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115 条记录 (耗时 0.06 秒)

    MAPK/ERK kinase inhibitors
    6.
    发明授权
    MAPK/ERK kinase inhibitors 有权
    MAPK / ERK激酶抑制剂

    公开(公告)号：US08088783B2

    公开(公告)日：2012-01-03

    申请号：US13082259

    申请日：2011-04-07

    申请人： Qing Dong ,  Stephen W. Kaldor

    发明人： Qing Dong ,  Stephen W. Kaldor

    IPC分类号： A61K31/505 ,  C07D401/00

    CPC分类号： C07D239/545 ,  C07D239/557 ,  C07D401/12 ,  C07D403/06 ,  C07D405/12 ,  C07D413/06

    摘要： Compounds of the substituted 1,3-dialkyl-2,4-dioxo-6-(pyrimidinylamino)-1,2,3,4-tetrahydropyrimidine-5-hydroxamic acids, show below: wherein the variables are as defined herein, and pharmaceutical compositions thereof, are provided for use as inhibitors of with MEK kinase.”

    摘要翻译： 取代的1,3-二烷基-2,4-二氧代-6-（嘧啶基氨基）-1,2,3,4-四氢嘧啶-5-异羟肟酸的化合物如下所示：其中变量如本文所定义，药物 提供其组合物用作MEK激酶的抑制剂。

    MAPK/ERK kinase inhibitors
    7.
    发明授权
    MAPK/ERK kinase inhibitors 有权
    MAPK / ERK激酶抑制剂

    公开(公告)号：US08063066B2

    公开(公告)日：2011-11-22

    申请号：US12050139

    申请日：2008-03-17

    申请人： Qing Dong ,  Toufiko Kanounl ,  Michael B. Wallace

    发明人： Qing Dong ,  Toufiko Kanounl ,  Michael B. Wallace

    IPC分类号： C07D215/00

    CPC分类号： C07D215/56 ,  C07D215/38 ,  C07D401/12 ,  C07D471/04 ,  C07D491/052

    摘要： Compounds are provided for use with MEK that comprise: wherein the variables are as defined herein. Also provided are pharmaceutical compositions, kits and articles of manufacture comprising such compounds; methods and intermediates useful for making the compounds; and methods of using said compounds.

    摘要翻译： 提供了与MEK一起使用的化合物，其包含：其中变量如本文所定义。 还提供了包含这些化合物的药物组合物，试剂盒和制品; 用于制备化合物的方法和中间体; 以及使用所述化合物的方法。

    PRESSURE FLUSHING DEVICE
    10.
    发明申请
    PRESSURE FLUSHING DEVICE 失效
    压力冲洗装置

    公开(公告)号：US20100212078A1

    公开(公告)日：2010-08-26

    申请号：US12599958

    申请日：2008-07-17

    申请人： Xiao-Qing Dong

    发明人： Xiao-Qing Dong

    IPC分类号： E03D3/10 ,  E03D5/09

    CPC分类号： E03D3/10

    摘要： This invention is a toilet flushing system. It consists of a button controlled pressure flushing device, a sealed water tank, a flushing valve, major and minor flushing control valves, an air induce device and a one-way water valve. The characteristic of the system is that the button controlled pressure flushing device has a water-volume adjustable valve, a flushing valve with a sealed cavity which has a water injection pipe and a water release pipe. The inlet and the outlet of the water-volume adjustable valve are connected to the outlet of the one-way water valve and water injection pipe of the flushing valve respectively. The inlets of the major and minor flushing control valve are connected to the water release pipe of the flushing valve. The outlets of the major and minor control valves are linked to the main release outlet which has large diameter and high speed on-off action. Compare with the existing pressure-assistant flushing system, its structure is simple and at the same times, the amount of water used in the minor flushing can be controlled by adjusting the flow difference between water-volume adjustable valve and the minor control valve.

    摘要翻译： 本发明是一种马桶冲洗系统。 它包括按钮控制的冲压装置，密封水箱，冲洗阀，主要和次冲洗控制阀，空气诱导装置和单向水阀。 该系统的特点是按钮控制式冲压装置具有水量调节阀，带有密封腔的冲洗阀，具有注水管和排水管。 水量调节阀的入口和出口分别连接到冲洗阀的单向水阀和注水管的出口。 主冲程和次冲洗控制阀的入口连接到冲洗阀的排水管。 主控制阀和次控制阀的出口连接到具有大直径和高速开关动作的主释放出口。 与现有的压力辅助冲洗系统相比，其结构简单，同时可以通过调节水量调节阀和次控制阀之间的流量差来控制小冲洗中使用的水量。