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    Derivatives of N-phenylanthranilic acid and 2-benzimidazolone as potassium channel and/or neuron activity modulators
    2.
    发明授权
    Derivatives of N-phenylanthranilic acid and 2-benzimidazolone as potassium channel and/or neuron activity modulators 有权
    N-苯基邻氨基苯甲酸和2-苯并咪唑酮的衍生物作为钾通道和/或神经元活性调节剂

    公开(公告)号：US07632866B2

    公开(公告)日：2009-12-15

    申请号：US11110669

    申请日：2005-04-21

    申请人： Bernard Attali ,  Asher Peretz

    发明人： Bernard Attali ,  Asher Peretz

    IPC分类号： A61K31/16 ,  C07C233/00 ,  C07C239/00

    CPC分类号： A61K31/165 ,  A61K31/195 ,  A61K31/4184

    摘要： Compounds, compositions and methods are provided which are useful in the treatment of conditions such as central or peripheral nervous system disorders through the modulation of potassium ion flux through voltage-dependent potassium channels and/or depressing cortical and/or peripheral neuron activity are disclosed. Novel derivatives of N-phenylanthranilic acid are also disclosed.

    摘要翻译： 提供了通过通过电压依赖性钾通道调节钾离子通量和/或抑制皮质和/或周围神经元活性而可用于治疗诸如中枢或周围神经系统疾病的病症的化合物，组合物和方法。 还公开了N-苯基邻氨基苯甲酸的新型衍生物。

    N-phenyl anthranilic acid derivatives and uses thereof
    3.
    发明授权
    N-phenyl anthranilic acid derivatives and uses thereof 有权
    N-苯基邻氨基苯甲酸衍生物及其用途

    公开(公告)号：US08765815B2

    公开(公告)日：2014-07-01

    申请号：US12452353

    申请日：2008-09-18

    申请人： Bernard Attali ,  Asher Peretz

    发明人： Bernard Attali ,  Asher Peretz

    IPC分类号： A61K31/16 ,  C07D233/00 ,  C07D239/00

    CPC分类号： C07C237/20 ,  C07C229/42 ,  C07C229/58 ,  C07C233/54 ,  C07C237/32 ,  C07C291/02 ,  C07D207/40 ,  C07D213/80 ,  C07D303/16

    摘要： Compounds that can be used as openers or blockers of voltage-dependent potassium channels, and which are useful in the treatment of conditions such as central or peripheral nervous system disorders through the modulation of potassium ion flux through voltage-dependent potassium channels and/or depressing or enhancing cortical and/or peripheral neuron activity, compositions containing same and methods utilizing same are disclosed. Also disclosed are modulators of voltage-dependent potassium channels, which exhibit blocking of a TRPV1 channel, and hence are useful in the treatment of TRPV1-related conditions.

    摘要翻译： 可用作电压依赖性钾通道的开放剂或阻断剂的化合物，其可用于通过电压依赖性钾通道调节钾离子通量和/或抑制来治疗诸如中枢或周围神经系统疾病的病症 或增强皮质和/或周围神经元活性，含有其的组合物和利用其的方法被公开。 还公开了电压依赖性钾通道的调节剂，其表现出阻断TRPV1通道，因此可用于治疗TRPV1相关病症。

    Derivatives of N-phenylanthranilic acid and 2-benzimidazolone as potassium channel and/or neuron activity modulators
    4.
    发明申请
    Derivatives of N-phenylanthranilic acid and 2-benzimidazolone as potassium channel and/or neuron activity modulators 有权
    N-苯基邻氨基苯甲酸和2-苯并咪唑酮的衍生物作为钾通道和/或神经元活性调节剂

    公开(公告)号：US20050250833A1

    公开(公告)日：2005-11-10

    申请号：US11110669

    申请日：2005-04-21

    申请人： Bernard Attali ,  Asher Peretz

    发明人： Bernard Attali ,  Asher Peretz

    IPC分类号： A61K31/165 ,  A61K31/195 ,  A61K31/4184

    CPC分类号： A61K31/165 ,  A61K31/195 ,  A61K31/4184

    摘要： Compounds, compositions and methods are provided which are useful in the treatment of conditions such as central or peripheral nervous system disorders through the modulation of potassium ion flux through voltage-dependent potassium channels and/or depressing cortical and/or peripheral neuron activity are disclosed. Novel derivatives of N-phenylanthranilic acid are also disclosed.

    摘要翻译： 提供了通过通过电压依赖性钾通道调节钾离子通量和/或抑制皮质和/或周围神经元活性而可用于治疗诸如中枢或周围神经系统疾病的病症的化合物，组合物和方法。 还公开了N-苯基邻氨基苯甲酸的新型衍生物。

    Derivatives of N-phenylanthranilic acid and 2-benzimidazolone as potassium channel and/or neuron activity modulators
    5.
    发明授权
    Derivatives of N-phenylanthranilic acid and 2-benzimidazolone as potassium channel and/or neuron activity modulators 有权
    N-苯基邻氨基苯甲酸和2-苯并咪唑酮的衍生物作为钾通道和/或神经元活性调节剂

    公开(公告)号：US08278357B2

    公开(公告)日：2012-10-02

    申请号：US12591090

    申请日：2009-11-06

    申请人： Bernard Attali ,  Asher Peretz

    发明人： Bernard Attali ,  Asher Peretz

    IPC分类号： A61K31/16 ,  C07D233/00 ,  C07D239/00

    CPC分类号： A61K31/165 ,  A61K31/195 ,  A61K31/4184

    摘要： Compounds, compositions and methods are provided which are useful in the treatment of conditions such as central or peripheral nervous system disorders through the modulation of potassium ion flux through voltage-dependent potassium channels and/or depressing cortical and/or peripheral neuron activity are disclosed. Novel derivatives of N-phenylanthranilic acid are also disclosed.

    摘要翻译： 提供了通过通过电压依赖性钾通道调节钾离子通量和/或抑制皮质和/或周围神经元活性而可用于治疗诸如中枢或周围神经系统疾病的病症的化合物，组合物和方法。 还公开了N-苯基邻氨基苯甲酸的新型衍生物。

    Derivatives of N-phenylanthranilic acid and 2-benzimidazolone as potassium channel and/or neuron activity modulators
    8.
    发明申请
    Derivatives of N-phenylanthranilic acid and 2-benzimidazolone as potassium channel and/or neuron activity modulators 有权
    N-苯基邻氨基苯甲酸和2-苯并咪唑酮的衍生物作为钾通道和/或神经元活性调节剂

    公开(公告)号：US20100056591A1

    公开(公告)日：2010-03-04

    申请号：US12591090

    申请日：2009-11-06

    申请人： Bernard Attali ,  Asher Peretz

    发明人： Bernard Attali ,  Asher Peretz

    IPC分类号： A61K31/4166 ,  A61K31/19 ,  A61P25/00

    CPC分类号： A61K31/165 ,  A61K31/195 ,  A61K31/4184

    摘要： Compounds, compositions and methods are provided which are useful in the treatment of conditions such as central or peripheral nervous system disorders through the modulation of potassium ion flux through voltage-dependent potassium channels and/or depressing cortical and/or peripheral neuron activity are disclosed. Novel derivatives of N-phenylanthranilic acid are also disclosed.

    摘要翻译： 提供了通过通过电压依赖性钾通道调节钾离子通量和/或抑制皮质和/或周围神经元活性而可用于治疗诸如中枢或周围神经系统疾病的病症的化合物，组合物和方法。 还公开了N-苯基邻氨基苯甲酸的新型衍生物。