公开(公告)号：US20130231358A1

公开(公告)日：2013-09-05

申请号：US13884632

申请日：2011-11-10

申请人： Ian M. Bell ,  Mark E. Fraley ,  Steven N. Gallicchio ,  Anthony Ginnetti ,  Helen J. Mitchell ,  Daniel V. Paone ,  Donnette D. Staas ,  Cheng Wang ,  Blair C. Zartman ,  Heather E. Stevenson

发明人： Ian M. Bell ,  Mark E. Fraley ,  Steven N. Gallicchio ,  Anthony Ginnetti ,  Helen J. Mitchell ,  Daniel V. Paone ,  Donnette D. Staas ,  Cheng Wang ,  Blair C. Zartman ,  Heather E. Stevenson

IPC分类号： C07D471/04 ,  C07D487/04

CPC分类号： C07D471/04 ,  A61K31/506 ,  C07D487/04

摘要： The present invention is directed to piperidinone carboxamide indane derivatives which are antagonists of CGRP receptors and useful in the treatment or prevention of diseases in which the CGRP is involved, such as migraine. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CGRP is involved.

摘要翻译： 本发明涉及作为CGRP受体的拮抗剂的哌啶酮羧酰胺二氢化茚衍生物，其可用于治疗或预防涉及CGRP的疾病，例如偏头痛。 本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在预防或治疗涉及CGRP的疾病中的用途。

公开(公告)号：US20070111982A1

公开(公告)日：2007-05-17

申请号：US10546889

申请日：2004-03-10

申请人： Ian Bell ,  Steven Gallicchio ,  Craig Stump ,  C. Zartman

发明人： Ian Bell ,  Steven Gallicchio ,  Craig Stump ,  C. Zartman

IPC分类号： A61K31/553 ,  A61K31/4747 ,  A61K31/4188 ,  C07D413/02

CPC分类号： C07D233/78 ,  C07D235/02 ,  C07D401/12 ,  C07D403/12 ,  C07D413/12 ,  C07D471/10 ,  C07D513/04

摘要： The present invention is directed to compounds that are antagonists of CGRP receptors and that are useful in the treatment or prevention of diseases in which the CGRP is involved, such as headache, migraine and cluster headache. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CGRP is involved.

摘要翻译： 本发明涉及作为CGRP受体的拮抗剂的化合物，其可用于治疗或预防涉及CGRP的疾病，例如头痛，偏头痛和丛集性头痛。 本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在预防或治疗涉及CGRP的疾病中的用途。

公开(公告)号：US20060211712A1

公开(公告)日：2006-09-21

申请号：US10549338

申请日：2004-03-10

申请人： Ian Bell ,  Steven Gallicchio ,  Cory Theberge ,  Xu-Fang Zhang ,  Craig Stump ,  C. Zartman

发明人： Ian Bell ,  Steven Gallicchio ,  Cory Theberge ,  Xu-Fang Zhang ,  Craig Stump ,  C. Zartman

IPC分类号： A61K31/522 ,  A61K31/52 ,  A61K31/4747 ,  A61K31/427 ,  A61K31/421 ,  A61K31/4164

CPC分类号： C07D401/14 ,  C07D233/76 ,  C07D235/02 ,  C07D235/26 ,  C07D403/12 ,  C07D403/14 ,  C07D405/14 ,  C07D409/14 ,  C07D413/12 ,  C07D417/12 ,  C07D417/14 ,  C07D471/04 ,  C07D471/10

摘要： The present invention is directed to compounds of the formula: that are antagonists of CGRP receptors and that are useful in the treatment or prevention of diseases in which the CGRP is involved, such as headache, migraine and cluster headache. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CGRP is involved.

摘要翻译： 本发明涉及下式的化合物：其是CGRP受体的拮抗剂，其可用于治疗或预防涉及CGRP的疾病，例如头痛，偏头痛和丛集性头痛。 本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在预防或治疗涉及CGRP的疾病中的用途。

公开(公告)号：US08883807B2

公开(公告)日：2014-11-11

申请号：US13884632

申请日：2011-11-10

申请人： Ian M. Bell ,  Mark E. Fraley ,  Steven N. Gallicchio ,  Anthony Ginnetti ,  Helen J. Mitchell ,  Daniel V. Paone ,  Donnette D. Staas ,  Cheng Wang ,  Blair C. Zartman ,  Heather E. Stevenson

发明人： Ian M. Bell ,  Mark E. Fraley ,  Steven N. Gallicchio ,  Anthony Ginnetti ,  Helen J. Mitchell ,  Daniel V. Paone ,  Donnette D. Staas ,  Cheng Wang ,  Blair C. Zartman ,  Heather E. Stevenson

IPC分类号： A01N43/90 ,  A61K31/519 ,  A01N43/42 ,  A61K31/44 ,  C07D487/00 ,  C07D471/02 ,  C07D491/02 ,  C07D498/02 ,  C07D513/02 ,  C07D515/02 ,  A61K31/506 ,  C07D471/04 ,  C07D487/04

CPC分类号： C07D471/04 ,  A61K31/506 ,  C07D487/04

摘要： The present invention is directed to piperidinone carboxamide indane derivatives which are antagonists of CGRP receptors and useful in the treatment or prevention of diseases in which the CGRP is involved, such as migraine. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CGRP is involved.

摘要翻译： 本发明涉及作为CGRP受体的拮抗剂的哌啶酮羧酰胺二氢化茚衍生物，其可用于治疗或预防涉及CGRP的疾病，例如偏头痛。 本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在预防或治疗涉及CGRP的疾病中的用途。

公开(公告)号：US20060173046A1

公开(公告)日：2006-08-03

申请号：US10564706

申请日：2004-07-09

申请人： Ian Bell ,  Steven Gallicchio ,  C Zartman

发明人： Ian Bell ,  Steven Gallicchio ,  C Zartman

IPC分类号： A61K31/4439 ,  A61K31/4415 ,  C07D403/02

CPC分类号： C07D417/04 ,  C07D471/04

摘要： The present invention is directed to compounds of Formula I: I (where variables R1, R2, R3 and R4 are as defined herein) useful as antagonists of CGRP receptors and useful in the treatment or prevention of diseases in which CGRP is involved, such as headache, migraine and cluster headache. The invention is also directed to the use of such compounds as ligands of AM receptors for the treatment or prevention of diseases in which AM is involved, such as cancer. The invention is further directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CGRP and/or AM are involved.

摘要翻译： 本发明涉及式I化合物：其中变量R 1，R 2，R 3和R 4 可用作CGRP受体的拮抗剂，可用于治疗或预防涉及CGRP的疾病，例如头痛，偏头痛和丛集性头痛。 本发明还涉及这样的化合物作为AM受体的配体用于治疗或预防涉及AM的疾病如癌症的用途。 本发明进一步涉及包含这些化合物的药物组合物以及这些化合物和组合物在预防或治疗涉及CGRP和/或AM的疾病中的用途。