公开(公告)号：US20170137521A1

公开(公告)日：2017-05-18

申请号：US15353886

申请日：2016-11-17

申请人： Juha Punnonen ,  Maribel Beaumont ,  Marie-Ange Buyse ,  Carlo Boutton ,  Bruno Dombrecht ,  Bjorn Victor

发明人： Juha Punnonen ,  Maribel Beaumont ,  Marie-Ange Buyse ,  Carlo Boutton ,  Bruno Dombrecht ,  Bjorn Victor

IPC分类号： C07K16/28 ,  A61K39/395 ,  C07K14/765

CPC分类号： C07K16/2818 ,  A61K39/3955 ,  A61K39/39558 ,  A61K2039/505 ,  A61K2039/54 ,  A61K2039/545 ,  C07K14/765 ,  C07K16/18 ,  C07K2317/22 ,  C07K2317/24 ,  C07K2317/31 ,  C07K2317/32 ,  C07K2317/33 ,  C07K2317/34 ,  C07K2317/35 ,  C07K2317/565 ,  C07K2317/569 ,  C07K2317/62 ,  C07K2317/76 ,  C07K2317/92 ,  C07K2319/31

摘要： The present invention provides molecules, such as ISVDs and Nanobodies, that bind to CTLA4 or human serum albumin. These molecules have been engineered so as to reduce the incidence of binding by pre-existing antibodies in the bodies of a subject administered such a molecule. Methods for increasing immune response, treating cancer and/or treating an infectious disease with such molecules are provided.

公开(公告)号：US20170137520A1

公开(公告)日：2017-05-18

申请号：US15353867

申请日：2016-11-17

申请人： Juha Punnonen ,  Edward Bowman ,  Maribel Beaumont ,  Marie-Ange Buyse ,  Carlo Boutton ,  Bruno Dombrecht ,  Bjorn Victor ,  David Vlerick

发明人： Juha Punnonen ,  Edward Bowman ,  Maribel Beaumont ,  Marie-Ange Buyse ,  Carlo Boutton ,  Bruno Dombrecht ,  Bjorn Victor ,  David Vlerick

IPC分类号： C07K16/28 ,  A61K39/395

CPC分类号： C07K16/2818 ,  A61K39/3955 ,  A61K39/39558 ,  A61K2039/505 ,  A61K2039/507 ,  A61K2039/54 ,  A61K2039/545 ,  C07K16/18 ,  C07K2317/22 ,  C07K2317/24 ,  C07K2317/31 ,  C07K2317/33 ,  C07K2317/34 ,  C07K2317/565 ,  C07K2317/569 ,  C07K2317/62 ,  C07K2317/76 ,  C07K2317/92 ,  Y02A50/403

摘要： The present invention provides multispecific molecules, e.g., comprising more than one ISVD or Nanobody, that bind to PD1 and CTLA4. These molecules have been engineered so as to reduce the incidence of binding by pre-existing antibodies in the bodies of a subject administered such a molecule. Methods for increasing immune response, treating cancer and/or treating an infectious disease with such molecules are provided.