公开(公告)号：US20080146644A1

公开(公告)日：2008-06-19

申请号：US11815438

申请日：2006-02-02

申请人： Ernst Wulfert ,  Colin James Suckling ,  Abedawn Ibrahim Khalaf ,  Simon Paul Mackay ,  Blair Fraser Johnston

发明人： Ernst Wulfert ,  Colin James Suckling ,  Abedawn Ibrahim Khalaf ,  Simon Paul Mackay ,  Blair Fraser Johnston

IPC分类号： A61K31/403 ,  C07D209/96 ,  C07D209/70 ,  C07D209/58 ,  A61P9/10

CPC分类号： C07D491/10 ,  A61K31/403 ,  A61K31/404 ,  A61K31/407 ,  C07D209/88 ,  C07D495/04

摘要： Compounds of formula (I): [in which: X is a group of formula >CR1R2 or >SO2; Y is a group of formula >NH or >CR1R2; Z is a group of formula >C═O or >CH2 or a direct bond; R1 is hydrogen and R2 is hydrogen, carboxy or hydroxy; or R1 and R2 together represent an oxo group, a methylenedioxy group or a hydroxyimino group; R3 is hydrogen or lower alkyl; R4 represents two hydrogen atoms, or an oxo or hydroxyimino group; R5 is hydrogen, lower alkyl or halogen; R6 is hydrogen, lower alkoxy or carboxy; R7 and R8 are each hydrogen, lower alkyl or halogen; and pharmaceutically acceptable salts and esters thereof can be used for the treatment or prophylaxis of acute or chronic neurodegenerative diseases or conditions such as Alzheimer's Disease, Parkinson's Disease, Huntington's Chorea, Multiple Sclerosis or the sequelae to acute ischaemic events such as heart attack, stroke or head injury and for protection against ischaemic damage to tissues of peripheral organs.

摘要翻译： 式（I）的化合物：[其中：X为式>基团R 2或SO 2 SO 2的基团; Y是式> NH或> CR 1的基团 Z是式> C-O或> CH 2的基团或直接键; R 1是氢，R 2是氢，羧基或羟基; 或R 1和R 2一起代表氧代基，亚甲二氧基或羟基亚氨基; R 3是氢或低级烷基; R 4表示两个氢原子，或氧代或羟基亚氨基; R 5是氢，低级烷基或卤素; R 6是氢，低级烷氧基或羧基; R 7和R 8各自为氢，低级烷基或卤素; 及其药学上可接受的盐和酯可用于治疗或预防急性或慢性神经变性疾病或病症如阿尔茨海默病，帕金森病，亨廷顿氏舞蹈病，多发性硬化症或急性缺血事件的后遗症如心脏病发作，中风或 头部损伤和保护免受周围器官组织的缺血性损伤。

公开(公告)号：US20090259043A1

公开(公告)日：2009-10-15

申请号：US12427528

申请日：2009-04-21

申请人： Ernst Wulfert ,  Colin James Suckling ,  Abedawn Ibrahim Khalaf ,  Simon Paul Mackay ,  Blair Fraser Johnston

发明人： Ernst Wulfert ,  Colin James Suckling ,  Abedawn Ibrahim Khalaf ,  Simon Paul Mackay ,  Blair Fraser Johnston

IPC分类号： C07D471/04 ,  C07D209/56 ,  C07D495/04 ,  C07D209/54

CPC分类号： C07D491/10 ,  A61K31/403 ,  A61K31/404 ,  A61K31/407 ,  C07D209/88 ,  C07D495/04

摘要： Compounds of formula (I): [in which: X is a group of formula >CR1R2 or >SO2; Y is a group of formula >NH or >CR1R2; Z is a group of formula >C═O or >CH2 or a direct bond; R1 is hydrogen and R2 is hydrogen, carboxy or hydroxy; or R1 and R2 together represent an oxo group, a methylenedioxy group or a hydroxyimino group; R3 is hydrogen or lower alkyl; R4 represents two hydrogen atoms, or an oxo or hydroxyimino group; R5 is hydrogen, lower alkyl or halogen; R6 is hydrogen, lower alkoxy or carboxy; R7 and R8 are each hydrogen, lower alkyl or halogen; and pharmaceutically acceptable salts and esters thereof can be used for the treatment or prophylaxis of acute or chronic neurodegenerative diseases or conditions such as Alzheimer's Disease, Parkinson's Disease, Huntington's Chorea, Multiple Sclerosis or the sequelae to acute ischaemic events such as heart attack, stroke or head injury and for protection against ischaemic damage to tissues of peripheral organs.

摘要翻译： 式（I）化合物：[其中：X为式> CR1R2或> SO2的基团; Y是式> NH或> CR1R2的基团; Z是式> C-O或> CH2或直接键的基团; R1是氢，R2是氢，羧基或羟基; 或R 1和R 2一起表示氧代基，亚甲二氧基或羟基亚氨基; R3是氢或低级烷基; R4代表两个氢原子，或氧代或羟基亚氨基; R5是氢，低级烷基或卤素; R6是氢，低级烷氧基或羧基; R7和R8各自为氢，低级烷基或卤素; 及其药学上可接受的盐和酯可用于治疗或预防急性或慢性神经变性疾病或病症如阿尔茨海默病，帕金森病，亨廷顿氏舞蹈病，多发性硬化症或急性缺血事件的后遗症如心脏病发作，中风或 头部损伤和保护免受周围器官组织的缺血性损伤。