公开(公告)号：US20110027375A1

公开(公告)日：2011-02-03

申请号：US12738191

申请日：2008-10-14

申请人： Olivier Tillement ,  Stéphane Roux ,  Pascal Perriat ,  Géraldine Leduc ,  Céline Mandon ,  Brice Mutelet ,  Christophe Alric ,  Claire Billotey ,  Marc Janier ,  Cédric Louis

发明人： Olivier Tillement ,  Stéphane Roux ,  Pascal Perriat ,  Géraldine Leduc ,  Céline Mandon ,  Brice Mutelet ,  Christophe Alric ,  Claire Billotey ,  Marc Janier ,  Cédric Louis

IPC分类号： A61K9/14 ,  A61K33/24 ,  A61P35/00

CPC分类号： A61K41/0038 ,  A61K9/0019

摘要： The invention relates to the use of nanoparticles with dimensions comprised between 1 and 50 nm, at least one portion of which consists of at least one oxide and/or one oxohydroxide of at least one lanthanide, said nanoparticles: either consisting of at least one oxide and/or one oxohydroxide of at least one lanthanide, or in the form of nanoparticles comprising a core consisting of at least one oxide and/or one oxohydroxide of at least one lanthanide, and a coating consisting of polysiloxane, with possibly organic molecules grafted at the surface or comprised inside it, as a radio-sensitizing agent in the making of an injectable composition intended to improve the efficiency of the treatment of a tumor by X or gamma irradiations. It also relates to nanoparticles particularly suitable for the use above, consisting of a core consisting of at least one oxide and/or one oxohydroxide of at least one lanthanide and of a coating in polysiloxane comprising 1 to 5 silicon atoms per lanthanide and at least 10% of the silicon atoms of which are bound to hydrophilic organic molecules with molar masses of less than 450 g/mol.

摘要翻译： 本发明涉及使用尺寸为1至50nm的纳米颗粒，其至少一部分由至少一种镧系元素的至少一种氧化物和/或一种氧代氢氧化物组成，所述纳米颗粒由至少一种氧化物 或至少一种镧系元素的一种氧代氢氧化物，或纳米颗粒的形式，其包含由至少一种镧系元素的至少一种氧化物和/或一种氧代氢氧化物构成的核心，以及由聚硅氧烷组成的涂层，可能的有机分子被接枝在 表面或其内部，作为用于通过X或γ照射提高肿瘤治疗效率的可注射组合物的放射性增感剂。 它还涉及特别适合于上述用途的纳米颗粒，其由至少一种镧系元素的至少一种氧化物和/或一种氧代氢氧化物和每镧系元素含有1至5个硅原子的聚硅氧烷中的涂层和至少10个 其硅原子的％与摩尔质量小于450g / mol的亲水性有机分子结合。