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公开(公告)号:US20070184023A1
公开(公告)日:2007-08-09
申请号:US10577489
申请日:2004-10-28
IPC分类号: A61K39/385 , A61K38/21 , C07H21/04 , C07K14/475 , C12N1/15 , C12N1/21 , C12N15/63 , C12N15/74 , C12N15/79 , C12N5/04 , C12N5/06
CPC分类号: C07K14/52 , A61K38/00 , A61K39/00 , A61K47/61 , A61K47/6415 , A61K47/642 , Y02A50/412
摘要: The present invention provides for novel immunogenic variants of VEGF (vascular endothelial growth factor) which are useful in active specific immunotherapy against diseases that are characterized by overexpression of VEGF. The invention also relates to methods of treating such diseases (for instance cancer) as well as to various tools in molecular biology that assist in the provision of the immunogenic variants.
摘要翻译: 本发明提供VEGF(血管内皮生长因子)的新型免疫原性变体,其可用于针对以VEGF过表达为特征的疾病的活性特异性免疫疗法。 本发明还涉及治疗这些疾病(例如癌症)的方法以及有助于提供免疫原性变体的分子生物学中的各种工具。