公开(公告)号：US10596246B2

公开(公告)日：2020-03-24

申请号：US14368957

申请日：2011-12-29

申请人： Beatrice Maria Arico ,  Brunella Brunelli ,  Maurizio Comanducci ,  Mariagrazia Pizza ,  Silvana Savino ,  Maria Scarselli

发明人： Beatrice Maria Arico ,  Brunella Brunelli ,  Maurizio Comanducci ,  Mariagrazia Pizza ,  Silvana Savino ,  Maria Scarselli

IPC分类号： A61K39/095 ,  A61K47/64 ,  A61K39/09 ,  A61K39/00 ,  A61K39/39

摘要： The M01573 sequence of meningococcal fHbp offers poor coverage in a vaccine. The invention addresses this poor coverage in two ways. In a first aspect, a fHbp-based vaccine includes two family I fHbp sequences, one which is more closely related to MC58 than to M01573, and vice versa. In a second aspect, a multi-family fHbp-based vaccine uses a family I fHbp sequence which is more closely related to MC58 than to M01573, in combination with a family III fHbp sequence. The compositions are adjuvanted with an aluminium phosphate adjuvant.

公开(公告)号：US20150209419A1

公开(公告)日：2015-07-30

申请号：US14368957

申请日：2011-12-29

申请人： Beatrice Maria Arico ,  Brunella Brunelli ,  Maurizio Comanducci ,  Mariagrazia Pizza ,  Silvana Savino ,  Maria Scarselli

发明人： Beatrice Maria Arico ,  Brunella Brunelli ,  Maurizio Comanducci ,  Mariagrazia Pizza ,  Silvana Savino ,  Maria Scarselli

IPC分类号： A61K39/095 ,  A61K39/09 ,  A61K47/48 ,  A61K39/39

CPC分类号： A61K39/095 ,  A61K39/092 ,  A61K39/39 ,  A61K47/646 ,  A61K2039/55505

摘要： The M01573 sequence of meningococcal fHbp offers poor coverage in a vaccine. The invention addresses this poor coverage in two ways. In a first aspect, a fHbp-based vaccine includes two family I fHbp sequences, one which is more closely related to MC58 than to M01573, and vice versa. In a second aspect, a multi-family fHbp-based vaccine uses a family I fHbp sequence which is more closely related to MC58 than to M01573, in combination with a family III fHbp sequence. The compositions are adjuvanted with an aluminium phosphate adjuvant.

摘要翻译： 脑膜炎球菌fHbp的M01573序列在疫苗中的覆盖范围较差。 本发明以两种方式解决了这种差的覆盖面。 在第一方面，基于fHbp的疫苗包括两个家族I fHbp序列，一个与MC58比M01573更密切相关的序列，反之亦然。 在第二方面，多家fHbp基疫苗使用与MC58比M01573更紧密相关的家族I fHbp序列，与III族fHbp序列组合。 用磷酸铝佐剂佐剂组合物。

公开(公告)号：US10478483B2

公开(公告)日：2019-11-19

申请号：US13806743

申请日：2011-06-24

申请人： Maria Aricò ,  Brunella Brunelli ,  Maurizio Comanducci ,  Mariagrazia Pizza ,  Silvana Savino ,  Maria Scarselli

发明人： Maria Aricò ,  Brunella Brunelli ,  Maurizio Comanducci ,  Mariagrazia Pizza ,  Silvana Savino ,  Maria Scarselli

IPC分类号： A61K39/095 ,  A61K39/385 ,  A61K39/39 ,  A61K39/00

摘要： The M01573 sequence of meningococcal fHbp offers poor coverage in a vaccine. The invention addresses this poor coverage in two ways. In a first aspect, a fHbp-based vaccine includes two family I fHbp sequences, one which is more closely related to MC58 than to M01573, and vice versa. In a second aspect, a multi-family fHbp-based vaccine uses a family I fHbp sequence which is more closely related to MC58 than to M01573, in combination with a family III fHbp sequence.

公开(公告)号：US20130189295A1

公开(公告)日：2013-07-25

申请号：US13806743

申请日：2011-06-24

申请人： Maria Aricò ,  Brunella Brunelli ,  Maurizio Comanducci ,  Mariagrazia Pizza ,  Silvana Savino ,  Maria Scarselli

发明人： Maria Aricò ,  Brunella Brunelli ,  Maurizio Comanducci ,  Mariagrazia Pizza ,  Silvana Savino ,  Maria Scarselli

IPC分类号： A61K39/095 ,  A61K39/385 ,  A61K39/39

CPC分类号： A61K39/095 ,  A61K39/385 ,  A61K39/39 ,  A61K2039/55505 ,  A61K2039/70

摘要： The M01573 sequence of meningococcal fHbp offers poor coverage in a vaccine. The invention addresses this poor coverage in two ways. In a first aspect, a fHbp-based vaccine includes two family I fHbp sequences, one which is more closely related to MC58 than to M01573, and vice versa. In a second aspect, a multi-family fHbp-based vaccine uses a family I fHbp sequence which is more closely related to MC58 than to M01573, in combination with a family III fHbp sequence.

摘要翻译： 脑膜炎球菌fHbp的M01573序列在疫苗中的覆盖范围较差。 本发明以两种方式解决了这种差的覆盖面。 在第一方面，基于fHbp的疫苗包括两个家族I fHbp序列，一个与MC58比M01573更密切相关的序列，反之亦然。 在第二方面，多家fHbp基疫苗使用与MC58比M01573更紧密相关的家族I fHbp序列，与III族fHbp序列组合。