公开(公告)号：US07553505B2

公开(公告)日：2009-06-30

申请号：US11622468

申请日：2007-01-12

申请人： Ka Ming Ng ,  Qian Luo ,  Jingnan Zhang ,  Benny Harjo

发明人： Ka Ming Ng ,  Qian Luo ,  Jingnan Zhang ,  Benny Harjo

IPC分类号： A61K36/48

CPC分类号： A61K36/48 ,  A61K31/353

摘要： This invention relates to a novel soy isoflavone product with high purities and strong biological activities and the method of producing the same from natural soybeans, soybean materials (i.e. tofu dregs, soy molasses) and other plant sources. The method includes three steps consisting of extraction with an organic solvent, hydrolysis using an acid and crystallization using an antisolvent. The procedure is very simple and thus can be easily adapted for large-scale manufacturing. Moreover, the procedure is able to produce a high yield of total isoflavones at a lower cost. HPLC analysis and E-Screen bioassay reveal that the obtained product not only contains a high content of isoflavone aglycones by weight of dry matter but also exhibits strong estrogenic activity toward human cells. Therefore, the product should be efficacious for relieving menopausal symptoms and other estrogen-deficient diseases and can be used in health care supplements or as additives for foods, beverages or cosmetics.

摘要翻译： 本发明涉及一种具有高纯度和强生物活性的新型大豆异黄酮产品及其生产方法，包括天然大豆，大豆原料（即豆腐渣，大豆糖蜜）和其他植物来源。 该方法包括用有机溶剂萃取，使用酸水解和使用反溶剂进行结晶的三个步骤。 该程序非常简单，因此可以轻松适应大规模制造。 此外，该方法能够以更低的成本产生高产量的总异黄酮。 HPLC分析和E-Screen生物测定显示，所得产物不仅含有高含量的异黄酮糖苷配基，其重量为干物质，而且对人细胞表现出强烈的雌激素活性。 因此，该产品应有效减轻绝经症状和其他雌激素缺乏症，可用于保健品或食品，饮料或化妆品的添加剂。

公开(公告)号：US20070207224A1

公开(公告)日：2007-09-06

申请号：US11622468

申请日：2007-01-12

申请人： Ka Ming NG ,  Qian Luo ,  Jingnan Zhang ,  Benny Harjo

发明人： Ka Ming NG ,  Qian Luo ,  Jingnan Zhang ,  Benny Harjo

IPC分类号： A61K36/48 ,  A61K31/353

CPC分类号： A61K36/48 ,  A61K31/353

摘要： This invention relates to a novel soy isoflavone product with high purities and strong biological activities and the method of producing the same from natural soybeans, soybean materials (i.e. tofu dregs, soy molasses) and other plant sources. The method includes three steps consisting of extraction with an organic solvent, hydrolysis using an acid and crystallization using an antisolvent. The procedure is very simple and thus can be easily adapted for large-scale manufacturing. Moreover, the procedure is able to produce a high yield of total isoflavones at a lower cost. HPLC analysis and E-Screen bioassay reveal that the obtained product not only contains a high content of isoflavone aglycones by weight of dry matter but also exhibits strong estrogenic activity toward human cells. Therefore, the product should be efficacious for relieving menopausal symptoms and other estrogen-deficient diseases and can be used in health care supplements or as additives for foods, beverages or cosmetics.

摘要翻译： 本发明涉及一种具有高纯度和强生物活性的新型大豆异黄酮产品及其生产方法，包括天然大豆，大豆原料（即豆腐渣，大豆糖蜜）和其他植物来源。 该方法包括用有机溶剂萃取，使用酸水解和使用反溶剂进行结晶的三个步骤。 该程序非常简单，因此可以轻松适应大规模制造。 此外，该方法能够以更低的成本产生高产量的总异黄酮。 HPLC分析和E-Screen生物测定显示，所得产物不仅含有高含量的异黄酮糖苷配基，其重量为干物质，而且对人细胞表现出强烈的雌激素活性。 因此，该产品应有效减轻绝经症状和其他雌激素缺乏症，可用于保健品或食品，饮料或化妆品的添加剂。