公开(公告)号：US20090298846A1

公开(公告)日：2009-12-03

申请号：US12421193

申请日：2009-04-09

Applicant: CHERNG-CHYI TZENG ,  YEH-LONG CHEN ,  JING-JER LIN ,  CHIH-MING LU

Inventor： CHERNG-CHYI TZENG ,  YEH-LONG CHEN ,  JING-JER LIN ,  CHIH-MING LU

IPC: A61K31/496 ,  C07D401/14 ,  C12N5/00 ,  C07D471/02 ,  A61K31/437 ,  A61P35/00

CPC classification number: C07D471/04

Abstract: Indolo[3,2-c]quinoline compounds of formula (I) shown below. Each variable in this formula is defined herein. These compounds can be used to inhibit both growth of cancer cells and activity of telomerase.

Abstract translation: 吲哚并[3,2-c]喹啉化合物。 此公式中的每个变量均在此定义。 这些化合物可用于抑制癌细胞的生长和端粒酶的活性。

公开(公告)号：US20100286163A1

公开(公告)日：2010-11-11

申请号：US12551315

申请日：2009-08-31

Applicant: Cherng-Chyi Tzeng ,  Yeh-Long Chen ,  Jing-Jer Lin ,  Chih-Ming Lu

Inventor： Cherng-Chyi Tzeng ,  Yeh-Long Chen ,  Jing-Jer Lin ,  Chih-Ming Lu

IPC: A61K31/496 ,  C07D471/04 ,  C12N5/02 ,  A61P35/00 ,  A61P35/04 ,  A61K31/4745

CPC classification number: C07D471/04

Abstract: Disclosed herein are indolo[3,2-c]quinoline compounds of formula (I): or a pharmaceutically acceptable salt thereof, wherein R and m are given the definitions as set forth in the Specification and Claims. These compounds can be used to inhibit both growth of cancer cells and activity of telomerase.

Abstract translation: 本文公开了式（I）的吲哚并[3,2-c]喹啉化合物：或其药学上可接受的盐，其中R和m被给出在说明书和权利要求中阐述的定义。 这些化合物可用于抑制癌细胞的生长和端粒酶的活性。

公开(公告)号：US07763633B2

公开(公告)日：2010-07-27

申请号：US12421193

申请日：2009-04-09

Applicant: Cherng-Chyi Tzeng ,  Yeh-Long Chen ,  Jing-Jer Lin ,  Chih-Ming Lu

Inventor： Cherng-Chyi Tzeng ,  Yeh-Long Chen ,  Jing-Jer Lin ,  Chih-Ming Lu

IPC: A61K31/4745 ,  C07D471/06

CPC classification number: C07D471/04

Abstract: Indolo[3,2-c]quinoline compounds of formula (I) shown below. Each variable in this formula is defined herein. These compounds can be used to inhibit both growth of cancer cells and activity of telomerase.

Abstract translation: 吲哚并[3,2-c]喹啉化合物。 此公式中的每个变量均在此定义。 这些化合物可用于抑制癌细胞的生长和端粒酶的活性。

公开(公告)号：US20060102766A1

公开(公告)日：2006-05-18

申请号：US10986359

申请日：2004-11-12

Applicant: Wen-Han Chang ,  Chih-Ming Lu

Inventor： Wen-Han Chang ,  Chih-Ming Lu

IPC: B65H75/48

CPC classification number: B65H75/4434 ,  H02G11/02

Abstract: A positioning shaft of a dual direction cable reel is disclosed. The cable reel comprises an upper cover, a pad, a reeling disc, a coiled cable, a spring, and a lower cover, characterized in that the reeling disc and a positioning element mounted at the inner edge of the lower cover form an engaging and disengaging mechanism, wherein the positioning element includes a positioning shaft and a positioning plate and the positioning plate covers the top portion of the positioning shaft and is secured with a peg and the positioning plate has a pivot hole at the center thereof for the pivot mounting of the positioning shaft, and the front end of the positioning plate exposed from the shaft body of the positioning shaft is provided with a sliding protruded section corresponding to the railing slot at the bottom section of the reeling disc, and the bottom section is provided with an operation railing slot for the sliding protruded section to rotate along the reeling slot so as to provide an alternating engaging and a disengaging action.

Abstract translation: 公开了双向电缆卷轴的定位轴。 电缆卷轴包括上盖，垫，卷盘，卷绕电缆，弹簧和下盖，其特征在于，卷盘和安装在下盖的内边缘处的定位元件形成接合和 脱离机构，其中定位元件包括定位轴和定位板，并且定位板覆盖定位轴的顶部并且用钉固定，并且定位板在其中心具有用于枢转安装的枢轴孔 定位轴和从定位轴的轴体暴露的定位板的前端设置有与卷取盘的底部处的栏杆槽对应的滑动突出部，并且底部设置有 操作栏杆槽，用于滑动突出部分沿着卷轴槽旋转，以便提供交替的接合和分离动作。

公开(公告)号：US08273760B2

公开(公告)日：2012-09-25

申请号：US12551315

申请日：2009-08-31

Applicant: Cherng-Chyi Tzeng ,  Yeh-Long Chen ,  Jing-Jer Lin ,  Chih-Ming Lu

Inventor： Cherng-Chyi Tzeng ,  Yeh-Long Chen ,  Jing-Jer Lin ,  Chih-Ming Lu

IPC: A61K31/4745 ,  A61K31/496 ,  C07D471/06 ,  C07D403/06

CPC classification number: C07D471/04

Abstract: Disclosed herein are indolo[3,2-c]quinoline compounds of formula (I): or a pharmaceutically acceptable salt thereof,wherein R and m are given the definitions as set forth in the Specification and Claims.These compounds can be used to inhibit both growth of cancer cells and activity of telomerase.

Abstract translation: 本文公开了式（I）的吲哚并[3,2-c]喹啉化合物：或其药学上可接受的盐，其中R和m被给出在说明书和权利要求中阐述的定义。 这些化合物可用于抑制癌细胞的生长和端粒酶的活性。

公开(公告)号：US07222812B2

公开(公告)日：2007-05-29

申请号：US10986359

申请日：2004-11-12

Applicant: Wen-Han Chang ,  Chih-Ming Lu

Inventor： Wen-Han Chang ,  Chih-Ming Lu

IPC: B65H75/48

CPC classification number: B65H75/4434 ,  H02G11/02

Abstract: A positioning shaft of a dual direction cable reel is disclosed. The cable reel comprises an upper cover, a pad, a reeling disc, a coiled cable, a spring, and a lower cover, characterized in that the reeling disc and a positioning element mounted at the inner edge of the lower cover form an engaging and disengaging mechanism, wherein the positioning element includes a positioning shaft and a positioning plate and the positioning plate covers the top portion of the positioning shaft and is secured with a peg and the positioning plate has a pivot hole at the center thereof for the pivot mounting of the positioning shaft, and the front end of the positioning plate exposed from the shaft body of the positioning shaft is provided with a sliding protruded section corresponding to the railing slot at the bottom section of the reeling disc, and the bottom section is provided with an operation railing slot for the sliding protruded section to rotate along the reeling slot so as to provide an alternating engaging and a disengaging action.

Abstract translation: 公开了双向电缆卷轴的定位轴。 电缆卷轴包括上盖，垫，卷盘，卷绕电缆，弹簧和下盖，其特征在于，卷盘和安装在下盖的内边缘处的定位元件形成接合和 脱离机构，其中定位元件包括定位轴和定位板，并且定位板覆盖定位轴的顶部并且用钉固定，并且定位板在其中心具有用于枢转安装的枢轴孔 定位轴和从定位轴的轴体暴露的定位板的前端设置有与卷取盘的底部处的栏杆槽对应的滑动突出部，并且底部设置有 操作栏杆槽，用于滑动突出部分沿着卷轴槽旋转，以便提供交替的接合和分离动作。