公开(公告)号：US20060079560A1

公开(公告)日：2006-04-13

申请号：US11248461

申请日：2005-10-12

申请人： Natasa Milac ,  Anton Copar ,  Barbara Podobnik ,  Andreja Belcic ,  Alenka Kosak ,  Brina Ornik ,  Uros Urleb

发明人： Natasa Milac ,  Anton Copar ,  Barbara Podobnik ,  Andreja Belcic ,  Alenka Kosak ,  Brina Ornik ,  Uros Urleb

IPC分类号： A61K31/4439 ,  C07D403/02

CPC分类号： C07D401/12

摘要： A novel crystalline form of the substrate known under the chemical name 5-methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]sulfiny]-1H-benzimidazole, and having the generic name omeprazole, hereinafter referred to as omeprozole form C, is disclosed. Further, a process for the preparation of omeprazole form C, a pharmaceutical formulation containing omeprazole form C in admixture with pharmaceutically acceptable excipients and the use of omeprazole form C for treatment of gastrointestinal disorders are disclosed.

公开(公告)号：US07553856B2

公开(公告)日：2009-06-30

申请号：US11248461

申请日：2005-10-12

申请人： Natasa H Milac ,  Anton Copar ,  Barbara Podobnik ,  Andreja C Belcic ,  Alenka Kosak ,  Brina Ornik ,  Uros Urleb

发明人： Natasa H Milac ,  Anton Copar ,  Barbara Podobnik ,  Andreja C Belcic ,  Alenka Kosak ,  Brina Ornik ,  Uros Urleb

IPC分类号： A61K31/4439

CPC分类号： C07D401/12

摘要： A novel crystalline form of the substrate known under the chemical name 5-methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]sulfiny]-1H-benzimidazole, and having the generic name omeprazole, hereinafter referred to as omeprozole form C, is disclosed. Further, a process for the preparation of omeprazole form C, a pharmaceutical formulation containing omeprazole form C in admixture with pharmaceutically acceptable excipients and the use of omeprazole form C for treatment of gastrointestinal disorders are disclosed.

摘要翻译： 以化学名称为5-甲氧基-2 - [[（4-甲氧基-3,5-二甲基-2-吡啶基）甲基]亚磺酰基] -1H-苯并咪唑的新颖的底物结晶形式，具有通用名奥美拉唑 ，以下称为奥美曲唑C型。 此外，公开了制备奥美拉唑C型的方法，一种含有与药学上可接受的赋形剂混合的奥美拉唑C形式的药物制剂以及奥美拉唑C型用于治疗胃肠道疾病的用途。