公开(公告)号：US20080312180A1

公开(公告)日：2008-12-18

申请号：US12054523

申请日：2008-03-25

申请人： Bruce Tsan-Tang Liang ,  Edward John Zambraski

发明人： Bruce Tsan-Tang Liang ,  Edward John Zambraski

IPC分类号： A61K31/7076 ,  A61K31/52 ,  A61K31/519 ,  A61K31/437 ,  A61P21/00

CPC分类号： A61K31/52 ,  A61K31/7076

摘要： Disclosed herein are compositions and methods for the treatment of skeletal muscle and/or the protection of skeletal muscle against injury. The adenosine A3 receptor has been identified as a new therapeutic target for the treatment of skeletal muscle. Adenosine A3 receptor agonists are used treat subjects with skeletal muscle ischemia and reperfusion (I/R) injuries, individuals with skeletal muscle disorders, and individuals suffering from skeletal muscle injury resulting from physical exertion.

摘要翻译： 本文公开了用于治疗骨骼肌和/或保护骨骼肌免受损伤的组合物和方法。 腺苷A3受体已经被鉴定为用于治疗骨骼肌的新的治疗靶标。 使用腺苷A3受体激动剂治疗患有骨骼肌缺血和再灌注（I / R）损伤的受试者，具有骨骼肌障碍的个体和患有由体力消耗引起的骨骼肌损伤的个体。

公开(公告)号：US07867983B2

公开(公告)日：2011-01-11

申请号：US12054523

申请日：2008-03-25

申请人： Bruce Tsan-Tang Liang ,  Edward John Zambraski

发明人： Bruce Tsan-Tang Liang ,  Edward John Zambraski

IPC分类号： A01N43/04 ,  A61K31/70

CPC分类号： A61K31/52 ,  A61K31/7076

摘要： Disclosed herein are compositions and methods for the treatment of skeletal muscle and/or the protection of skeletal muscle against injury. The adenosine A3 receptor has been identified as a new therapeutic target for the treatment of skeletal muscle. Adenosine A3 receptor agonists are used treat subjects with skeletal muscle ischemia and reperfusion (I/R) injuries, individuals with skeletal muscle disorders, and individuals suffering from skeletal muscle injury resulting from physical exertion.

摘要翻译： 本文公开了用于治疗骨骼肌和/或保护骨骼肌免受损伤的组合物和方法。 腺苷A3受体已经被鉴定为用于治疗骨骼肌的新的治疗靶标。 使用腺苷A3受体激动剂治疗患有骨骼肌缺血和再灌注（I / R）损伤的受试者，具有骨骼肌障碍的个体和患有由体力消耗引起的骨骼肌损伤的个体。