Polypeptides for the treatment or prevention of cancer and uses thereof
    2.
    发明授权
    Polypeptides for the treatment or prevention of cancer and uses thereof 有权
    用于治疗或预防癌症的多肽及其用途

    公开(公告)号:US09328141B2

    公开(公告)日:2016-05-03

    申请号:US13639488

    申请日:2010-09-29

    摘要: Disclosed herein are polypeptides or their derivatives and their application. The polypeptides and their derivatives can treat or prevent cancer. The polypeptides of the invention have significant lethality to the cancer cells when used alone. When its clinical commonly used chemotherapy drugs such as cisplatin in combination, it can significantly increase the sensitivity of chemotherapeutic agents on cancer cells, to enhance its lethality of cancer cells, to reduce the dosage. The peptides can kill a variety of cancer cells, but without apparent toxicity enhancing effect on normal cells. The prepared peptides of the present invention can be chemically synthesized, high-purity, low molecular weight, specificity, non-immunogenic, safe and reliable.

    摘要翻译: 本文公开的是多肽或其衍生物及其应用。 多肽及其衍生物可以治疗或预防癌症。 当单独使用时,本发明的多肽对癌细胞具有显着的致死性。 当其临床常用化疗药物如顺铂联合使用时,可显着增加化疗药对癌细胞的敏感性,增强其对癌细胞的致死性,降低剂量。 肽可以杀死各种癌细胞,但对正常细胞没有明显的毒性增强作用。 本发明制备的肽可以化学合成,高纯度,低分子量,特异性,非免疫原性,安全可靠。

    Polypeptides for the Treatment or Prevention of Cancer and uses Thereof
    3.
    发明申请
    Polypeptides for the Treatment or Prevention of Cancer and uses Thereof 审中-公开
    用于治疗或预防癌症的多肽及其用途

    公开(公告)号:US20130149372A1

    公开(公告)日:2013-06-13

    申请号:US13639488

    申请日:2010-09-29

    IPC分类号: C07K7/08 C07K5/00

    摘要: Disclosed herein are polypeptides or their derivatives and their application. The polypeptides and their derivatives can treat or prevent cancer. The polypeptides of the invention have significant lethality to the cancer cells when used alone. When its clinical commonly used chemotherapy drugs such as cisplatin in combination, it can significantly increase the sensitivity of chemotherapeutic agents on cancer cells, to enhance its lethality of cancer cells, to reduce the dosage. The peptides can kill a variety of cancer cells, but without apparent toxicity enhancing effect on normal cells. The prepared peptides of the present invention can be chemically synthesized, high-purity, low molecular weight, specificity, non-immunogenic, safe and reliable.

    摘要翻译: 本文公开的是多肽或其衍生物及其应用。 多肽及其衍生物可以治疗或预防癌症。 当单独使用时,本发明的多肽对癌细胞具有显着的致死性。 当其临床常用化疗药物如顺铂联合使用时,可显着增加化疗药对癌细胞的敏感性,增强其对癌细胞的致死性,降低剂量。 肽可以杀死各种癌细胞,但对正常细胞没有明显的毒性增强作用。 本发明制备的肽可以化学合成,高纯度,低分子量,特异性,非免疫原性,安全可靠。