公开(公告)号：US20170137520A1

公开(公告)日：2017-05-18

申请号：US15353867

申请日：2016-11-17

申请人： Juha Punnonen ,  Edward Bowman ,  Maribel Beaumont ,  Marie-Ange Buyse ,  Carlo Boutton ,  Bruno Dombrecht ,  Bjorn Victor ,  David Vlerick

发明人： Juha Punnonen ,  Edward Bowman ,  Maribel Beaumont ,  Marie-Ange Buyse ,  Carlo Boutton ,  Bruno Dombrecht ,  Bjorn Victor ,  David Vlerick

IPC分类号： C07K16/28 ,  A61K39/395

CPC分类号： C07K16/2818 ,  A61K39/3955 ,  A61K39/39558 ,  A61K2039/505 ,  A61K2039/507 ,  A61K2039/54 ,  A61K2039/545 ,  C07K16/18 ,  C07K2317/22 ,  C07K2317/24 ,  C07K2317/31 ,  C07K2317/33 ,  C07K2317/34 ,  C07K2317/565 ,  C07K2317/569 ,  C07K2317/62 ,  C07K2317/76 ,  C07K2317/92 ,  Y02A50/403

摘要： The present invention provides multispecific molecules, e.g., comprising more than one ISVD or Nanobody, that bind to PD1 and CTLA4. These molecules have been engineered so as to reduce the incidence of binding by pre-existing antibodies in the bodies of a subject administered such a molecule. Methods for increasing immune response, treating cancer and/or treating an infectious disease with such molecules are provided.

公开(公告)号：US20170137517A1

公开(公告)日：2017-05-18

申请号：US15353919

申请日：2016-11-17

申请人： Edward Bowman ,  Maribel Beaumont ,  Marie-Ange Buyse ,  Carlo Boutton ,  Bruno Dombrecht ,  David Vlerick

发明人： Edward Bowman ,  Maribel Beaumont ,  Marie-Ange Buyse ,  Carlo Boutton ,  Bruno Dombrecht ,  David Vlerick

IPC分类号： C07K16/28 ,  A61K45/06 ,  C07K16/46 ,  A61K39/395

CPC分类号： C07K16/2803 ,  A61K39/3955 ,  A61K45/06 ,  C07K16/18 ,  C07K16/2818 ,  C07K16/468 ,  C07K2317/22 ,  C07K2317/24 ,  C07K2317/31 ,  C07K2317/33 ,  C07K2317/34 ,  C07K2317/565 ,  C07K2317/569 ,  C07K2317/62 ,  C07K2317/76 ,  C07K2317/92

摘要： The present invention provides molecules, such as ISVDs and Nanobodies, that bind to PD1 and LAG3 and, optionally to human serum albumin. These molecules have been engineered so as to reduce the incidence of binding by pre-existing antibodies in the bodies of a subject administered such a molecule. Methods for increasing immune response, treating cancer and/or treating an infectious disease with such molecules are provided.

公开(公告)号：US4286437A

公开(公告)日：1981-09-01

申请号：US57350

申请日：1979-07-13

申请人： Fayez Abraham ,  Edward Bowman

发明人： Fayez Abraham ,  Edward Bowman

IPC分类号： F25B1/00 ,  F25B29/00 ,  F25B47/02 ,  F25B49/02 ,  F25D21/06 ,  F25B39/04 ,  F25B47/00

CPC分类号： F25B29/003 ,  F25B1/00 ,  F25B47/022 ,  F25B49/027 ,  F25B2400/075 ,  F25B2400/22 ,  Y10S62/17

摘要： A refrigeration system having an increased efficiency of operation and reduction in power consumption. By maintaining a low head pressure and subcooling the liquid refrigerant emitted from the remote condenser, the efficiency of operation of the compressor of the refrigeration system can be substantially increased. The particular type of refrigeration system of concern generally includes a compressor for compressing a gaseous refrigerant, a condenser for condensing the gaseous refrigerant and subcooling the liquid refrigerant, a receiver for receiving the liquid and a plurality of display cases having evaporators for evaporating the liquid refrigerant. The gaseous refrigerant passing through the condenser is first condensed into a liquid at a condensing temperature of approximately 10.degree. to 25.degree. F. above a preselected cooling temperature. The condensed liquid is then subcooled to the preselected cooling temperature which should be preferably either approximately 50.degree. F. or the temperature of the ambient atmosphere surrounding the condenser, whichever is higher.

摘要翻译： 具有提高的运行效率和降低功耗的制冷系统。 通过保持低压头并使从远程冷凝器排出的液体制冷剂过冷却，可以显着提高制冷系统的压缩机的运行效率。 关注的制冷系统的特定类型通常包括用于压缩气态制冷剂的压缩机，用于冷凝气态制冷剂并过冷液体制冷剂的冷凝器，用于接收液体的接收器和具有用于蒸发液体制冷剂的蒸发器的多个显示器 。 通过冷凝器的气态制冷剂首先在高于预选冷却温度的约10°至25°F的冷凝温度下冷凝成液体。 然后将冷凝的液体过冷至预选的冷却温度，该冷却温度应优选为约50°F或冷凝器周围环境气氛的温度（以较高者为准）。

公开(公告)号：US4373348A

公开(公告)日：1983-02-15

申请号：US226843

申请日：1981-01-21

申请人： Fayez Ibrahim ,  Edward Bowman

发明人： Fayez Ibrahim ,  Edward Bowman

IPC分类号： F25B1/00 ,  F25B29/00 ,  F25B47/02 ,  F25B49/02

CPC分类号： F25B47/022 ,  F25B1/00 ,  F25B29/003 ,  F25B49/027 ,  F25B2400/075 ,  F25B2400/22

摘要： A refrigeration system having an increasing efficiency of operation and reduction in power consumption. Low head pressure and subcooling the liquid refrigerant emitted from the remote condenser, the efficiency of operation of the compressor of the refrigeration system can be substantially increased. The particular type of refrigeration system of concern generally includes a compressor for compressing a gaseous refrigerant, a condenser for condensing the gaseous refrigerant and subcooling the liquid refrigerant, a receiver for receiving the liquid and a plurality of display cases having evaporators for evaporating the liquid refrigerant. The gaseous refrigerant passing through the condenser is first condensed into a liquid at a condensing temperature of approximately 10.degree. to 25.degree. F. above a preselected cooling temperature. The condensed liquid is then subcooled to the preselected cooling temperature which should be preferably either approximately 50.degree. F. or the temperature of the ambient atmosphere surrounding the condenser, whichever is higher.

摘要翻译： 一种具有增加的操作效率和降低功耗的制冷系统。 低压头并对从远程冷凝器排出的液体制冷剂进行过冷，能够显着提高制冷系统的压缩机的运转效率。 关注的制冷系统的特定类型通常包括用于压缩气态制冷剂的压缩机，用于冷凝气态制冷剂并过冷液体制冷剂的冷凝器，用于接收液体的接收器和具有用于蒸发液体制冷剂的蒸发器的多个显示器 。 通过冷凝器的气态制冷剂首先在高于预选冷却温度的约10°至25°F的冷凝温度下冷凝成液体。 然后将冷凝的液体过冷至预选的冷却温度，该冷却温度应优选为约50°F或冷凝器周围环境气氛的温度（以较高者为准）。

公开(公告)号：US4365983A

公开(公告)日：1982-12-28

申请号：US240465

申请日：1981-03-04

申请人： Fayez Abraham ,  Edward Bowman

发明人： Fayez Abraham ,  Edward Bowman

IPC分类号： F25B1/00 ,  F25B29/00 ,  F25B47/02 ,  F25B49/02 ,  F25B41/00

CPC分类号： F25B1/00 ,  F25B29/003 ,  F25B47/022 ,  F25B49/027 ,  F25B2400/075 ,  F25B2400/22

摘要： A refrigeration system having an increased efficiency of operation and reduction in power consumption. Low head pressure and subcooling the liquid refrigerant emitted from the remote condenser, the efficiency of operation of the compressor of the refrigeration system can be substantially increased. The particular type of refrigeration system of concern generally includes a compressor for compressing a gaseous refrigerant, a condenser for condensing the gaseous refrigerant and subcooling the liquid refrigerant, a receiver for receiving the liquid and a plurality of display cases having evaporators for evaporating the liquid refrigerant. The gaseous refrigerant passing through the condenser is first condensed into a liquid at a condensing temperature of approximately 10.degree. to 25.degree. F. above a preselected cooling temperature. The condensed liquid is then subcooled to the preselected cooling temperature which should be preferably either approximately 50.degree. F. or the temperature of the ambient atmosphere surrounding the condenser, whichever is higher.

摘要翻译： 具有提高的运行效率和降低功耗的制冷系统。 低压头并对从远程冷凝器排出的液体制冷剂进行过冷，能够显着提高制冷系统的压缩机的运转效率。 关注的制冷系统的特定类型通常包括用于压缩气态制冷剂的压缩机，用于冷凝气态制冷剂并过冷液体制冷剂的冷凝器，用于接收液体的接收器和具有用于蒸发液体制冷剂的蒸发器的多个显示器 。 通过冷凝器的气态制冷剂首先在高于预选冷却温度的约10°至25°F的冷凝温度下冷凝成液体。 然后将冷凝的液体过冷至预选的冷却温度，该冷却温度应优选为约50°F或冷凝器周围环境气氛的温度（以较高者为准）。