公开(公告)号：US09643966B2

公开(公告)日：2017-05-09

申请号：US15034129

申请日：2014-12-22

Applicant: Bohan Jin

Inventor： Bohan Jin

IPC: C07D471/04 ,  C07D471/14 ,  C07D491/22 ,  C07D491/147 ,  A61K31/4375 ,  A61K31/4353 ,  A61P35/00 ,  A61P29/00 ,  C07D491/00 ,  C07D471/00 ,  C07D471/12

CPC classification number: A61K31/437 ,  C07D471/04 ,  C07D471/14 ,  C07D491/147 ,  C07D491/22

Abstract: The present invention relates to novel compounds and pharmaceutical compositions thereof which may be useful in the treatment and/or prevention of various conditions. The present invention also provides methods of preparing such compounds and compositions, and methods of using the same.

公开(公告)号：US20160229855A1

公开(公告)日：2016-08-11

申请号：US15024681

申请日：2014-10-14

Applicant: Bohan Jin

Inventor： Bohan Jin

IPC: C07D471/16

CPC classification number: C07D471/16 ,  C07D471/14 ,  C07D471/22 ,  C07D487/14 ,  C07D487/22

Abstract: The present invention relates to novel compounds and pharmaceutical compositions thereof which may be useful in the treatment and/or prevention of various conditions. The present invention also provides methods of preparing such compounds and compositions, and methods of using the same.

Abstract translation: 本发明涉及可用于治疗和/或预防各种病症的新化合物及其药物组合物。 本发明还提供了制备这种化合物和组合物的方法及其使用方法。

公开(公告)号：US08268819B2

公开(公告)日：2012-09-18

申请号：US13429865

申请日：2012-03-26

Applicant: Bohan Jin ,  Nicholas Scorah ,  Qing Dong

Inventor： Bohan Jin ,  Nicholas Scorah ,  Qing Dong

IPC: A61K31/5383 ,  C07D498/14 ,  A61P35/00

CPC classification number: C07D498/14

Abstract: The present invention relates to intermediates of the formula wherein G1 is N; G2 is selected from the group consisting of C═O and CH2; X is a halogen; and the other groups are defined herein.

Abstract translation: 本发明涉及下式的中间体，其中G1是N; G2选自C = O和CH 2; X是卤素; 并且其他组在本文中定义。

公开(公告)号：US20120220575A1

公开(公告)日：2012-08-30

申请号：US13404958

申请日：2012-02-24

Applicant: Edcon Chang ,  Tony Gibson ,  Bohan Jin ,  Nicholas Scorah ,  Qing Dong

Inventor： Edcon Chang ,  Tony Gibson ,  Bohan Jin ,  Nicholas Scorah ,  Qing Dong

IPC: A61K31/5383 ,  A61P29/00 ,  A61P35/00 ,  A61P9/00 ,  A61P37/08 ,  A61P11/06 ,  A61P17/00 ,  A61P25/00 ,  A61P19/04 ,  A61P17/06 ,  A61P7/02 ,  A61P1/00 ,  A61P11/00 ,  A61P1/04 ,  A61P9/10 ,  C07D498/14

CPC classification number: C07D498/14 ,  A61K31/5383 ,  A61K45/06

Abstract: Disclosed are compounds of Formula 1, and pharmaceutically acceptable salts thereof, wherein Ar, R1, R2, R3, G1, G2, and m are defined in the specification. This disclosure also relates to materials and methods for preparing compounds of Formula 1, to pharmaceutical compositions which contain them, and to their use for treating inflammatory disorders, cardiovascular disease, cancer, and other conditions associated with PI3Kδ.

Abstract translation: 公开了式1的化合物及其药学上可接受的盐，其中Ar，R1，R2，R3，G1，G2和m在说明书中定义。 本公开还涉及用于制备式1化合物的材料和方法，含有它们的药物组合物及其用于治疗与PI3Kδ相关的炎性疾病，心血管疾病，癌症和其它病症的用途。

公开(公告)号：US20110178070A1

公开(公告)日：2011-07-21

申请号：US12996662

申请日：2009-06-23

Applicant: Xianchang Gong ,  Bohan Jin ,  Massaki Hirose ,  Feng Zhou ,  Qing Dong

Inventor： Xianchang Gong ,  Bohan Jin ,  Massaki Hirose ,  Feng Zhou ,  Qing Dong

IPC: A61K31/551 ,  C07D513/04 ,  A61K31/437 ,  A61P35/00 ,  C07D277/82 ,  A61K31/428 ,  C07D417/10 ,  A61K31/4439 ,  A61K31/497 ,  A61K31/519 ,  A61K31/496

CPC classification number: C07D513/04 ,  C07D519/00

Abstract: The invention relates to PI3K/mTOR inhibiting compounds consisting of the formula: wherein the variables are as defined herein. The invention also relates to pharmaceutical compositions, kits and articles of manufacture comprising such compounds; methods and intermediates useful for making the compounds; and methods of using said compounds.

Abstract translation: 本发明涉及由下式组成的PI3K / mTOR抑制化合物：其中变量如本文所定义。 本发明还涉及包含这些化合物的药物组合物，试剂盒和制品; 用于制备化合物的方法和中间体; 以及使用所述化合物的方法。

公开(公告)号：US20110021515A1

公开(公告)日：2011-01-27

申请号：US12841940

申请日：2010-07-22

Applicant: Qing DONG ,  Bohan Jin ,  Matthew Lardy ,  Feng Zhao

Inventor： Qing DONG ,  Bohan Jin ,  Matthew Lardy ,  Feng Zhao

IPC: A61K31/5377 ,  C07D491/048 ,  C07D498/08 ,  A61K31/5386 ,  A61P35/00 ,  A61P37/06

CPC classification number: C07D491/048 ,  C07D519/00

Abstract: The present invention provides mTOR inhibitors of the formula wherein the variables are as defined herein. Also provided are pharmaceutical compositions, kits and articles of manufacture comprising such compounds; methods of making the compounds and intermediates thereof; and methods of using the compounds.

Abstract translation: 本发明提供下式的mTOR抑制剂，其中变量如本文所定义。 还提供了包含这些化合物的药物组合物，试剂盒和制品; 制备化合物及其中间体的方法; 和使用该化合物的方法。

公开(公告)号：US20120178924A1

公开(公告)日：2012-07-12

申请号：US13429865

申请日：2012-03-26

Applicant: Bohan Jin ,  Nicholas Scorah ,  Qing Dong

Inventor： Bohan Jin ,  Nicholas Scorah ,  Qing Dong

IPC: C07D498/14

CPC classification number: C07D498/14

Abstract: The present invention relates to intermediates of the formula wherein G1 is N; G2 is selected from the group consisting of C═O and CH2; X is a halogen; and the other groups are defined herein.

Abstract translation: 本发明涉及下式的中间体，其中G1是N; G2选自C = O和CH 2; X是卤素; 并且其他组在本文中定义。

公开(公告)号：US08163755B2

公开(公告)日：2012-04-24

申请号：US12869452

申请日：2010-08-26

Applicant: Bohan Jin ,  Nicholas Scorah ,  Qing Dong

Inventor： Bohan Jin ,  Nicholas Scorah ,  Qing Dong

IPC: A61K31/497 ,  C07D237/36

CPC classification number: C07D498/14

Abstract: The present invention provides mTOR inhibitors of the formula wherein the variables are as defined herein. Also provided are pharmaceutical compositions, kits and articles of manufacture comprising such compounds; methods of making the compounds and intermediates thereof; and methods of using the compounds.

Abstract translation: 本发明提供下式的mTOR抑制剂，其中变量如本文所定义。 还提供了包含这些化合物的药物组合物，试剂盒和制品; 制备化合物及其中间体的方法; 和使用该化合物的方法。

公开(公告)号：US20110053921A1

公开(公告)日：2011-03-03

申请号：US12869452

申请日：2010-08-26

Applicant: Bohan Jin ,  Nicholas Scorah ,  Qing Dong

Inventor： Bohan Jin ,  Nicholas Scorah ,  Qing Dong

IPC: A61K31/5383 ,  C07D498/14 ,  A61P35/00

CPC classification number: C07D498/14

Abstract: The present invention provides mTOR inhibitors of the formula wherein the variables are as defined herein. Also provided are pharmaceutical compositions, kits and articles of manufacture comprising such compounds; methods of making the compounds and intermediates thereof; and methods of using the compounds.

Abstract translation: 本发明提供下式的mTOR抑制剂，其中变量如本文所定义。 还提供了包含这些化合物的药物组合物，试剂盒和制品; 制备化合物及其中间体的方法; 和使用该化合物的方法。

公开(公告)号：US08791107B2

公开(公告)日：2014-07-29

申请号：US13404958

申请日：2012-02-24

Applicant: Edcon Chang ,  Tony Gibson ,  Bohan Jin ,  Nicholas Scorah ,  Qing Dong

Inventor： Edcon Chang ,  Tony Gibson ,  Bohan Jin ,  Nicholas Scorah ,  Qing Dong

IPC: A61K31/5383 ,  C07D498/14

CPC classification number: C07D498/14 ,  A61K31/5383 ,  A61K45/06

Abstract: Disclosed are compounds of Formula 1, and pharmaceutically acceptable salts thereof, wherein Ar, R1, R2, R3, G1, G2, and m are defined in the specification. This disclosure also relates to materials and methods for preparing compounds of Formula 1, to pharmaceutical compositions which contain them, and to their use for treating inflammatory disorders, cardiovascular disease, cancer, and other conditions associated with PI3Kδ.

Abstract translation: 公开了式1的化合物及其药学上可接受的盐，其中Ar，R1，R2，R3，G1，G2和m在说明书中定义。 本公开还涉及用于制备式1化合物的材料和方法，含有它们的药物组合物及其用于治疗与PI3Kδ相关的炎性疾病，心血管疾病，癌症和其它病症的用途。