公开(公告)号：US20230242582A1

公开(公告)日：2023-08-03

申请号：US17918930

申请日：2021-04-12

申请人： CAMP THERAPEUTICS INC.

发明人： Jae-Hoon YU ,  Soon-sil HYUN ,  Jane CHO ,  Dong-Woo KIM

IPC分类号： C07K7/06 ,  A61K47/42 ,  A61K9/51

CPC分类号： C07K7/06 ,  A61K47/42 ,  A61K9/5169

摘要： The present disclosure relates to a novel amphipathic, alpha-helical cell-penetrating peptide and uses thereof. The cell-penetrating peptide of the present disclosure has a nanoparticle self-association characteristic and penetrates into eukaryotic cells at a nanomolar concentration, which allows the peptide to be advantageously used for delivery, into cells, of a drug or the like that is difficult to penetrate into the cells.

公开(公告)号：US20230181678A1

公开(公告)日：2023-06-15

申请号：US17917283

申请日：2021-04-05

申请人： CAMP THERAPEUTICS INC.

发明人： Soon-Sil HYUN ,  Yoon-Hwa CHOI ,  Seol-AH CHOO ,  Tae-Woo PARK ,  Jae-Hoon Yu

IPC分类号： A61K38/10 ,  A61K45/06 ,  A61P31/04

CPC分类号： A61K38/10 ,  A61K45/06 ,  A61P31/04

摘要： A novel antibacterial peptide or peptide analog and a therapeutic use thereof for bacterial infections are disclosed. Specifically, the peptide or peptide analog has a structure in which an amphipathic, alpha-helical peptide composed of hydrophobic amino acids and hydrophilic amino acids is kinked, with a fatty acid bound to the N-terminus thereof. The peptide or peptide analogs have a therapeutic use for bacterial infections, especially, infections caused by Gram-negative bacteria.