公开(公告)号：US3674840A

公开(公告)日：1972-07-04

申请号：US3674840D

申请日：1970-05-19

申请人： ARNE ELOF GRANDSTROM ,  CARLSSON ARVID EMIL ,  STIG AKE INGEMAR CARLSSON ,  HANS RUDOLF CORRODI ,  LARS EK ,  BO ROBERT LAMM ,  BENGT ARNE HJALMAR ABLAD

发明人： GRANDSTROM ARNE ELOF ,  CARLSSON PER ARVID EMIL ,  CARLSSON STIG AKE INGEMAR ,  CORRODI HANS RUDOLF ,  EK LARS ,  LAMM BO ROBERT ,  ABLAD BENGT ARNE HJALMAR

IPC分类号： A61K31/13 ,  A61K31/135 ,  A61P9/06 ,  A61P9/08 ,  C07C59/68 ,  C07C67/00 ,  C07C213/00 ,  C07C217/30 ,  C07D303/24 ,  C07C93/06

CPC分类号： A61K31/135 ,  C07C59/68 ,  C07D303/24 ,  Y02P20/55

摘要： Compounds of the formula:

WHERE Z is an oxaradical (a) R-O-(CH2)n-O-, (b) R-O-(CH2)m-O(CH2)n-O-; n is an integer equal to 2-3; m is an integer equal to 2-3 and R is an alkyl radical having one to five carbon atoms; and pharmaceutically acceptable, non-toxic, acid addition salts thereof. Illustrative are compounds where R is isopropyl or tbutyl and Z is CH3-O-CH2-CH2-O-, or CH3-O-CH2CH2-O-CH2CH2-O-. Also pharmaceutical compositions containing these compounds, and the use thereof in treating cardiovascular diseases.

摘要翻译： 下式的化合物：

公开(公告)号：US5674387A

公开(公告)日：1997-10-07

申请号：US470848

申请日：1995-06-06

申请人： William H. Pirkle ,  Christopher J. Welch ,  Bo Robert Lamm

发明人： William H. Pirkle ,  Christopher J. Welch ,  Bo Robert Lamm

IPC分类号： C07C51/487 ,  C07C275/30 ,  B01D15/08

CPC分类号： C07C51/487 ,  C07C275/30

摘要： The invention relates to a chiral selector useful in separating underivatized enantiomers of nonsteroidal anti-inflammatory agents, particularly naproxen and other arylacetic acid compounds, and relates to a process for achieving such separation utilizing the chiral selector, which is also useful in achieving the enantiomeric separation of amines, alcohol derivatives, epoxides and sulfoxides. The invention is also directed to an apparatus which comprises the chiral selectors.

摘要翻译： 本发明涉及可用于分离非甾体抗炎剂，特别是萘普生和其它芳基乙酸化合物的未衍生化对映异构体的手性选择剂，涉及使用手性选择剂实现这种分离的方法，其也可用于实现对映体分离 的胺，醇衍生物，环氧化物和亚砜。 本发明还涉及一种包括手性选择器的装置。