公开(公告)号：US5686266A

公开(公告)日：1997-11-11

申请号：US430033

申请日：1995-04-27

Applicant: Binhui Ni ,  Steven M. Paul

Inventor： Binhui Ni ,  Steven M. Paul

IPC: A61K38/00 ,  C07K14/47 ,  C12P21/06

CPC classification number: C07K14/47 ,  A61K38/00

Abstract: This invention describes a novel human brain Na.sup.+ -dependent inorganic phosphate cotransporter, designated the hBNPI protein. This invention also encompasses nucleic acids encoding this protein, or a fragment thereof, as well as methods employing this protein and the nucleic acid compounds.

Abstract translation: 本发明描述了一种命名为hBNPI蛋白的新型人脑Na +依赖性无机磷酸盐协同转运体。 本发明还包括编码该蛋白质或其片段的核酸，以及使用该蛋白质和核酸化合物的方法。

公开(公告)号：US5618918A

公开(公告)日：1997-04-08

申请号：US647481

申请日：1996-05-14

Applicant: Binhui Ni ,  Steven M. Paul

Inventor： Binhui Ni ,  Steven M. Paul

IPC: A61K38/00 ,  C07K14/47 ,  C07K14/435 ,  C07K14/705

CPC classification number: C07K14/47 ,  A61K38/00

Abstract: This invention describes a novel human brain Na.sup.+ -dependent inorganic phosphate cotransporter, designated the hBNPI protein. This invention also encompasses nucleic acids encoding this protein, or a fragment thereof, as well as methods employing this protein and the nucleic acid compounds.

Abstract translation: 本发明描述了一种命名为hBNPI蛋白的新型人脑Na +依赖性无机磷酸盐协同转运体。 本发明还包括编码该蛋白质或其片段的核酸，以及使用该蛋白质和核酸化合物的方法。

公开(公告)号：US5618677A

公开(公告)日：1997-04-08

申请号：US647484

申请日：1996-05-14

Applicant: Binhui Ni ,  Steven M. Paul

Inventor： Binhui Ni ,  Steven M. Paul

IPC: A61K38/00 ,  C07K14/47 ,  G01N33/53

CPC classification number: C07K14/47 ,  A61K38/00

Abstract: This invention describes a novel human brain Na.sup.+ -dependent inorganic phosphate cotransporter, designated the hBNPI protein. This invention also encompasses nucleic acids encoding this protein, or a fragment thereof, as well as methods employing this protein and the nucleic acid compounds.

Abstract translation: 本发明描述了一种命名为hBNPI蛋白的新型人脑Na +依赖性无机磷酸盐协同转运体。 本发明还包括编码该蛋白质或其片段的核酸，以及使用该蛋白质和核酸化合物的方法。

公开(公告)号：US5840509A

公开(公告)日：1998-11-24

申请号：US890542

申请日：1997-07-09

Applicant: Binhui Ni ,  Marc Paul ,  Xin Wu

Inventor： Binhui Ni ,  Marc Paul ,  Xin Wu

IPC: A61K38/00 ,  C12N9/64 ,  G01N33/573 ,  G01N33/68 ,  C12N9/48 ,  C12N9/14 ,  C12Q1/37

CPC classification number: C12N9/6475 ,  G01N33/573 ,  G01N33/6893 ,  G01N33/6896 ,  A61K38/00

Abstract: The present invention provides for a novel ICE related protease and nucleic acids coding same. The present invention also provides a method to isolate an ICE related protease and related DNA compounds encoding this protease. The present invention further comprises a method using said protease to screen for inhibitors of apoptosis. Additionally, the invention further comprises a method of using said inhibitors of apoptosis in the treatment in human patients with the acquired disease states of brain ischemia, stroke, Alzheimer's disease, amyotrophic lateral sclerosis (ALS), head trauma, or other neurodegenerative disorders.

Abstract translation: 本发明提供了一种新型的ICE相关蛋白酶及其编码的核酸。 本发明还提供了分离ICE相关蛋白酶和编码该蛋白酶的相关DNA化合物的方法。 本发明还包括使用所述蛋白酶筛选凋亡抑制剂的方法。 此外，本发明还包括在获得性脑缺血，中风，阿尔茨海默病，肌萎缩性侧索硬化（ALS），头部外伤或其它神经变性疾病的疾病状态的人类患者中治疗中使用所述凋亡抑制剂的方法。