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公开(公告)号：US09809610B2
公开(公告)日：2017-11-07
申请号：US15397787
申请日：2017-01-04
IPC分类号： C07D403/12 , C07D213/74 , C07D413/04 , C07D413/14 , A61K31/675 , C07F9/6558
CPC分类号： C07F9/65583 , A61K31/675 , C07D213/74 , C07D403/12 , C07D413/04 , C07D413/14
摘要： The present invention provides a compound of Formula I: wherein X, Y, Z, R1 and R2 are as described herein, and salts thereof and therapeutic uses of these compounds for treatment of disorders associated with RAF kinase activity. The invention further provides pharmaceutical compositions comprising these compounds, and compositions comprising these compounds and a therapeutic co-agent.
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公开(公告)号：US09573969B2
公开(公告)日：2017-02-21
申请号：US14851249
申请日：2015-09-11
IPC分类号： C07D213/74 , C07D403/12 , C07D413/04 , C07D413/14 , C07F9/6558 , A61K31/675
CPC分类号： C07F9/65583 , A61K31/675 , C07D213/74 , C07D403/12 , C07D413/04 , C07D413/14
摘要： The present invention provides a compound of Formula I: wherein X, Y, Z, R1 and R2 are as described herein, and salts thereof and therapeutic uses of these compounds for treatment of disorders associated with RAF kinase activity. The invention further provides pharmaceutical compositions comprising these compounds, and compositions comprising these compounds and a therapeutic co-agent.
摘要翻译： 本发明提供式I的化合物：其中X，Y，Z，R 1和R 2如本文所述，其盐和这些化合物的治疗用途用于治疗与RAF激酶活性相关的病症。 本发明还提供包含这些化合物的药物组合物，以及包含这些化合物和治疗性助剂的组合物。
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公开(公告)号：US20160075727A1
公开(公告)日：2016-03-17
申请号：US14851249
申请日：2015-09-11
IPC分类号： C07F9/6558 , A61K31/675
CPC分类号： C07F9/65583 , A61K31/675 , C07D213/74 , C07D403/12 , C07D413/04 , C07D413/14
摘要： The present invention provides a compound of Formula I: wherein X, Y, Z, R1 and R2 are as described herein, and salts thereof and therapeutic uses of these compounds for treatment of disorders associated with RAF kinase activity. The invention further provides pharmaceutical compositions comprising these compounds, and compositions comprising these compounds and a therapeutic co-agent.
摘要翻译： 本发明提供式I的化合物：其中X，Y，Z，R 1和R 2如本文所述，其盐和这些化合物的治疗用途用于治疗与RAF激酶活性相关的病症。 本发明还提供包含这些化合物的药物组合物，以及包含这些化合物和治疗性助剂的组合物。
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公开(公告)号：US20170114083A1
公开(公告)日：2017-04-27
申请号：US15397787
申请日：2017-01-04
IPC分类号： C07F9/6558 , A61K31/675
CPC分类号： C07F9/65583 , A61K31/675 , C07D213/74 , C07D403/12 , C07D413/04 , C07D413/14
摘要： The present invention provides a compound of Formula I: wherein X, Y, Z, R1 and R2 are as described herein, and salts thereof and therapeutic uses of these compounds for treatment of disorders associated with RAF kinase activity. The invention further provides pharmaceutical compositions comprising these compounds, and compositions comprising these compounds and a therapeutic co-agent.
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