公开(公告)号：US20110027375A1

公开(公告)日：2011-02-03

申请号：US12738191

申请日：2008-10-14

申请人： Olivier Tillement ,  Stéphane Roux ,  Pascal Perriat ,  Géraldine Leduc ,  Céline Mandon ,  Brice Mutelet ,  Christophe Alric ,  Claire Billotey ,  Marc Janier ,  Cédric Louis

发明人： Olivier Tillement ,  Stéphane Roux ,  Pascal Perriat ,  Géraldine Leduc ,  Céline Mandon ,  Brice Mutelet ,  Christophe Alric ,  Claire Billotey ,  Marc Janier ,  Cédric Louis

IPC分类号： A61K9/14 ,  A61K33/24 ,  A61P35/00

CPC分类号： A61K41/0038 ,  A61K9/0019

摘要： The invention relates to the use of nanoparticles with dimensions comprised between 1 and 50 nm, at least one portion of which consists of at least one oxide and/or one oxohydroxide of at least one lanthanide, said nanoparticles: either consisting of at least one oxide and/or one oxohydroxide of at least one lanthanide, or in the form of nanoparticles comprising a core consisting of at least one oxide and/or one oxohydroxide of at least one lanthanide, and a coating consisting of polysiloxane, with possibly organic molecules grafted at the surface or comprised inside it, as a radio-sensitizing agent in the making of an injectable composition intended to improve the efficiency of the treatment of a tumor by X or gamma irradiations. It also relates to nanoparticles particularly suitable for the use above, consisting of a core consisting of at least one oxide and/or one oxohydroxide of at least one lanthanide and of a coating in polysiloxane comprising 1 to 5 silicon atoms per lanthanide and at least 10% of the silicon atoms of which are bound to hydrophilic organic molecules with molar masses of less than 450 g/mol.

摘要翻译： 本发明涉及使用尺寸为1至50nm的纳米颗粒，其至少一部分由至少一种镧系元素的至少一种氧化物和/或一种氧代氢氧化物组成，所述纳米颗粒由至少一种氧化物 或至少一种镧系元素的一种氧代氢氧化物，或纳米颗粒的形式，其包含由至少一种镧系元素的至少一种氧化物和/或一种氧代氢氧化物构成的核心，以及由聚硅氧烷组成的涂层，可能的有机分子被接枝在 表面或其内部，作为用于通过X或γ照射提高肿瘤治疗效率的可注射组合物的放射性增感剂。 它还涉及特别适合于上述用途的纳米颗粒，其由至少一种镧系元素的至少一种氧化物和/或一种氧代氢氧化物和每镧系元素含有1至5个硅原子的聚硅氧烷中的涂层和至少10个 其硅原子的％与摩尔质量小于450g / mol的亲水性有机分子结合。

公开(公告)号：US08357545B2

公开(公告)日：2013-01-22

申请号：US10591465

申请日：2005-03-02

申请人： Pascal Perriat ,  Cédric Louis ,  Christophe Marquette ,  Rana Bazzi ,  Stéphane Roux ,  Olivier Tillement ,  Gilles Ledoux

发明人： Pascal Perriat ,  Cédric Louis ,  Christophe Marquette ,  Rana Bazzi ,  Stéphane Roux ,  Olivier Tillement ,  Gilles Ledoux

IPC分类号： G01N33/553

CPC分类号： G01N33/54346 ,  A61K41/009 ,  A61K49/0002 ,  A61K49/0093 ,  A61K49/1848 ,  A61K49/1857 ,  B82Y5/00 ,  B82Y30/00 ,  C01F17/0043 ,  C01P2002/52 ,  C01P2004/64 ,  G01N33/54353

摘要： The invention concerns hybrid nanoparticles containing: a nanosphere, of mean diameter included in the range from 2 to 9 nm, of which at least 90% by weight consists of Ln2O3 where Ln represents a rare earth, optionally doped with a rare earth or an actinide, or a mixture of rare earths, or a rare earth and actinide mixture, in which at least 50% of the metal ions are rare earth ions, a coating around the nanosphere chiefly consisting of functionalized polysiloxane, having a mean thickness included in the range from 0.5 to 10 nm, preferably greater than 2 nm and no more than 10 nm, and at least one biological ligand grafted by covalent bonding to the polysiloxane coating and their method of preparation.

摘要翻译： 本发明涉及包含纳米球的混合纳米颗粒，其平均直径包括在2至9nm的范围内，其中至少90重量％由Ln 2 O 3组成，其中Ln表示稀土，任选地掺杂有稀土或锕系元素 ，或稀土或稀土和锕系混合物的混合物，其中至少50％的金属离子是稀土离子，主要由官能化聚硅氧烷组成的纳米球周围的涂层，其平均厚度包括在该范围内 0.5至10nm，优选大于2nm且不超过10nm，以及至少一种通过与聚硅氧烷涂层共价键接枝的生物配体及其制备方法。

公开(公告)号：US09260957B2

公开(公告)日：2016-02-16

申请号：US13518827

申请日：2010-12-22

申请人： Annie Commarieu ,  Fabrice Aubertin ,  Nicolas Crowther ,  Cédric Louis ,  Pascal Perriat ,  Matteo Martini ,  Olivier Tillement

发明人： Annie Commarieu ,  Fabrice Aubertin ,  Nicolas Crowther ,  Cédric Louis ,  Pascal Perriat ,  Matteo Martini ,  Olivier Tillement

IPC分类号： G01N21/64 ,  E21B47/00 ,  C09K8/03 ,  C09K8/58 ,  E21B47/10 ,  C09K11/59 ,  B82Y15/00

CPC分类号： E21B47/00 ,  B82Y15/00 ,  C09K8/03 ,  C09K8/58 ,  C09K11/06 ,  C09K11/592 ,  E21B47/1015 ,  G01N21/64 ,  Y10S977/773 ,  Y10S977/902

摘要： The present invention relates to the development of tracer fluids, more generally, that of aqueous liquids, intended to be injected under pressure in an oil reservoir, for example from an injection well up to a production well.The object of the invention is to propose a new method of study of a solid medium, i.e. an oil reservoir, by diffusion of a liquid (i.e. injection waters) containing tracers, through said solid medium, which is simple to implement and economical and which remedies the drawbacks of the known tracers for injection waters of oil reservoirs.This method essentially consisting of injecting, in this solid medium, an injection liquid comprising a nanoparticle-based tracer having average dimensions comprised between 20 and 200 nm, detectable by means of one or several S signals at dilutions of less than or equal to 10−7, adapted to form a stable colloidal suspension in a saline medium, at least a portion of which is constituted of a core and a coating provided with an adjustable hydrophilic-lipophilic balance (HLB) and comprising at least one organic and/or organosilicon component; recovering the liquid having diffused; and analyzing this liquid having diffused to measure the quantity of tracer by detection of the signal or signals S.

摘要翻译： 本发明涉及示踪流体的开发，更一般地说，旨在在储油器中例如从注入井到生产井的压力下注入含水液体。 本发明的目的是提出一种通过所述固体介质通过扩散含有示踪剂的液体（即注射水）的固体介质，即储油器的研究的新方法，所述固体介质易于实施和经济，并且其中 弥补了油藏注射水已知示踪剂的缺点。 该方法基本上包括在该固体培养基中注入含有平均尺寸在20和200nm之间的纳米颗粒型示踪剂的注射液，其可以通过少于或等于10- 7，适于在盐水介质中形成稳定的胶体悬浮液，其至少一部分由芯和具有可调亲水亲油平衡（HLB）的涂层构成，并且包含至少一种有机和/或有机硅组分 ; 回收扩散的液体; 并且通过检测信号或信号S来分析扩散的液体以测量示踪剂的量。

公开(公告)号：US20130084643A1

公开(公告)日：2013-04-04

申请号：US13518827

申请日：2010-12-22

申请人： Annie Commarieu ,  Fabrice Aubertin ,  Nicolas Crowther ,  Cédric Louis ,  Pascal Perriat ,  Matteo Martini ,  Olivier Tillement

发明人： Annie Commarieu ,  Fabrice Aubertin ,  Nicolas Crowther ,  Cédric Louis ,  Pascal Perriat ,  Matteo Martini ,  Olivier Tillement

IPC分类号： E21B47/00 ,  G01N21/64 ,  C09K11/59

CPC分类号： E21B47/00 ,  B82Y15/00 ,  C09K8/03 ,  C09K8/58 ,  C09K11/06 ,  C09K11/592 ,  E21B47/1015 ,  G01N21/64 ,  Y10S977/773 ,  Y10S977/902

摘要： The present invention relates to the development of tracer fluids, more generally, that of aqueous liquids, intended to be injected under pressure in an oil reservoir, for example from an injection well up to a production well.The object of the invention is to propose a new method of study of a solid medium, i.e. an oil reservoir, by diffusion of a liquid (i.e. injection waters) containing tracers, through said solid medium, which is simple to implement and economical and which remedies the drawbacks of the known tracers for injection waters of oil reservoirs.This method essentially consisting of injecting, in this solid medium, an injection liquid comprising a nanoparticle-based tracer having average dimensions comprised between 20 and 200 nm, detectable by means of one or several S signals at dilutions of less than or equal to 10−7, adapted to form a stable colloidal suspension in a saline medium, at least a portion of which is constituted of a core and a coating provided with an adjustable hydrophilic-lipophilic balance (HLB) and comprising at least one organic and/or organosilicon component; recovering the liquid having diffused; and analyzing this liquid having diffused to measure the quantity of tracer by detection of the signal or signals S.

摘要翻译： 本发明涉及示踪流体的开发，更一般地说，旨在在储油器中例如从注入井到生产井的压力下注入含水液体。 本发明的目的是提出一种通过所述固体介质通过扩散含有示踪剂的液体（即注射水）的固体介质，即储油器的研究的新方法，所述固体介质易于实施和经济，并且其中 弥补了油藏注射水已知示踪剂的缺点。 该方法基本上包括在该固体培养基中注入含有平均尺寸在20和200nm之间的纳米颗粒型示踪剂的注射液，其可以通过少于或等于10- 7，适于在盐水介质中形成稳定的胶体悬浮液，其至少一部分由芯和具有可调亲水亲油平衡（HLB）的涂层构成，并且包含至少一种有机和/或有机硅组分 ; 回收扩散的液体; 并且通过检测信号或信号S来分析扩散的液体来测量示踪剂的量。