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公开(公告)号：US07998690B2
公开(公告)日：2011-08-16
申请号：US12765351
申请日：2010-04-22
IPC分类号： G01N33/53
CPC分类号： G01N33/6893 , G01N2800/325
摘要： Disclosed herein are methods of detecting and/or prognosing congestive heart failure by detecting a proteolytic fragment of caspase-3 such as the p17 fragment or the p12 fragment. The congestive heart failure can be of any etiology, such as systolic or diastolic heart failure, ischemic or non-ischemic cardiomyopathy.
摘要翻译： 本文公开了通过检测诸如p17片段或p12片段的半胱天冬酶-3的蛋白水解片段来检测和/或预测充血性心力衰竭的方法。 充血性心力衰竭可以是任何病因，如收缩期或舒张期心力衰竭，缺血性或非缺血性心肌病。
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公开(公告)号：US20100203566A1
公开(公告)日：2010-08-12
申请号：US12765351
申请日：2010-04-22
IPC分类号： C12Q1/37
CPC分类号： G01N33/6893 , G01N2800/325
摘要： Disclosed herein are methods of detecting and/or prognosing congestive heart failure by detecting a proteolytic fragment of caspase-3 such as the p17 fragment or the p12 fragment. The congestive heart failure can be of any etiology, such as systolic or diastolic heart failure, ischemic or non-ischemic cardiomyopathy.
摘要翻译： 本文公开了通过检测诸如p17片段或p12片段的半胱天冬酶-3的蛋白水解片段来检测和/或预测充血性心力衰竭的方法。 充血性心力衰竭可以是任何病因，如收缩期或舒张期心力衰竭，缺血性或非缺血性心肌病。
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公开(公告)号：US20090226937A1
公开(公告)日：2009-09-10
申请号：US12400061
申请日：2009-03-09
IPC分类号： G01N33/573 , C12Q1/34
CPC分类号： G01N33/6893 , G01N2800/325
摘要： Disclosed herein are methods of detecting and/or prognosing congestive heart failure by detecting a proteolytic fragment of caspase-3 such as the p17 fragment or the p12 fragment. The congestive heart failure can be of any etiology, such as systolic or diastolic heart failure, ischemic or non-ischemic cardiomyopathy.
摘要翻译： 本文公开了通过检测诸如p17片段或p12片段的半胱天冬酶-3的蛋白水解片段来检测和/或预测充血性心力衰竭的方法。 充血性心力衰竭可以是任何病因，如收缩期或舒张期心力衰竭，缺血性或非缺血性心肌病。
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公开(公告)号：US20080312180A1
公开(公告)日：2008-12-18
申请号：US12054523
申请日：2008-03-25
IPC分类号： A61K31/7076 , A61K31/52 , A61K31/519 , A61K31/437 , A61P21/00
CPC分类号： A61K31/52 , A61K31/7076
摘要： Disclosed herein are compositions and methods for the treatment of skeletal muscle and/or the protection of skeletal muscle against injury. The adenosine A3 receptor has been identified as a new therapeutic target for the treatment of skeletal muscle. Adenosine A3 receptor agonists are used treat subjects with skeletal muscle ischemia and reperfusion (I/R) injuries, individuals with skeletal muscle disorders, and individuals suffering from skeletal muscle injury resulting from physical exertion.
摘要翻译： 本文公开了用于治疗骨骼肌和/或保护骨骼肌免受损伤的组合物和方法。 腺苷A3受体已经被鉴定为用于治疗骨骼肌的新的治疗靶标。 使用腺苷A3受体激动剂治疗患有骨骼肌缺血和再灌注（I / R）损伤的受试者，具有骨骼肌障碍的个体和患有由体力消耗引起的骨骼肌损伤的个体。
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公开(公告)号：US07867983B2
公开(公告)日：2011-01-11
申请号：US12054523
申请日：2008-03-25
CPC分类号： A61K31/52 , A61K31/7076
摘要： Disclosed herein are compositions and methods for the treatment of skeletal muscle and/or the protection of skeletal muscle against injury. The adenosine A3 receptor has been identified as a new therapeutic target for the treatment of skeletal muscle. Adenosine A3 receptor agonists are used treat subjects with skeletal muscle ischemia and reperfusion (I/R) injuries, individuals with skeletal muscle disorders, and individuals suffering from skeletal muscle injury resulting from physical exertion.
摘要翻译： 本文公开了用于治疗骨骼肌和/或保护骨骼肌免受损伤的组合物和方法。 腺苷A3受体已经被鉴定为用于治疗骨骼肌的新的治疗靶标。 使用腺苷A3受体激动剂治疗患有骨骼肌缺血和再灌注（I / R）损伤的受试者，具有骨骼肌障碍的个体和患有由体力消耗引起的骨骼肌损伤的个体。
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公开(公告)号：US07745150B2
公开(公告)日：2010-06-29
申请号：US12400061
申请日：2009-03-09
IPC分类号： G01N33/53
CPC分类号： G01N33/6893 , G01N2800/325
摘要： Disclosed herein are methods of detecting and/or prognosing congestive heart failure by detecting a proteolytic fragment of caspase-3 such as the p17 fragment or the p12 fragment. The congestive heart failure can be of any etiology, such as systolic or diastolic heart failure, ischemic or non-ischemic cardiomyopathy.
摘要翻译： 本文公开了通过检测诸如p17片段或p12片段的半胱天冬酶-3的蛋白水解片段来检测和/或预测充血性心力衰竭的方法。 充血性心力衰竭可以是任何病因，如收缩期或舒张期心力衰竭，缺血性或非缺血性心肌病。
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