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公开(公告)号:US20130039895A1
公开(公告)日:2013-02-14
申请号:US13652672
申请日:2012-10-16
Applicant: Jun Lu , Shangqin Guo , Benjamin Ebert , David Scadden , Todd Golub
Inventor: Jun Lu , Shangqin Guo , Benjamin Ebert , David Scadden , Todd Golub
IPC: A61K48/00 , A61K31/7088 , A61P7/06
CPC classification number: C12N15/113 , A61K31/7105 , C12N2310/111 , C12N2310/113 , C12N2310/141 , C12N2310/315 , C12N2310/321 , C12N2310/341 , C12N2310/346 , C12N2310/3515 , C12N2330/10 , C12N2310/3521
Abstract: The invention provides methods of treating certain blood related disorders, in particular, thrombocytopenia and anemia comprising increasing miR-150 expression or inhibiting miR-150 in progenitor cells respectively.
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公开(公告)号:US20090202493A1
公开(公告)日:2009-08-13
申请号:US12363016
申请日:2009-01-30
Applicant: Jun Lu , Shangqin Guo , Benjamin Ebert , David Scadden , Todd Golub
Inventor: Jun Lu , Shangqin Guo , Benjamin Ebert , David Scadden , Todd Golub
CPC classification number: C12N15/113 , A61K31/7105 , C12N2310/111 , C12N2310/113 , C12N2310/141 , C12N2310/315 , C12N2310/321 , C12N2310/341 , C12N2310/346 , C12N2310/3515 , C12N2330/10 , C12N2310/3521
Abstract: The invention provides methods of treating certain blood related disorders, in particular, thrombocytopenia and anemia comprising increasing miR-150 expression or inhibiting miR-150 in progenitor cells respectively.
Abstract translation: 本发明提供了治疗某些血液相关病症,特别是血小板减少症和贫血症的方法,其包括分别增加miR-150表达或在祖细胞中抑制miR-150。
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公开(公告)号:US09164094B2
公开(公告)日:2015-10-20
申请号:US13452344
申请日:2012-04-20
Applicant: W. Nicholas Haining , Benjamin Ebert , Bruce Walker
Inventor: W. Nicholas Haining , Benjamin Ebert , Bruce Walker
IPC: A61K31/7105 , C12Q1/70 , G01N33/569
CPC classification number: G01N33/56988 , G01N2333/16 , G01N2800/52 , G01N2800/56
Abstract: The invention relates to expression profiles of HIV-specific T-cells and their methods of use, including but not limited to treatment of HIV, increasing T-cell function and/or survival in HIV infected subjects, monitoring HIV disease progression and classifying HIV infected subjects as controllers or chronic progressors.
Abstract translation: 本发明涉及HIV特异性T细胞的表达谱及其使用方法,包括但不限于HIV的治疗,增加HIV感染受试者的T细胞功能和/或存活,监测HIV疾病进展和分类HIV感染 作为控制者或慢性进步者。
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公开(公告)号:US08530443B2
公开(公告)日:2013-09-10
申请号:US13652672
申请日:2012-10-16
Applicant: Jun Lu , Shangqin Guo , Benjamin Ebert , David Scadden , Todd Golub
Inventor: Jun Lu , Shangqin Guo , Benjamin Ebert , David Scadden , Todd Golub
CPC classification number: C12N15/113 , A61K31/7105 , C12N2310/111 , C12N2310/113 , C12N2310/141 , C12N2310/315 , C12N2310/321 , C12N2310/341 , C12N2310/346 , C12N2310/3515 , C12N2330/10 , C12N2310/3521
Abstract: The invention provides methods of treating certain blood related disorders, in particular, thrombocytopenia and anemia comprising increasing miR-150 expression or inhibiting miR-150 in progenitor cells respectively.
Abstract translation: 本发明提供了治疗某些血液相关病症,特别是血小板减少症和贫血症的方法,其包括分别增加miR-150表达或在祖细胞中抑制miR-150。
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公开(公告)号:US20130005792A1
公开(公告)日:2013-01-03
申请号:US13452344
申请日:2012-04-20
Applicant: W. N. Haining , Benjamin Ebert , Bruce Walker
Inventor: W. N. Haining , Benjamin Ebert , Bruce Walker
IPC: C12Q1/70 , G01N21/78 , C40B30/04 , A61P31/18 , C40B40/10 , A61K31/7105 , A61K31/713 , G01N21/64 , C40B40/06
CPC classification number: G01N33/56988 , G01N2333/16 , G01N2800/52 , G01N2800/56
Abstract: The invention relates to expression profiles of HIV-specific T-cells and their methods of use, including but not limited to treatment of HIV, increasing T-cell function and/or survival in HIV infected subjects, monitoring HIV disease progression and classifying HIV infected subjects as controllers or chronic progressors.
Abstract translation: 本发明涉及HIV特异性T细胞的表达谱及其使用方法,包括但不限于HIV的治疗,增加HIV感染受试者的T细胞功能和/或存活,监测HIV疾病进展和分类HIV感染 作为控制者或慢性进步者。
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