。 在优选的实施方案中，富含线粒体的器官是肝脏。 在另一优选实施方案中，颗粒基本上是非磁性的。 在另一个优选的实施方案中，颗粒具有小于约10微米的粒度。 在另一优选实施方案中，不溶性锰化合物是锰盐。 锰化合物优选选自磷酸锰，碳酸锰和8-羟基喹啉锰。 在另一个优选的实施方案中，本发明的组合物还包含表面活性剂。 本发明还涉及一种诊断方法，包括向哺乳动物施用对比有效量的悬浮或分散在生理上可耐受载体中的基本上不溶性锰化合物的颗粒并产生所述哺乳动物的NMR图像。