公开(公告)号：US20050250120A1

公开(公告)日：2005-11-10

申请号：US10980194

申请日：2004-11-04

Applicant: Stewart Cole ,  Stephen Gordon ,  Buchrieser-Brosch Roland ,  Alain Billault ,  Thierry Garnier

Inventor： Stewart Cole ,  Stephen Gordon ,  Buchrieser-Brosch Roland ,  Alain Billault ,  Thierry Garnier

IPC: A61P37/00 ,  C07K14/35 ,  C12N15/31 ,  C12Q1/68 ,  C07H21/04

CPC classification number: C12Q1/689 ,  C07K14/35

Abstract: The subject of the present invention is the identification of nucleotide and peptide sequences which make it possible in particular to distinguish, in diagnostic terms, an immunization resulting from a BCG vaccination from an M. tuberculosis infection. The sequences in question are specific either to M. bovis BCG/M. bovis, or to M. tuberculosis. The subject of the present invention is also a method for detecting the sequences in question, a method for detecting antibodies generated by the products of expression of these sequences and the kits for carrying out these methods. Finally, the subject of the present invention is novel vaccines.

Abstract translation: 本发明的主题是核苷酸和肽序列的鉴定，这使得特别可以在诊断方面区分由结核分枝杆菌感染引起的BCG接种引起的免疫。 所述序列对于牛分枝杆菌BCG / M是特异性的。 牛，或结核分枝杆菌。 本发明的主题还是用于检测所述序列的方法，检测由这些序列的表达产物产生的抗体的方法和用于实施这些方法的试剂盒。 最后，本发明的主题是新型疫苗。